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ht2ar antagonists m100907  (TargetMol)
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TargetMol ht2ar antagonists m100907
Ht2ar Antagonists M100907, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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5 ht2ar antagonists m100907  (TargetMol)
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TargetMol 5 ht2ar antagonists m100907
<t>5‐HT2AR</t> antagonists ketanserin and <t>M100907,</t> as well as the nonselective 5‐HT2AR agonist lisuride, affect SV pools. Representative colour gradient images (range shown in the rectangle below) from live‐cell imaging of sypHy‐expressing neurons treated with vehicle (CTRL) or ketanserin (KTSR) 1 or 5 μM (a), CTRL or M100907 1 or 10 μM (e), and CTRL, serotonin (SER) 10 or 100 μM or lisuride 10 μM (i). Images show cells during baseline recording, stimulation with 40 and 900 APs at 20 Hz and upon NH 4 Cl pulse, in the presence of bafilomycin A1. Scale bar is 10 μM. (b, f, j) Average traces of sypHy fluorescence intensity normalised to minimum (baseline, F 0 ) and maximum (NH 4 Cl pulse, F max ). Total number of recordings per treatment from 3 independent culture preparations is indicated in brackets. Quantification of the RRP (c, g, k) and TRP (d, h, l) fractions of SVs from the respective experiments. In graphs, bars show the mean, whiskers SEM and circles all data points. Statistical significance was assessed by one‐way ANOVA (KTSR: RRP: F (2,24) = 3.294, p = 0.054, TRP: F (2,24) = 21.59, p < 0.001; M100907: RRP: F (2,28) = 3.476, p = 0.045, TRP: F (2,28) = 4.757, p = 0.017; SER + LIS: RRP: F (3,48) = 0.353, p = 0.787, TRP: F (3,48) = 16.12, p < 0.001) with Dunnett's multiple comparisons test CTRL versus each drug (KTSR: TRP: 1 μM p = 0.676, 5 μM p < 0.001; M100907: RRP: 1 μM p = 0.212, 10 μM p = 0.029, TRP: 1 μM p = 0.242, 10 μM p = 0.010; SER + LIS: TRP: SER 10 μM p = 0.829, SER 100 μM p = 0.189, LIS p < 0.001).
5 Ht2ar Antagonists M100907, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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m100907  (Millipore)
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Millipore m100907
<t>5‐HT2AR</t> antagonists ketanserin and <t>M100907,</t> as well as the nonselective 5‐HT2AR agonist lisuride, affect SV pools. Representative colour gradient images (range shown in the rectangle below) from live‐cell imaging of sypHy‐expressing neurons treated with vehicle (CTRL) or ketanserin (KTSR) 1 or 5 μM (a), CTRL or M100907 1 or 10 μM (e), and CTRL, serotonin (SER) 10 or 100 μM or lisuride 10 μM (i). Images show cells during baseline recording, stimulation with 40 and 900 APs at 20 Hz and upon NH 4 Cl pulse, in the presence of bafilomycin A1. Scale bar is 10 μM. (b, f, j) Average traces of sypHy fluorescence intensity normalised to minimum (baseline, F 0 ) and maximum (NH 4 Cl pulse, F max ). Total number of recordings per treatment from 3 independent culture preparations is indicated in brackets. Quantification of the RRP (c, g, k) and TRP (d, h, l) fractions of SVs from the respective experiments. In graphs, bars show the mean, whiskers SEM and circles all data points. Statistical significance was assessed by one‐way ANOVA (KTSR: RRP: F (2,24) = 3.294, p = 0.054, TRP: F (2,24) = 21.59, p < 0.001; M100907: RRP: F (2,28) = 3.476, p = 0.045, TRP: F (2,28) = 4.757, p = 0.017; SER + LIS: RRP: F (3,48) = 0.353, p = 0.787, TRP: F (3,48) = 16.12, p < 0.001) with Dunnett's multiple comparisons test CTRL versus each drug (KTSR: TRP: 1 μM p = 0.676, 5 μM p < 0.001; M100907: RRP: 1 μM p = 0.212, 10 μM p = 0.029, TRP: 1 μM p = 0.242, 10 μM p = 0.010; SER + LIS: TRP: SER 10 μM p = 0.829, SER 100 μM p = 0.189, LIS p < 0.001).
M100907, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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(r)-(+)-α- (2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol (m100907; volinanserin) (cas no. 139290-65-6)  (Millipore)
90
Millipore (r)-(+)-α- (2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol (m100907; volinanserin) (cas no. 139290-65-6)
<t>5‐HT2AR</t> antagonists ketanserin and <t>M100907,</t> as well as the nonselective 5‐HT2AR agonist lisuride, affect SV pools. Representative colour gradient images (range shown in the rectangle below) from live‐cell imaging of sypHy‐expressing neurons treated with vehicle (CTRL) or ketanserin (KTSR) 1 or 5 μM (a), CTRL or M100907 1 or 10 μM (e), and CTRL, serotonin (SER) 10 or 100 μM or lisuride 10 μM (i). Images show cells during baseline recording, stimulation with 40 and 900 APs at 20 Hz and upon NH 4 Cl pulse, in the presence of bafilomycin A1. Scale bar is 10 μM. (b, f, j) Average traces of sypHy fluorescence intensity normalised to minimum (baseline, F 0 ) and maximum (NH 4 Cl pulse, F max ). Total number of recordings per treatment from 3 independent culture preparations is indicated in brackets. Quantification of the RRP (c, g, k) and TRP (d, h, l) fractions of SVs from the respective experiments. In graphs, bars show the mean, whiskers SEM and circles all data points. Statistical significance was assessed by one‐way ANOVA (KTSR: RRP: F (2,24) = 3.294, p = 0.054, TRP: F (2,24) = 21.59, p < 0.001; M100907: RRP: F (2,28) = 3.476, p = 0.045, TRP: F (2,28) = 4.757, p = 0.017; SER + LIS: RRP: F (3,48) = 0.353, p = 0.787, TRP: F (3,48) = 16.12, p < 0.001) with Dunnett's multiple comparisons test CTRL versus each drug (KTSR: TRP: 1 μM p = 0.676, 5 μM p < 0.001; M100907: RRP: 1 μM p = 0.212, 10 μM p = 0.029, TRP: 1 μM p = 0.242, 10 μM p = 0.010; SER + LIS: TRP: SER 10 μM p = 0.829, SER 100 μM p = 0.189, LIS p < 0.001).
(R) (+) α (2,3 Dimethoxyphenyl) 1 [2 (4 Fluorophenyl)Ethyl] 4 Pipidinemethanol (M100907; Volinanserin) (Cas No. 139290 65 6), supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/(r)-(+)-α- (2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol (m100907; volinanserin) (cas no. 139290-65-6)/product/Millipore
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(r)-(+)-α- (2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol (m100907; volinanserin) (cas no. 139290-65-6) - by Bioz Stars, 2026-02
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m100907 (volinanserin  (Millipore)
90
Millipore m100907 (volinanserin
<t>5‐HT2AR</t> antagonists ketanserin and <t>M100907,</t> as well as the nonselective 5‐HT2AR agonist lisuride, affect SV pools. Representative colour gradient images (range shown in the rectangle below) from live‐cell imaging of sypHy‐expressing neurons treated with vehicle (CTRL) or ketanserin (KTSR) 1 or 5 μM (a), CTRL or M100907 1 or 10 μM (e), and CTRL, serotonin (SER) 10 or 100 μM or lisuride 10 μM (i). Images show cells during baseline recording, stimulation with 40 and 900 APs at 20 Hz and upon NH 4 Cl pulse, in the presence of bafilomycin A1. Scale bar is 10 μM. (b, f, j) Average traces of sypHy fluorescence intensity normalised to minimum (baseline, F 0 ) and maximum (NH 4 Cl pulse, F max ). Total number of recordings per treatment from 3 independent culture preparations is indicated in brackets. Quantification of the RRP (c, g, k) and TRP (d, h, l) fractions of SVs from the respective experiments. In graphs, bars show the mean, whiskers SEM and circles all data points. Statistical significance was assessed by one‐way ANOVA (KTSR: RRP: F (2,24) = 3.294, p = 0.054, TRP: F (2,24) = 21.59, p < 0.001; M100907: RRP: F (2,28) = 3.476, p = 0.045, TRP: F (2,28) = 4.757, p = 0.017; SER + LIS: RRP: F (3,48) = 0.353, p = 0.787, TRP: F (3,48) = 16.12, p < 0.001) with Dunnett's multiple comparisons test CTRL versus each drug (KTSR: TRP: 1 μM p = 0.676, 5 μM p < 0.001; M100907: RRP: 1 μM p = 0.212, 10 μM p = 0.029, TRP: 1 μM p = 0.242, 10 μM p = 0.010; SER + LIS: TRP: SER 10 μM p = 0.829, SER 100 μM p = 0.189, LIS p < 0.001).
M100907 (Volinanserin, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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m100907 (volinanserin - by Bioz Stars, 2026-02
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volinanserin (also known as mdl100907 or m100907) [(r)-(+)-α-(2,3dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol  (Adooq Bioscience LLC)
90
Adooq Bioscience LLC volinanserin (also known as mdl100907 or m100907) [(r)-(+)-α-(2,3dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol
<t>5‐HT2AR</t> antagonists ketanserin and <t>M100907,</t> as well as the nonselective 5‐HT2AR agonist lisuride, affect SV pools. Representative colour gradient images (range shown in the rectangle below) from live‐cell imaging of sypHy‐expressing neurons treated with vehicle (CTRL) or ketanserin (KTSR) 1 or 5 μM (a), CTRL or M100907 1 or 10 μM (e), and CTRL, serotonin (SER) 10 or 100 μM or lisuride 10 μM (i). Images show cells during baseline recording, stimulation with 40 and 900 APs at 20 Hz and upon NH 4 Cl pulse, in the presence of bafilomycin A1. Scale bar is 10 μM. (b, f, j) Average traces of sypHy fluorescence intensity normalised to minimum (baseline, F 0 ) and maximum (NH 4 Cl pulse, F max ). Total number of recordings per treatment from 3 independent culture preparations is indicated in brackets. Quantification of the RRP (c, g, k) and TRP (d, h, l) fractions of SVs from the respective experiments. In graphs, bars show the mean, whiskers SEM and circles all data points. Statistical significance was assessed by one‐way ANOVA (KTSR: RRP: F (2,24) = 3.294, p = 0.054, TRP: F (2,24) = 21.59, p < 0.001; M100907: RRP: F (2,28) = 3.476, p = 0.045, TRP: F (2,28) = 4.757, p = 0.017; SER + LIS: RRP: F (3,48) = 0.353, p = 0.787, TRP: F (3,48) = 16.12, p < 0.001) with Dunnett's multiple comparisons test CTRL versus each drug (KTSR: TRP: 1 μM p = 0.676, 5 μM p < 0.001; M100907: RRP: 1 μM p = 0.212, 10 μM p = 0.029, TRP: 1 μM p = 0.242, 10 μM p = 0.010; SER + LIS: TRP: SER 10 μM p = 0.829, SER 100 μM p = 0.189, LIS p < 0.001).
Volinanserin (Also Known As Mdl100907 Or M100907) [(R) (+) α (2,3dimethoxyphenyl) 1 [2 (4 Fluorophenyl)Ethyl] 4 Pipidinemethanol, supplied by Adooq Bioscience LLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/volinanserin (also known as mdl100907 or m100907) [(r)-(+)-α-(2,3dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol/product/Adooq Bioscience LLC
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volinanserin (also known as mdl100907 or m100907) [(r)-(+)-α-(2,3dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol - by Bioz Stars, 2026-02
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m100907  (Toronto Research Chemicals)
90
Toronto Research Chemicals m100907
<t>5‐HT2AR</t> antagonists ketanserin and <t>M100907,</t> as well as the nonselective 5‐HT2AR agonist lisuride, affect SV pools. Representative colour gradient images (range shown in the rectangle below) from live‐cell imaging of sypHy‐expressing neurons treated with vehicle (CTRL) or ketanserin (KTSR) 1 or 5 μM (a), CTRL or M100907 1 or 10 μM (e), and CTRL, serotonin (SER) 10 or 100 μM or lisuride 10 μM (i). Images show cells during baseline recording, stimulation with 40 and 900 APs at 20 Hz and upon NH 4 Cl pulse, in the presence of bafilomycin A1. Scale bar is 10 μM. (b, f, j) Average traces of sypHy fluorescence intensity normalised to minimum (baseline, F 0 ) and maximum (NH 4 Cl pulse, F max ). Total number of recordings per treatment from 3 independent culture preparations is indicated in brackets. Quantification of the RRP (c, g, k) and TRP (d, h, l) fractions of SVs from the respective experiments. In graphs, bars show the mean, whiskers SEM and circles all data points. Statistical significance was assessed by one‐way ANOVA (KTSR: RRP: F (2,24) = 3.294, p = 0.054, TRP: F (2,24) = 21.59, p < 0.001; M100907: RRP: F (2,28) = 3.476, p = 0.045, TRP: F (2,28) = 4.757, p = 0.017; SER + LIS: RRP: F (3,48) = 0.353, p = 0.787, TRP: F (3,48) = 16.12, p < 0.001) with Dunnett's multiple comparisons test CTRL versus each drug (KTSR: TRP: 1 μM p = 0.676, 5 μM p < 0.001; M100907: RRP: 1 μM p = 0.212, 10 μM p = 0.029, TRP: 1 μM p = 0.242, 10 μM p = 0.010; SER + LIS: TRP: SER 10 μM p = 0.829, SER 100 μM p = 0.189, LIS p < 0.001).
M100907, supplied by Toronto Research Chemicals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/m100907/product/Toronto Research Chemicals
Average 90 stars, based on 1 article reviews
m100907 - by Bioz Stars, 2026-02
90/100 stars
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5‐HT2AR antagonists ketanserin and M100907, as well as the nonselective 5‐HT2AR agonist lisuride, affect SV pools. Representative colour gradient images (range shown in the rectangle below) from live‐cell imaging of sypHy‐expressing neurons treated with vehicle (CTRL) or ketanserin (KTSR) 1 or 5 μM (a), CTRL or M100907 1 or 10 μM (e), and CTRL, serotonin (SER) 10 or 100 μM or lisuride 10 μM (i). Images show cells during baseline recording, stimulation with 40 and 900 APs at 20 Hz and upon NH 4 Cl pulse, in the presence of bafilomycin A1. Scale bar is 10 μM. (b, f, j) Average traces of sypHy fluorescence intensity normalised to minimum (baseline, F 0 ) and maximum (NH 4 Cl pulse, F max ). Total number of recordings per treatment from 3 independent culture preparations is indicated in brackets. Quantification of the RRP (c, g, k) and TRP (d, h, l) fractions of SVs from the respective experiments. In graphs, bars show the mean, whiskers SEM and circles all data points. Statistical significance was assessed by one‐way ANOVA (KTSR: RRP: F (2,24) = 3.294, p = 0.054, TRP: F (2,24) = 21.59, p < 0.001; M100907: RRP: F (2,28) = 3.476, p = 0.045, TRP: F (2,28) = 4.757, p = 0.017; SER + LIS: RRP: F (3,48) = 0.353, p = 0.787, TRP: F (3,48) = 16.12, p < 0.001) with Dunnett's multiple comparisons test CTRL versus each drug (KTSR: TRP: 1 μM p = 0.676, 5 μM p < 0.001; M100907: RRP: 1 μM p = 0.212, 10 μM p = 0.029, TRP: 1 μM p = 0.242, 10 μM p = 0.010; SER + LIS: TRP: SER 10 μM p = 0.829, SER 100 μM p = 0.189, LIS p < 0.001).

