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met 5a cells  (ATCC)
96
ATCC met 5a cells
(A) Growth inhibitory effects of defactinib on mesothelioma <t>and</t> <t>Met-5A</t> cells. Cell cells were treated with defactnib as indicated for 72 hrs and the viability was assayed with the WST assay. IC 50 values and SE bars (n = 3) are also included. (B) Expression level of the molecules associated with FAK and p53 in mesothelioma cells treated with defactinib as indicated for 24 hrs. The western blot analysis included expression levels of a phosphorylated form of FAK, p53 and AKT, and a cleaved form of caspase-9 and PARP. Tubulin was used as a loading control. The expression of each molecule was quantified with ImageJ software (NIH, Bethesda, MD, USA) with tubulin intensity as a normalized control (see ).
Met 5a Cells, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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round 576  (LGC Standards)
94
LGC Standards round 576
(A) Growth inhibitory effects of defactinib on mesothelioma <t>and</t> <t>Met-5A</t> cells. Cell cells were treated with defactnib as indicated for 72 hrs and the viability was assayed with the WST assay. IC 50 values and SE bars (n = 3) are also included. (B) Expression level of the molecules associated with FAK and p53 in mesothelioma cells treated with defactinib as indicated for 24 hrs. The western blot analysis included expression levels of a phosphorylated form of FAK, p53 and AKT, and a cleaved form of caspase-9 and PARP. Tubulin was used as a loading control. The expression of each molecule was quantified with ImageJ software (NIH, Bethesda, MD, USA) with tubulin intensity as a normalized control (see ).
Round 576, supplied by LGC Standards, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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met12  (MedChemExpress)
94
MedChemExpress met12
(A) Growth inhibitory effects of defactinib on mesothelioma <t>and</t> <t>Met-5A</t> cells. Cell cells were treated with defactnib as indicated for 72 hrs and the viability was assayed with the WST assay. IC 50 values and SE bars (n = 3) are also included. (B) Expression level of the molecules associated with FAK and p53 in mesothelioma cells treated with defactinib as indicated for 24 hrs. The western blot analysis included expression levels of a phosphorylated form of FAK, p53 and AKT, and a cleaved form of caspase-9 and PARP. Tubulin was used as a loading control. The expression of each molecule was quantified with ImageJ software (NIH, Bethesda, MD, USA) with tubulin intensity as a normalized control (see ).
Met12, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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m9 medium  (Valiant Co Ltd)
94
Valiant Co Ltd m9 medium
(A) Growth inhibitory effects of defactinib on mesothelioma <t>and</t> <t>Met-5A</t> cells. Cell cells were treated with defactnib as indicated for 72 hrs and the viability was assayed with the WST assay. IC 50 values and SE bars (n = 3) are also included. (B) Expression level of the molecules associated with FAK and p53 in mesothelioma cells treated with defactinib as indicated for 24 hrs. The western blot analysis included expression levels of a phosphorylated form of FAK, p53 and AKT, and a cleaved form of caspase-9 and PARP. Tubulin was used as a loading control. The expression of each molecule was quantified with ImageJ software (NIH, Bethesda, MD, USA) with tubulin intensity as a normalized control (see ).
M9 Medium, supplied by Valiant Co Ltd, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mp biomedical cat 4510712  (Valiant Co Ltd)
94
Valiant Co Ltd mp biomedical cat 4510712
(A) Growth inhibitory effects of defactinib on mesothelioma <t>and</t> <t>Met-5A</t> cells. Cell cells were treated with defactnib as indicated for 72 hrs and the viability was assayed with the WST assay. IC 50 values and SE bars (n = 3) are also included. (B) Expression level of the molecules associated with FAK and p53 in mesothelioma cells treated with defactinib as indicated for 24 hrs. The western blot analysis included expression levels of a phosphorylated form of FAK, p53 and AKT, and a cleaved form of caspase-9 and PARP. Tubulin was used as a loading control. The expression of each molecule was quantified with ImageJ software (NIH, Bethesda, MD, USA) with tubulin intensity as a normalized control (see ).
Mp Biomedical Cat 4510712, supplied by Valiant Co Ltd, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mesothelial cell line met5a  (ATCC)
96
ATCC mesothelial cell line met5a
(A) Growth inhibitory effects of defactinib on mesothelioma <t>and</t> <t>Met-5A</t> cells. Cell cells were treated with defactnib as indicated for 72 hrs and the viability was assayed with the WST assay. IC 50 values and SE bars (n = 3) are also included. (B) Expression level of the molecules associated with FAK and p53 in mesothelioma cells treated with defactinib as indicated for 24 hrs. The western blot analysis included expression levels of a phosphorylated form of FAK, p53 and AKT, and a cleaved form of caspase-9 and PARP. Tubulin was used as a loading control. The expression of each molecule was quantified with ImageJ software (NIH, Bethesda, MD, USA) with tubulin intensity as a normalized control (see ).
Mesothelial Cell Line Met5a, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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(A) Growth inhibitory effects of defactinib on mesothelioma and Met-5A cells. Cell cells were treated with defactnib as indicated for 72 hrs and the viability was assayed with the WST assay. IC 50 values and SE bars (n = 3) are also included. (B) Expression level of the molecules associated with FAK and p53 in mesothelioma cells treated with defactinib as indicated for 24 hrs. The western blot analysis included expression levels of a phosphorylated form of FAK, p53 and AKT, and a cleaved form of caspase-9 and PARP. Tubulin was used as a loading control. The expression of each molecule was quantified with ImageJ software (NIH, Bethesda, MD, USA) with tubulin intensity as a normalized control (see ).

