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a) Short- and long-axis views of biventricular meshed geometries of six PPCM patients illustrating the wall thickness of the left and right ventricular free wall and septal wall. In each image, the LV is on the right, and the RV is on the left. Recovery status (R: recovered, N: not recovered), ejection fraction, and survival status (A: alive and D: died) are indicated in the patient code. b) Comparison of the calibrated passive filling curves for each patient. Volume was normalised to unloaded volume V 0 . Compliance of the LV myocardium increased with increase in ejection fraction (numerical value in the model’s name). Model N06D with the lowest ejection fraction of 6% had the stiffest LV myocardium. c) Schematic of coupling of biventricular geometry with circulatory system and LVAD ( Sack et al ., 2018b ). R M : mitral valve resistance, R A : aortic valve resistance, C SA : systemic arterial compliance, R SYS : systemic arterial resistance, C SV : systemic venous compliance, R T: tricuspid valve resistance, R P : pulmonary valve resistance, C PA : pulmonary arterial compliance, R P : pulmonary valve resistance, C P : pulmonary system compliance, LVAD: left ventricular assist device.

Journal: medRxiv

Article Title: Patient-specific in silico prediction of outcomes of partial continuous-flow LVAD treatment in peripartum cardiomyopathy

doi: 10.1101/2024.09.18.24313803

Figure Lengend Snippet: a) Short- and long-axis views of biventricular meshed geometries of six PPCM patients illustrating the wall thickness of the left and right ventricular free wall and septal wall. In each image, the LV is on the right, and the RV is on the left. Recovery status (R: recovered, N: not recovered), ejection fraction, and survival status (A: alive and D: died) are indicated in the patient code. b) Comparison of the calibrated passive filling curves for each patient. Volume was normalised to unloaded volume V 0 . Compliance of the LV myocardium increased with increase in ejection fraction (numerical value in the model’s name). Model N06D with the lowest ejection fraction of 6% had the stiffest LV myocardium. c) Schematic of coupling of biventricular geometry with circulatory system and LVAD ( Sack et al ., 2018b ). R M : mitral valve resistance, R A : aortic valve resistance, C SA : systemic arterial compliance, R SYS : systemic arterial resistance, C SV : systemic venous compliance, R T: tricuspid valve resistance, R P : pulmonary valve resistance, C PA : pulmonary arterial compliance, R P : pulmonary valve resistance, C P : pulmonary system compliance, LVAD: left ventricular assist device.

Article Snippet: The meshed biventricular cardiac geometries were imported into Abaqus CAE (Dassault Systèmes, Providence, USA).

Techniques: Comparison

Representative contour plots displaying the two main trends of the biventricular myofibre stress in PPCM with increasing LVAD speed at end-diastole (ED) and end-systole (ES). (a) Model R45A illustrates the first trend with a decrease in myofibre stress with an increase in LVAD speed at end-diastole but an increase in myofibre stress from 8,000 to 12,000 rpm at end-systole. This was observed for models R45A and N39A. (b) Model N06D illustrates the second trend with a decrease in myofibre stress with increasing LVAD speed both at end-diastole and end-systole, observed for models R20A, N18A, N12A and N06D. (Contour plots for the other patients are displayed in supplemental Figure S1.

Journal: medRxiv

Article Title: Patient-specific in silico prediction of outcomes of partial continuous-flow LVAD treatment in peripartum cardiomyopathy

doi: 10.1101/2024.09.18.24313803

Figure Lengend Snippet: Representative contour plots displaying the two main trends of the biventricular myofibre stress in PPCM with increasing LVAD speed at end-diastole (ED) and end-systole (ES). (a) Model R45A illustrates the first trend with a decrease in myofibre stress with an increase in LVAD speed at end-diastole but an increase in myofibre stress from 8,000 to 12,000 rpm at end-systole. This was observed for models R45A and N39A. (b) Model N06D illustrates the second trend with a decrease in myofibre stress with increasing LVAD speed both at end-diastole and end-systole, observed for models R20A, N18A, N12A and N06D. (Contour plots for the other patients are displayed in supplemental Figure S1.

Article Snippet: The meshed biventricular cardiac geometries were imported into Abaqus CAE (Dassault Systèmes, Providence, USA).

Techniques: