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LINE-1 and Alu PMA Assays.

Journal: PLoS ONE

Article Title: Genome-Wide Hypomethylation in Head and Neck Cancer Is More Pronounced in HPV-Negative Tumors and Is Associated with Genomic Instability

doi: 10.1371/journal.pone.0004941

Figure Lengend Snippet: LINE-1 and Alu PMA Assays.

Article Snippet: To assay global methylation levels, we adapted our Pyrosequencing-based Methylation Analysis (PMA) assay to assess methylation of repetitive LINE and SINE ( Alu ) elements, similar to genome-wide methylation assays reported previously .

Techniques: