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Sesamin modulates m 6 A methylation and ferroptosis-related markers in aortic tissue. (A) Representative immunohistochemical staining of SREBF1 and <t>METTL3</t> protein expression in aortic sections from each group. (B) Quantification of global m 6 A RNA methylation levels in aortic tissues. (C) Fe 2+ content in aortic tissues determined using an iron assay kit. (D) Immunoblotting analysis of ACSL4, GPX4, and xCT protein levels in aortic tissues. Results are shown as mean ± SD (n = 6 mice per group). ***p < 0.001 vs. Ctrl group; #p < 0.05, ##p < 0.01, ###p < 0.001 vs. AS group.
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Sesamin modulates m 6 A methylation and ferroptosis-related markers in aortic tissue. (A) Representative immunohistochemical staining of SREBF1 and <t>METTL3</t> protein expression in aortic sections from each group. (B) Quantification of global m 6 A RNA methylation levels in aortic tissues. (C) Fe 2+ content in aortic tissues determined using an iron assay kit. (D) Immunoblotting analysis of ACSL4, GPX4, and xCT protein levels in aortic tissues. Results are shown as mean ± SD (n = 6 mice per group). ***p < 0.001 vs. Ctrl group; #p < 0.05, ##p < 0.01, ###p < 0.001 vs. AS group.
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Sesamin modulates m 6 A methylation and ferroptosis-related markers in aortic tissue. (A) Representative immunohistochemical staining of SREBF1 and <t>METTL3</t> protein expression in aortic sections from each group. (B) Quantification of global m 6 A RNA methylation levels in aortic tissues. (C) Fe 2+ content in aortic tissues determined using an iron assay kit. (D) Immunoblotting analysis of ACSL4, GPX4, and xCT protein levels in aortic tissues. Results are shown as mean ± SD (n = 6 mice per group). ***p < 0.001 vs. Ctrl group; #p < 0.05, ##p < 0.01, ###p < 0.001 vs. AS group.
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Sesamin modulates m 6 A methylation and ferroptosis-related markers in aortic tissue. (A) Representative immunohistochemical staining of SREBF1 and <t>METTL3</t> protein expression in aortic sections from each group. (B) Quantification of global m 6 A RNA methylation levels in aortic tissues. (C) Fe 2+ content in aortic tissues determined using an iron assay kit. (D) Immunoblotting analysis of ACSL4, GPX4, and xCT protein levels in aortic tissues. Results are shown as mean ± SD (n = 6 mice per group). ***p < 0.001 vs. Ctrl group; #p < 0.05, ##p < 0.01, ###p < 0.001 vs. AS group.
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Sesamin modulates m 6 A methylation and ferroptosis-related markers in aortic tissue. (A) Representative immunohistochemical staining of SREBF1 and <t>METTL3</t> protein expression in aortic sections from each group. (B) Quantification of global m 6 A RNA methylation levels in aortic tissues. (C) Fe 2+ content in aortic tissues determined using an iron assay kit. (D) Immunoblotting analysis of ACSL4, GPX4, and xCT protein levels in aortic tissues. Results are shown as mean ± SD (n = 6 mice per group). ***p < 0.001 vs. Ctrl group; #p < 0.05, ##p < 0.01, ###p < 0.001 vs. AS group.
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Sesamin modulates m 6 A methylation and ferroptosis-related markers in aortic tissue. (A) Representative immunohistochemical staining of SREBF1 and <t>METTL3</t> protein expression in aortic sections from each group. (B) Quantification of global m 6 A RNA methylation levels in aortic tissues. (C) Fe 2+ content in aortic tissues determined using an iron assay kit. (D) Immunoblotting analysis of ACSL4, GPX4, and xCT protein levels in aortic tissues. Results are shown as mean ± SD (n = 6 mice per group). ***p < 0.001 vs. Ctrl group; #p < 0.05, ##p < 0.01, ###p < 0.001 vs. AS group.
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Sesamin modulates m 6 A methylation and ferroptosis-related markers in aortic tissue. (A) Representative immunohistochemical staining of SREBF1 and <t>METTL3</t> protein expression in aortic sections from each group. (B) Quantification of global m 6 A RNA methylation levels in aortic tissues. (C) Fe 2+ content in aortic tissues determined using an iron assay kit. (D) Immunoblotting analysis of ACSL4, GPX4, and xCT protein levels in aortic tissues. Results are shown as mean ± SD (n = 6 mice per group). ***p < 0.001 vs. Ctrl group; #p < 0.05, ##p < 0.01, ###p < 0.001 vs. AS group.
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Sesamin modulates m 6 A methylation and ferroptosis-related markers in aortic tissue. (A) Representative immunohistochemical staining of SREBF1 and METTL3 protein expression in aortic sections from each group. (B) Quantification of global m 6 A RNA methylation levels in aortic tissues. (C) Fe 2+ content in aortic tissues determined using an iron assay kit. (D) Immunoblotting analysis of ACSL4, GPX4, and xCT protein levels in aortic tissues. Results are shown as mean ± SD (n = 6 mice per group). ***p < 0.001 vs. Ctrl group; #p < 0.05, ##p < 0.01, ###p < 0.001 vs. AS group.

Journal: Frontiers in Cell and Developmental Biology

Article Title: Sesamin attenuates atherosclerosis by alleviating vascular endothelial ferroptosis-related injury via m 6 A-dependent regulation of SREBF1 expression

doi: 10.3389/fcell.2026.1807359

Figure Lengend Snippet: Sesamin modulates m 6 A methylation and ferroptosis-related markers in aortic tissue. (A) Representative immunohistochemical staining of SREBF1 and METTL3 protein expression in aortic sections from each group. (B) Quantification of global m 6 A RNA methylation levels in aortic tissues. (C) Fe 2+ content in aortic tissues determined using an iron assay kit. (D) Immunoblotting analysis of ACSL4, GPX4, and xCT protein levels in aortic tissues. Results are shown as mean ± SD (n = 6 mice per group). ***p < 0.001 vs. Ctrl group; #p < 0.05, ##p < 0.01, ###p < 0.001 vs. AS group.

Article Snippet: Sections were rinsed three times in PBS and treated overnight at 4 °C with primary antibodies targeting SREBF1 (A15586) or METTL3 (A21572) (both at 1:50 dilution; ABclonal, China).

Techniques: Methylation, Immunohistochemical staining, Staining, Expressing, Iron Assay, Western Blot

Sesamin regulates SREBF1 expression through m 6 A RNA methylation in endothelial cells. (A) Quantification of global m 6 A RNA methylation levels in control, ox-LDL, and ox-LDL + sesamin groups. (B) RT–qPCR analysis of SREBF1, METTL3, METTL14, FTO, and YTHDF1 mRNA expression in each group. (C) Western blot analysis of SREBF1 protein expression in control, ox-LDL, and ox-LDL + sesamin–treated cells. (D) Prediction of potential m 6 A modification sites on SREBF1 mRNA using the SRAMP online tool. (E) MeRIP–qPCR analysis of m 6 A enrichment on SREBF1 mRNA in control, ox-LDL, ox-LDL + si-NC, ox-LDL + si-METTL3, and ox-LDL + sesamin groups. (F) Western blot analysis of METTL3 and SREBF1 protein expression in the indicated groups. (G) Actinomycin D chase assay evaluating SREBF1 mRNA stability in the indicated groups. Data are expressed as mean ± SD (n = 3 independent experiments). *p < 0.05, **p < 0.01, ***p < 0.001 vs. control group; #p < 0.05, ##p < 0.01, ###p < 0.001 vs. ox-LDL group; &&&p < 0.001 vs. ox-LDL + si-NC group.

Journal: Frontiers in Cell and Developmental Biology

Article Title: Sesamin attenuates atherosclerosis by alleviating vascular endothelial ferroptosis-related injury via m 6 A-dependent regulation of SREBF1 expression

doi: 10.3389/fcell.2026.1807359

Figure Lengend Snippet: Sesamin regulates SREBF1 expression through m 6 A RNA methylation in endothelial cells. (A) Quantification of global m 6 A RNA methylation levels in control, ox-LDL, and ox-LDL + sesamin groups. (B) RT–qPCR analysis of SREBF1, METTL3, METTL14, FTO, and YTHDF1 mRNA expression in each group. (C) Western blot analysis of SREBF1 protein expression in control, ox-LDL, and ox-LDL + sesamin–treated cells. (D) Prediction of potential m 6 A modification sites on SREBF1 mRNA using the SRAMP online tool. (E) MeRIP–qPCR analysis of m 6 A enrichment on SREBF1 mRNA in control, ox-LDL, ox-LDL + si-NC, ox-LDL + si-METTL3, and ox-LDL + sesamin groups. (F) Western blot analysis of METTL3 and SREBF1 protein expression in the indicated groups. (G) Actinomycin D chase assay evaluating SREBF1 mRNA stability in the indicated groups. Data are expressed as mean ± SD (n = 3 independent experiments). *p < 0.05, **p < 0.01, ***p < 0.001 vs. control group; #p < 0.05, ##p < 0.01, ###p < 0.001 vs. ox-LDL group; &&&p < 0.001 vs. ox-LDL + si-NC group.

Article Snippet: Sections were rinsed three times in PBS and treated overnight at 4 °C with primary antibodies targeting SREBF1 (A15586) or METTL3 (A21572) (both at 1:50 dilution; ABclonal, China).

Techniques: Expressing, Methylation, Control, Quantitative RT-PCR, Western Blot, Modification

Functional validation of the METTL3–SREBF1 pathway in sesamin-mediated suppression of endothelial ferroptosis. (A) Intracellular Fe 2+ levels in control, ox-LDL–treated, ox-LDL + sesamin–treated, ox-LDL + sesamin + si-NC, ox-LDL + sesamin + si-SREBF1, and ox-LDL + sesamin + si-SREBF1 + si-METTL3 groups. (B) Representative images and quantitative analysis of intracellular lipid ROS detected by the C11-BODIPY 581/591 probe in the indicated groups. (C–E) Levels of MDA, SOD activity, and the GSH/GSSG ratio in the indicated groups. (F) Western blot analysis of ferroptosis-related proteins ACSL4, GPX4, and xCT in the indicated groups. Data are presented as mean ± SD (n = 3 independent experiments). ***p < 0.001 vs. control group; ###p < 0.001 vs. ox-LDL group; &&p < 0.01, &&&p < 0.001 vs. ox-LDL + sesamin + si-NC group; $p < 0.05, $$p < 0.01, $$$p < 0.001 vs. ox-LDL + sesamin + si-SREBF1 group.

Journal: Frontiers in Cell and Developmental Biology

Article Title: Sesamin attenuates atherosclerosis by alleviating vascular endothelial ferroptosis-related injury via m 6 A-dependent regulation of SREBF1 expression

doi: 10.3389/fcell.2026.1807359

Figure Lengend Snippet: Functional validation of the METTL3–SREBF1 pathway in sesamin-mediated suppression of endothelial ferroptosis. (A) Intracellular Fe 2+ levels in control, ox-LDL–treated, ox-LDL + sesamin–treated, ox-LDL + sesamin + si-NC, ox-LDL + sesamin + si-SREBF1, and ox-LDL + sesamin + si-SREBF1 + si-METTL3 groups. (B) Representative images and quantitative analysis of intracellular lipid ROS detected by the C11-BODIPY 581/591 probe in the indicated groups. (C–E) Levels of MDA, SOD activity, and the GSH/GSSG ratio in the indicated groups. (F) Western blot analysis of ferroptosis-related proteins ACSL4, GPX4, and xCT in the indicated groups. Data are presented as mean ± SD (n = 3 independent experiments). ***p < 0.001 vs. control group; ###p < 0.001 vs. ox-LDL group; &&p < 0.01, &&&p < 0.001 vs. ox-LDL + sesamin + si-NC group; $p < 0.05, $$p < 0.01, $$$p < 0.001 vs. ox-LDL + sesamin + si-SREBF1 group.

Article Snippet: Sections were rinsed three times in PBS and treated overnight at 4 °C with primary antibodies targeting SREBF1 (A15586) or METTL3 (A21572) (both at 1:50 dilution; ABclonal, China).

Techniques: Functional Assay, Biomarker Discovery, Control, Activity Assay, Western Blot