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Core competing endogenous RNA network of miRNA, <t>lncRNA</t> and circRNA in regulating MGMT expression. Arrows denote promotion or positive regulation, while blunt-ended arrows represent inhibition or negative regulation. miRNA/miR, microRNA; lncRNA, long non-coding RNA; circRNA/circ, circular RNA; MGMT, O 6 -methylguanine-DNAmethyltransferase; Sp1, specificity protein 1; <t>HOTAIR,</t> HOX transcript antisense RNA; UCA1, urothelial carcinoma-associated 1; WDR62, WD repeat domain 62.
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Core competing endogenous RNA network of miRNA, <t>lncRNA</t> and circRNA in regulating MGMT expression. Arrows denote promotion or positive regulation, while blunt-ended arrows represent inhibition or negative regulation. miRNA/miR, microRNA; lncRNA, long non-coding RNA; circRNA/circ, circular RNA; MGMT, O 6 -methylguanine-DNAmethyltransferase; Sp1, specificity protein 1; <t>HOTAIR,</t> HOX transcript antisense RNA; UCA1, urothelial carcinoma-associated 1; WDR62, WD repeat domain 62.
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Image Search Results


Core competing endogenous RNA network of miRNA, lncRNA and circRNA in regulating MGMT expression. Arrows denote promotion or positive regulation, while blunt-ended arrows represent inhibition or negative regulation. miRNA/miR, microRNA; lncRNA, long non-coding RNA; circRNA/circ, circular RNA; MGMT, O 6 -methylguanine-DNAmethyltransferase; Sp1, specificity protein 1; HOTAIR, HOX transcript antisense RNA; UCA1, urothelial carcinoma-associated 1; WDR62, WD repeat domain 62.

Journal: Oncology Letters

Article Title: Role of non-coding RNAs in O 6 -methylguanine-DNA methyltransferase-positive glioblastoma (Review)

doi: 10.3892/ol.2026.15550

Figure Lengend Snippet: Core competing endogenous RNA network of miRNA, lncRNA and circRNA in regulating MGMT expression. Arrows denote promotion or positive regulation, while blunt-ended arrows represent inhibition or negative regulation. miRNA/miR, microRNA; lncRNA, long non-coding RNA; circRNA/circ, circular RNA; MGMT, O 6 -methylguanine-DNAmethyltransferase; Sp1, specificity protein 1; HOTAIR, HOX transcript antisense RNA; UCA1, urothelial carcinoma-associated 1; WDR62, WD repeat domain 62.

Article Snippet: Exosome-derived lncRNA HOTAIR from serum has been reported to promote TMZ resistance in GBM cells, whereas knockdown of lncRNA HOTAIR enhances TMZ sensitivity both in vivo and in vitro ( ).

Techniques: Expressing, Inhibition

Schematic diagram illustrating the mechanisms by which lncRNAs TALC and PRADX regulate MGMT expression. Arrows denote promotion or positive regulation, while blunt-ended arrows represent inhibition or negative regulation. lncRNA, long non-coding RNA; MGMT, O 6 -methylguanine-DNA methyltransferase; PRADX, PRC2 and DDX5-associated lncRNA; TALC, temozolomide-associated lncRNA in glioblastoma recurrence; ATF3, activating transcription factor 3; P, phosphorylation; H3K27me3, trimethylation of histone H3 lysine 27; HDACI, histone deacetylase inhibitor; miR, microRNA.

Journal: Oncology Letters

Article Title: Role of non-coding RNAs in O 6 -methylguanine-DNA methyltransferase-positive glioblastoma (Review)

doi: 10.3892/ol.2026.15550

Figure Lengend Snippet: Schematic diagram illustrating the mechanisms by which lncRNAs TALC and PRADX regulate MGMT expression. Arrows denote promotion or positive regulation, while blunt-ended arrows represent inhibition or negative regulation. lncRNA, long non-coding RNA; MGMT, O 6 -methylguanine-DNA methyltransferase; PRADX, PRC2 and DDX5-associated lncRNA; TALC, temozolomide-associated lncRNA in glioblastoma recurrence; ATF3, activating transcription factor 3; P, phosphorylation; H3K27me3, trimethylation of histone H3 lysine 27; HDACI, histone deacetylase inhibitor; miR, microRNA.