Journal: Journal of Neurochemistry

Article Title: Serotonergic Psychedelics Rapidly Modulate Evoked Glutamate Release in Cultured Cortical Neurons

doi: 10.1111/jnc.70020

Figure Lengend Snippet: 5‐HT2AR antagonists ketanserin and M100907, as well as the nonselective 5‐HT2AR agonist lisuride, affect SV pools. Representative colour gradient images (range shown in the rectangle below) from live‐cell imaging of sypHy‐expressing neurons treated with vehicle (CTRL) or ketanserin (KTSR) 1 or 5 μM (a), CTRL or M100907 1 or 10 μM (e), and CTRL, serotonin (SER) 10 or 100 μM or lisuride 10 μM (i). Images show cells during baseline recording, stimulation with 40 and 900 APs at 20 Hz and upon NH 4 Cl pulse, in the presence of bafilomycin A1. Scale bar is 10 μM. (b, f, j) Average traces of sypHy fluorescence intensity normalised to minimum (baseline, F 0 ) and maximum (NH 4 Cl pulse, F max ). Total number of recordings per treatment from 3 independent culture preparations is indicated in brackets. Quantification of the RRP (c, g, k) and TRP (d, h, l) fractions of SVs from the respective experiments. In graphs, bars show the mean, whiskers SEM and circles all data points. Statistical significance was assessed by one‐way ANOVA (KTSR: RRP: F (2,24) = 3.294, p = 0.054, TRP: F (2,24) = 21.59, p < 0.001; M100907: RRP: F (2,28) = 3.476, p = 0.045, TRP: F (2,28) = 4.757, p = 0.017; SER + LIS: RRP: F (3,48) = 0.353, p = 0.787, TRP: F (3,48) = 16.12, p < 0.001) with Dunnett's multiple comparisons test CTRL versus each drug (KTSR: TRP: 1 μM p = 0.676, 5 μM p < 0.001; M100907: RRP: 1 μM p = 0.212, 10 μM p = 0.029, TRP: 1 μM p = 0.242, 10 μM p = 0.010; SER + LIS: TRP: SER 10 μM p = 0.829, SER 100 μM p = 0.189, LIS p < 0.001).

Article Snippet: For treatment of cells, the following drugs were used: lysergic acid diethylamide (LSD) fumarate (custom synthesis, Alfarma), N,N ‐dimethyltryptamine (DMT) fumarate (cat. no. 9003568, Cayman Chemical), 4‐hydroxydimethyltryptamine (psilocin, cat. no. 11864, Cayman Chemical), all diluted in 5% DMSO; 5‐HT2AR antagonists M100907 (volinanserin; cat. no. T5389, TargetMol) diluted in DMSO and ketanserin tartrate (cat. no. AG‐CR1‐0014‐M010, AdipoGen Life Sciences) in 2.5% DMSO, serotonin hydrochloride (cat. no. H9523, Sigma‐Aldrich) in H 2 O, lisuride maleate (cat. no. 4052, Tocris), 5‐HT7 rec. antagonist DR4485 hydrochloride (cat. no. 5005, Tocris) in 2% DMSO and 5‐HT1A rec. antagonist NAD299 hydrochloride (cat. no. 3282, Tocris) in H 2 O.

Techniques: Live Cell Imaging, Expressing, Fluorescence