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Replication stress signature in published bulk tumor cohorts of PC. The association between molecular subtype and replication stress in the ( A ) ICGC RNAseq (n = 94), ( B ) TCGA (n = 112), and ( C ) ICGC <t>microarray</t> (n = 232) cohorts. In the ICGC ( P = .006), TCGA ( P = .009), and ICGC microarray cohorts ( P = .037), high replication stress was significantly enriched for the squamous subtype. High replication stress was defined as the top-ranking quartile in this cohort; P was calculated using the chi-square test.
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Replication stress signature in published bulk tumor cohorts of PC. The association between molecular subtype and replication stress in the ( A ) ICGC RNAseq (n = 94), ( B ) TCGA (n = 112), and ( C ) ICGC microarray (n = 232) cohorts. In the ICGC ( P = .006), TCGA ( P = .009), and ICGC microarray cohorts ( P = .037), high replication stress was significantly enriched for the squamous subtype. High replication stress was defined as the top-ranking quartile in this cohort; P was calculated using the chi-square test.

Journal: Gastroenterology

Article Title: Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer

doi: 10.1053/j.gastro.2020.09.043

Figure Lengend Snippet: Replication stress signature in published bulk tumor cohorts of PC. The association between molecular subtype and replication stress in the ( A ) ICGC RNAseq (n = 94), ( B ) TCGA (n = 112), and ( C ) ICGC microarray (n = 232) cohorts. In the ICGC ( P = .006), TCGA ( P = .009), and ICGC microarray cohorts ( P = .037), high replication stress was significantly enriched for the squamous subtype. High replication stress was defined as the top-ranking quartile in this cohort; P was calculated using the chi-square test.

Article Snippet: Slides were visualized using an Innopsys 710AL infra-red microarray scanner and signals quantified using MAPIX microarray image analysis software (Innopsys).

Techniques: Microarray