Article Snippet: Exosome-derived lncRNA HOTAIR from serum has been reported to promote TMZ resistance in GBM cells, whereas knockdown of lncRNA HOTAIR enhances TMZ sensitivity both in vivo and in vitro ( ).

Techniques: Expressing, Inhibition, Phospho-proteomics, Histone Deacetylase Assay

Core competing endogenous RNA network of miRNA, lncRNA and circRNA in regulating MGMT expression. Arrows denote promotion or positive regulation, while blunt-ended arrows represent inhibition or negative regulation. miRNA/miR, microRNA; lncRNA, long non-coding RNA; circRNA/circ, circular RNA; MGMT, O 6 -methylguanine-DNAmethyltransferase; Sp1, specificity protein 1; HOTAIR, HOX transcript antisense RNA; UCA1, urothelial carcinoma-associated 1; WDR62, WD repeat domain 62.

Journal: Oncology Letters

Article Title: Role of non-coding RNAs in O 6 -methylguanine-DNA methyltransferase-positive glioblastoma (Review)

doi: 10.3892/ol.2026.15550

Figure Lengend Snippet: Core competing endogenous RNA network of miRNA, lncRNA and circRNA in regulating MGMT expression. Arrows denote promotion or positive regulation, while blunt-ended arrows represent inhibition or negative regulation. miRNA/miR, microRNA; lncRNA, long non-coding RNA; circRNA/circ, circular RNA; MGMT, O 6 -methylguanine-DNAmethyltransferase; Sp1, specificity protein 1; HOTAIR, HOX transcript antisense RNA; UCA1, urothelial carcinoma-associated 1; WDR62, WD repeat domain 62.

Article Snippet: Exosome-derived lncRNA HOTAIR from serum has been reported to promote TMZ resistance in GBM cells, whereas knockdown of lncRNA HOTAIR enhances TMZ sensitivity both in vivo and in vitro ( ).

Techniques: Expressing, Inhibition

Schematic diagram illustrating the mechanisms by which lncRNAs TALC and PRADX regulate MGMT expression. Arrows denote promotion or positive regulation, while blunt-ended arrows represent inhibition or negative regulation. lncRNA, long non-coding RNA; MGMT, O 6 -methylguanine-DNA methyltransferase; PRADX, PRC2 and DDX5-associated lncRNA; TALC, temozolomide-associated lncRNA in glioblastoma recurrence; ATF3, activating transcription factor 3; P, phosphorylation; H3K27me3, trimethylation of histone H3 lysine 27; HDACI, histone deacetylase inhibitor; miR, microRNA.

Journal: Oncology Letters

Article Title: Role of non-coding RNAs in O 6 -methylguanine-DNA methyltransferase-positive glioblastoma (Review)

doi: 10.3892/ol.2026.15550

Figure Lengend Snippet: Schematic diagram illustrating the mechanisms by which lncRNAs TALC and PRADX regulate MGMT expression. Arrows denote promotion or positive regulation, while blunt-ended arrows represent inhibition or negative regulation. lncRNA, long non-coding RNA; MGMT, O 6 -methylguanine-DNA methyltransferase; PRADX, PRC2 and DDX5-associated lncRNA; TALC, temozolomide-associated lncRNA in glioblastoma recurrence; ATF3, activating transcription factor 3; P, phosphorylation; H3K27me3, trimethylation of histone H3 lysine 27; HDACI, histone deacetylase inhibitor; miR, microRNA.

Article Snippet: Exosome-derived lncRNA HOTAIR from serum has been reported to promote TMZ resistance in GBM cells, whereas knockdown of lncRNA HOTAIR enhances TMZ sensitivity both in vivo and in vitro ( ).

Techniques: Expressing, Inhibition, Phospho-proteomics, Histone Deacetylase Assay