Journal: PLOS One

Article Title: Strategic selection of MDM2 inhibitors enhances the efficacy of FAK inhibition in mesothelioma based on TP53 genotype

doi: 10.1371/journal.pone.0343551

Figure Lengend Snippet: (A) Growth inhibitory effects of defactinib on mesothelioma and Met-5A cells. Cell cells were treated with defactnib as indicated for 72 hrs and the viability was assayed with the WST assay. IC 50 values and SE bars (n = 3) are also included. (B) Expression level of the molecules associated with FAK and p53 in mesothelioma cells treated with defactinib as indicated for 24 hrs. The western blot analysis included expression levels of a phosphorylated form of FAK, p53 and AKT, and a cleaved form of caspase-9 and PARP. Tubulin was used as a loading control. The expression of each molecule was quantified with ImageJ software (NIH, Bethesda, MD, USA) with tubulin intensity as a normalized control (see ).

Article Snippet: Human mesothelioma cells, NCI-H28, MSTO-211H, NCI-H2052, NCI-H226 and NCI-H2452 cells, and SV40-T antigen-expressing immortalized cells of mesothelium origin, Met-5A cells, were purchased from American Type Culture Collection (Manassas, VA, USA).

Techniques: WST Assay, Expressing, Western Blot, Control, Software

(A) Growth inhibitory effects of nutlin-3a on mesothelioma and Met-5A cells. Cell cells were treated with nutlin-3a as indicated for 72 hrs and the viability was assayed with the WST assay. IC 50 values and SE bars (n = 3) are also included. (B) Expression level of the molecules associated with FAK and p53 in mesothelioma cells treated with nultin-3a as indicated for 24 hrs. The western blot analysis also included expression levels of a phosphorylated form of FAK, p53 and H2AX. Actin was used as a loading control. For phosphorylated H2AX, the blots were exposed for a longer period to ensure the detection of basal signals in untreated cells. The basal intensity therefore differed from that of the RITA experiments in where shorter exposures were used. The expression of each molecule was quantified with ImageJ software (NIH, Bethesda, MD, USA) with actin intensity as a normalized control (see ).

Journal: PLOS One

Article Title: Strategic selection of MDM2 inhibitors enhances the efficacy of FAK inhibition in mesothelioma based on TP53 genotype

doi: 10.1371/journal.pone.0343551

Figure Lengend Snippet: (A) Growth inhibitory effects of nutlin-3a on mesothelioma and Met-5A cells. Cell cells were treated with nutlin-3a as indicated for 72 hrs and the viability was assayed with the WST assay. IC 50 values and SE bars (n = 3) are also included. (B) Expression level of the molecules associated with FAK and p53 in mesothelioma cells treated with nultin-3a as indicated for 24 hrs. The western blot analysis also included expression levels of a phosphorylated form of FAK, p53 and H2AX. Actin was used as a loading control. For phosphorylated H2AX, the blots were exposed for a longer period to ensure the detection of basal signals in untreated cells. The basal intensity therefore differed from that of the RITA experiments in where shorter exposures were used. The expression of each molecule was quantified with ImageJ software (NIH, Bethesda, MD, USA) with actin intensity as a normalized control (see ).

Article Snippet: Human mesothelioma cells, NCI-H28, MSTO-211H, NCI-H2052, NCI-H226 and NCI-H2452 cells, and SV40-T antigen-expressing immortalized cells of mesothelium origin, Met-5A cells, were purchased from American Type Culture Collection (Manassas, VA, USA).

Techniques: WST Assay, Expressing, Western Blot, Control, Software

(A) Growth inhibitory effects of RITA on mesothelioma and Met-5A cells. Cell cells were treated with RITA as indicated for 72 hrs and the viability was assayed with the WST assay. IC 50 values and SE bars (n = 3) are also included. (B) Expression level of the molecules associated with FAK and p53 in mesothelioma cells treated with RITA as indicated for 24 hrs. The western blot analysis included expression levels of a phosphorylated form of FAK, p53 and H2AX. Actin was used as a loading control. For phosphorylated H2AX of MSTO-211H cells, the blot was exposed for a longer period to ensure the detection of basal signals in untreated cells. The expression of each molecule was quantified with ImageJ software (NIH, Bethesda, MD, USA) with actin intensity as a normalized control (see ).

Journal: PLOS One

Article Title: Strategic selection of MDM2 inhibitors enhances the efficacy of FAK inhibition in mesothelioma based on TP53 genotype

doi: 10.1371/journal.pone.0343551

Figure Lengend Snippet: (A) Growth inhibitory effects of RITA on mesothelioma and Met-5A cells. Cell cells were treated with RITA as indicated for 72 hrs and the viability was assayed with the WST assay. IC 50 values and SE bars (n = 3) are also included. (B) Expression level of the molecules associated with FAK and p53 in mesothelioma cells treated with RITA as indicated for 24 hrs. The western blot analysis included expression levels of a phosphorylated form of FAK, p53 and H2AX. Actin was used as a loading control. For phosphorylated H2AX of MSTO-211H cells, the blot was exposed for a longer period to ensure the detection of basal signals in untreated cells. The expression of each molecule was quantified with ImageJ software (NIH, Bethesda, MD, USA) with actin intensity as a normalized control (see ).

Article Snippet: Human mesothelioma cells, NCI-H28, MSTO-211H, NCI-H2052, NCI-H226 and NCI-H2452 cells, and SV40-T antigen-expressing immortalized cells of mesothelium origin, Met-5A cells, were purchased from American Type Culture Collection (Manassas, VA, USA).

Techniques: WST Assay, Expressing, Western Blot, Control, Software