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(Left) Dose-dependent effects of <t>macrolide</t> antibiotics on the release of NO from LPS-stimulated murine macrophages. The cells were incubated for 24 h with various concentrations of ERY (A) , RXT (B) , CLT (C) , and AZT (D) . Max doses (250 μM for ERY, RXT and AZT and 62.5 μM for CLT) were adjusted to achieve a cell viability ≥ 80%. Values on the vertical axe represent the percentage of control of NO formation in the culture medium after addition of LPS. (Right) Human in vitro liver microsome stabilities ( n = 3 per time point) for ERY (E) , RXT (F) , CLT (G) , and AZT (H) . Data are means ± STDEV; n = 6 for each concentration and time point.
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(Left) Dose-dependent effects of macrolide antibiotics on the release of NO from LPS-stimulated murine macrophages. The cells were incubated for 24 h with various concentrations of ERY (A) , RXT (B) , CLT (C) , and AZT (D) . Max doses (250 μM for ERY, RXT and AZT and 62.5 μM for CLT) were adjusted to achieve a cell viability ≥ 80%. Values on the vertical axe represent the percentage of control of NO formation in the culture medium after addition of LPS. (Right) Human in vitro liver microsome stabilities ( n = 3 per time point) for ERY (E) , RXT (F) , CLT (G) , and AZT (H) . Data are means ± STDEV; n = 6 for each concentration and time point.

Journal: Frontiers in Pharmacology

Article Title: Exploring the Role of CYP3A4 Mediated Drug Metabolism in the Pharmacological Modulation of Nitric Oxide Production

doi: 10.3389/fphar.2017.00202

Figure Lengend Snippet: (Left) Dose-dependent effects of macrolide antibiotics on the release of NO from LPS-stimulated murine macrophages. The cells were incubated for 24 h with various concentrations of ERY (A) , RXT (B) , CLT (C) , and AZT (D) . Max doses (250 μM for ERY, RXT and AZT and 62.5 μM for CLT) were adjusted to achieve a cell viability ≥ 80%. Values on the vertical axe represent the percentage of control of NO formation in the culture medium after addition of LPS. (Right) Human in vitro liver microsome stabilities ( n = 3 per time point) for ERY (E) , RXT (F) , CLT (G) , and AZT (H) . Data are means ± STDEV; n = 6 for each concentration and time point.

Article Snippet: The characteristics of the clinical nonantimicrobial properties of macrolide therapy include effective doses that are much lower than the minimal inhibitory concentration (i.e., low-dose macrolide therapy) (Nagai et al., ; Fujii et al., ; Kudoh et al., ; Shitrit et al., ).

Techniques: Incubation, Control, In Vitro, Concentration Assay

Characteristics of studies included in meta-analysis of macrolide use in childhood asthma

Journal: Journal of Asthma and Allergy

Article Title: Utility of adjunctive macrolide therapy in treatment of children with asthma: a systematic review and meta-analysis

doi: 10.2147/JAA.S38652

Figure Lengend Snippet: Characteristics of studies included in meta-analysis of macrolide use in childhood asthma

Article Snippet: Kamada et al studied 11 children, and found a statistically significant reduction in daily oral corticosteroid dosage for children receiving macrolide therapy when compared with a placebo group.

Techniques:

Changes in FEV 1 with addition of macrolide

Journal: Journal of Asthma and Allergy

Article Title: Utility of adjunctive macrolide therapy in treatment of children with asthma: a systematic review and meta-analysis

doi: 10.2147/JAA.S38652

Figure Lengend Snippet: Changes in FEV 1 with addition of macrolide

Article Snippet: Kamada et al studied 11 children, and found a statistically significant reduction in daily oral corticosteroid dosage for children receiving macrolide therapy when compared with a placebo group.

Techniques:

Random effects model analysis of adjunctive macrolide use and FEV 1 change in children with asthma. Notes: Grouping by oral corticosteroid use. I 2 = 89.80, Q = 39.23, P < 0.002. Abbreviations: CI, confidence interval; FEV 1 , forced expiratory volume in one second.

Journal: Journal of Asthma and Allergy

Article Title: Utility of adjunctive macrolide therapy in treatment of children with asthma: a systematic review and meta-analysis

doi: 10.2147/JAA.S38652

Figure Lengend Snippet: Random effects model analysis of adjunctive macrolide use and FEV 1 change in children with asthma. Notes: Grouping by oral corticosteroid use. I 2 = 89.80, Q = 39.23, P < 0.002. Abbreviations: CI, confidence interval; FEV 1 , forced expiratory volume in one second.

Article Snippet: Kamada et al studied 11 children, and found a statistically significant reduction in daily oral corticosteroid dosage for children receiving macrolide therapy when compared with a placebo group.

Techniques:

Changes in OCS dose with addition of macrolide

Journal: Journal of Asthma and Allergy

Article Title: Utility of adjunctive macrolide therapy in treatment of children with asthma: a systematic review and meta-analysis

doi: 10.2147/JAA.S38652

Figure Lengend Snippet: Changes in OCS dose with addition of macrolide

Article Snippet: Kamada et al studied 11 children, and found a statistically significant reduction in daily oral corticosteroid dosage for children receiving macrolide therapy when compared with a placebo group.

Techniques:

Random effects model analysis of adjunctive macrolide use and oral steroid dose change in children with asthma. Notes: I 2 = 82.49, Q = 17.14, P < 0.05.

Journal: Journal of Asthma and Allergy

Article Title: Utility of adjunctive macrolide therapy in treatment of children with asthma: a systematic review and meta-analysis

doi: 10.2147/JAA.S38652

Figure Lengend Snippet: Random effects model analysis of adjunctive macrolide use and oral steroid dose change in children with asthma. Notes: I 2 = 82.49, Q = 17.14, P < 0.05.

Article Snippet: Kamada et al studied 11 children, and found a statistically significant reduction in daily oral corticosteroid dosage for children receiving macrolide therapy when compared with a placebo group.

Techniques: