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( A ) PCA of global <t>transcriptomic</t> differences. ( B ) Heatmap of globally DEGs when modeled as ~ PDX_ID + RTS. ( C ) Volcano plot of globally DEGs when modeled by ~RTS alone (red text meets cutoffs of log 2 fold change > 2 or < –2, adjusted P < 0.05). ( D ) Circos plot of differentially regulated lncRNAs (red) with their direct DNA binding targets (black) and differentially regulated lncRNAs (blue) with their DNA binding sites.
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( A ) PCA of global <t>transcriptomic</t> differences. ( B ) Heatmap of globally DEGs when modeled as ~ PDX_ID + RTS. ( C ) Volcano plot of globally DEGs when modeled by ~RTS alone (red text meets cutoffs of log 2 fold change > 2 or < –2, adjusted P < 0.05). ( D ) Circos plot of differentially regulated lncRNAs (red) with their direct DNA binding targets (black) and differentially regulated lncRNAs (blue) with their DNA binding sites.
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( A ) PCA of global transcriptomic differences. ( B ) Heatmap of globally DEGs when modeled as ~ PDX_ID + RTS. ( C ) Volcano plot of globally DEGs when modeled by ~RTS alone (red text meets cutoffs of log 2 fold change > 2 or < –2, adjusted P < 0.05). ( D ) Circos plot of differentially regulated lncRNAs (red) with their direct DNA binding targets (black) and differentially regulated lncRNAs (blue) with their DNA binding sites.

Journal: JCI Insight

Article Title: An in vivo model of glioblastoma radiation resistance identifies long noncoding RNAs and targetable kinases

doi: 10.1172/jci.insight.148717

Figure Lengend Snippet: ( A ) PCA of global transcriptomic differences. ( B ) Heatmap of globally DEGs when modeled as ~ PDX_ID + RTS. ( C ) Volcano plot of globally DEGs when modeled by ~RTS alone (red text meets cutoffs of log 2 fold change > 2 or < –2, adjusted P < 0.05). ( D ) Circos plot of differentially regulated lncRNAs (red) with their direct DNA binding targets (black) and differentially regulated lncRNAs (blue) with their DNA binding sites.

Article Snippet: Of these, existing Affymetrix transcriptomic microarray data were available for 13 PDX lines ( n = 7 sensitive, n = 6 resistant).

Techniques: Binding Assay