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Main features of studies with omics application in rodent ischemia and reperfusion injury model

Journal: International Journal of Biological Sciences

Article Title: Molecular Mechanisms of Ischemia/Reperfusion Injury and Graft Dysfunction in Liver Transplantation: Insights from Multi-Omics Studies in Rodent Animal Models

doi: 10.7150/ijbs.109449

Figure Lengend Snippet: Main features of studies with omics application in rodent ischemia and reperfusion injury model

Article Snippet: Hua, China, 2022 , C57BL6 mice/ male/ 8-10 wks/ 6 vs. 6 , 70% WI (left+middle lobe) , IPC/none , Liver/at the end of each treatment , MicroArray/Arraystar Mouse LncRNA Microarray V3.0 , mRNA/ lncRNA/ transcriptomics , 1.IPC+I/R vs. I/R , One-way ANOVA using Dunnett t-test , 167 DE lncRNAs and 108 mRNAs were identified in IPC+I/R groups. KEGG analysis indicated DEGs were enriched in protein processing in the endoplasmic reticulum, antigen processing and presentation, and fructose and mannose metabolism. , Tissue qRT-PCR , GSE192977.

Techniques: Control, Sampling, Comparison, Biomarker Discovery, Microarray, Ubiquitin Proteomics, Functional Assay, Expressing, Protein-Protein interactions, Gene Expression, Migration, Activation Assay, TUNEL Assay, Infection, Construct, Sequencing