Journal: PLoS ONE

Article Title: Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain

doi: 10.1371/journal.pone.0190841

Figure Lengend Snippet: DE microRNAs common to all 3 brain regions.

Article Snippet: All microRNA microarray data files are available from the National Center for Biotechnology Information Gene Expression Omnibus (NCBI GEO, https://www.ncbi.nlm.nih.gov/geo/ ), accession number GSE90608.

Techniques:

Journal: PLoS ONE

Article Title: Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain

doi: 10.1371/journal.pone.0190841

Figure Lengend Snippet: 0h DE microRNA targets dysregulated at multiple time points in each brain region.

Article Snippet: All microRNA microarray data files are available from the National Center for Biotechnology Information Gene Expression Omnibus (NCBI GEO, https://www.ncbi.nlm.nih.gov/geo/ ), accession number GSE90608.

Techniques:

Journal: PLoS ONE

Article Title: Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain

doi: 10.1371/journal.pone.0190841

Figure Lengend Snippet: Profiles are based on hierarchical clustering of centered and scaled expression log ratios of microRNAs DE in at least one time point. Average expression is plotted in red, and each individual microRNA is plotted in gray. Blue text indicates the total number of microRNAs in each cluster.

Article Snippet: All microRNA microarray data files are available from the National Center for Biotechnology Information Gene Expression Omnibus (NCBI GEO, https://www.ncbi.nlm.nih.gov/geo/ ), accession number GSE90608.

Techniques: Expressing

Journal: PLoS ONE

Article Title: Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain

doi: 10.1371/journal.pone.0190841

Figure Lengend Snippet: Profiles are based on hierarchical clustering of centered and scaled expression log ratios of microRNAs DE in at least one time point. Average expression is plotted in red, and each individual microRNA is plotted in gray. Blue text indicates the total number of microRNAs in each cluster.

Article Snippet: All microRNA microarray data files are available from the National Center for Biotechnology Information Gene Expression Omnibus (NCBI GEO, https://www.ncbi.nlm.nih.gov/geo/ ), accession number GSE90608.

Techniques: Expressing

Journal: PLoS ONE

Article Title: Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain

doi: 10.1371/journal.pone.0190841

Figure Lengend Snippet: Profiles are based on hierarchical clustering of centered and scaled expression log ratios of microRNAs DE in at least one time point. Average expression is plotted in red, and each individual microRNA is plotted in gray. Blue text indicates the total number of microRNAs in each cluster.

Article Snippet: All microRNA microarray data files are available from the National Center for Biotechnology Information Gene Expression Omnibus (NCBI GEO, https://www.ncbi.nlm.nih.gov/geo/ ), accession number GSE90608.

Techniques: Expressing

Journal: PLoS ONE

Article Title: Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain

doi: 10.1371/journal.pone.0190841

Figure Lengend Snippet: Only genes with an associated microRNA are listed. Critical network genes were dysregulated at 120hr and present in at least one of the top three IPA networks derived from the time-point based network analysis. Blue text indicates that RNAs were also identified in the cluster sharing the greatest overlap with the list of critical network genes: AMY—cluster 4; NAC—cluster 3; PFC: cluster 4. Inset shows temporal expression pattern for the designated cluster. See for a full version of the inset figures. Red upward pointing arrow indicates up-regulation; Green downward pointing arrow indicates down-regulation. Bracketed letters denote membership in cell-type specific gene lists (See ) enriched in the analyzed datasets [a = astrocyte, i = immune related, m = microglia, n = neuron, o = oligodendrocyte.] (Cell specific gene lists were pre-loaded into IPA and automatically scored against all datasets submitted to Core Analysis. Significant enrichment was determined by p value < 0.05 using Fisher’s exact test.) A single asterisk (*) indicates the microRNA was uniquely detected in the indicated brain-region.

Article Snippet: All microRNA microarray data files are available from the National Center for Biotechnology Information Gene Expression Omnibus (NCBI GEO, https://www.ncbi.nlm.nih.gov/geo/ ), accession number GSE90608.

Techniques: Derivative Assay, Expressing

Journal: PLoS ONE

Article Title: Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain

doi: 10.1371/journal.pone.0190841

Figure Lengend Snippet: Hub genes identified in the cluster-based networks and their associated microRNAs.

Article Snippet: All microRNA microarray data files are available from the National Center for Biotechnology Information Gene Expression Omnibus (NCBI GEO, https://www.ncbi.nlm.nih.gov/geo/ ), accession number GSE90608.

Techniques: Expressing