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k252a  (MedChemExpress)
94
MedChemExpress k252a
Affinity studies between AS-II and its target p75NTR . (A, B) Coomassie Blue staining and MS-based DARTs sequencing were conducted to identify the target proteins of AS-II. (C) Molecular docking visualization of AS-II binding to p75NTR complex structure. (D) Molecular docking results for p75NTR (PDB: 5ZGG) with AS-II, NSC49652, and <t>K252a.</t> (E) Antiproteolytic effect of p75NTR protein in combination with AS-II (n = 4). (F) Effects of varying concentrations of AS-II on its binding and protease resistance to p75NTR (n = 4). (G) Thermal stability of p75NTR with or without AS-II (n = 4). (H) Binding affinities of AS-II and K252a (at concentrations from 1.5625-100 μM), PD90780 (at concentrations from 1.5625-200 μM) to p75NTR were determined using SPR assay. (I) Predicted binding sites of AS-II to p75NTR. (J) Effects of AS-II (100 μM) on the expression of GSK3β Tyr216 , β-catenin, and MBP in MO3.13 cells transfected with WT or mutant p75NTR (n = 4). Data are presented as mean ± SD; & p < 0.05, && p < 0.01, vs GAPDH band; # p < 0.05, ### p < 0.001, vs Ctrl group; * p < 0.05, ** p < 0.01, vs DMSO group. ns, not significant. Statistical test: Two-group comparisons used Student's t -test (E, G, J), multi-group comparisons used one-way ANOVA with Dunnett's test (F). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
K252a, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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k252a  (Alomone Labs)
93
Alomone Labs k252a
Affinity studies between AS-II and its target p75NTR . (A, B) Coomassie Blue staining and MS-based DARTs sequencing were conducted to identify the target proteins of AS-II. (C) Molecular docking visualization of AS-II binding to p75NTR complex structure. (D) Molecular docking results for p75NTR (PDB: 5ZGG) with AS-II, NSC49652, and <t>K252a.</t> (E) Antiproteolytic effect of p75NTR protein in combination with AS-II (n = 4). (F) Effects of varying concentrations of AS-II on its binding and protease resistance to p75NTR (n = 4). (G) Thermal stability of p75NTR with or without AS-II (n = 4). (H) Binding affinities of AS-II and K252a (at concentrations from 1.5625-100 μM), PD90780 (at concentrations from 1.5625-200 μM) to p75NTR were determined using SPR assay. (I) Predicted binding sites of AS-II to p75NTR. (J) Effects of AS-II (100 μM) on the expression of GSK3β Tyr216 , β-catenin, and MBP in MO3.13 cells transfected with WT or mutant p75NTR (n = 4). Data are presented as mean ± SD; & p < 0.05, && p < 0.01, vs GAPDH band; # p < 0.05, ### p < 0.001, vs Ctrl group; * p < 0.05, ** p < 0.01, vs DMSO group. ns, not significant. Statistical test: Two-group comparisons used Student's t -test (E, G, J), multi-group comparisons used one-way ANOVA with Dunnett's test (F). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
K252a, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/k252a/product/Alomone Labs
Average 93 stars, based on 1 article reviews
k252a - by Bioz Stars, 2026-03
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k252a hy n6732  (MedChemExpress)
94
MedChemExpress k252a hy n6732
Affinity studies between AS-II and its target p75NTR . (A, B) Coomassie Blue staining and MS-based DARTs sequencing were conducted to identify the target proteins of AS-II. (C) Molecular docking visualization of AS-II binding to p75NTR complex structure. (D) Molecular docking results for p75NTR (PDB: 5ZGG) with AS-II, NSC49652, and <t>K252a.</t> (E) Antiproteolytic effect of p75NTR protein in combination with AS-II (n = 4). (F) Effects of varying concentrations of AS-II on its binding and protease resistance to p75NTR (n = 4). (G) Thermal stability of p75NTR with or without AS-II (n = 4). (H) Binding affinities of AS-II and K252a (at concentrations from 1.5625-100 μM), PD90780 (at concentrations from 1.5625-200 μM) to p75NTR were determined using SPR assay. (I) Predicted binding sites of AS-II to p75NTR. (J) Effects of AS-II (100 μM) on the expression of GSK3β Tyr216 , β-catenin, and MBP in MO3.13 cells transfected with WT or mutant p75NTR (n = 4). Data are presented as mean ± SD; & p < 0.05, && p < 0.01, vs GAPDH band; # p < 0.05, ### p < 0.001, vs Ctrl group; * p < 0.05, ** p < 0.01, vs DMSO group. ns, not significant. Statistical test: Two-group comparisons used Student's t -test (E, G, J), multi-group comparisons used one-way ANOVA with Dunnett's test (F). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
K252a Hy N6732, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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k252a k 150  (Alomone Labs)
93
Alomone Labs k252a k 150
Affinity studies between AS-II and its target p75NTR . (A, B) Coomassie Blue staining and MS-based DARTs sequencing were conducted to identify the target proteins of AS-II. (C) Molecular docking visualization of AS-II binding to p75NTR complex structure. (D) Molecular docking results for p75NTR (PDB: 5ZGG) with AS-II, NSC49652, and <t>K252a.</t> (E) Antiproteolytic effect of p75NTR protein in combination with AS-II (n = 4). (F) Effects of varying concentrations of AS-II on its binding and protease resistance to p75NTR (n = 4). (G) Thermal stability of p75NTR with or without AS-II (n = 4). (H) Binding affinities of AS-II and K252a (at concentrations from 1.5625-100 μM), PD90780 (at concentrations from 1.5625-200 μM) to p75NTR were determined using SPR assay. (I) Predicted binding sites of AS-II to p75NTR. (J) Effects of AS-II (100 μM) on the expression of GSK3β Tyr216 , β-catenin, and MBP in MO3.13 cells transfected with WT or mutant p75NTR (n = 4). Data are presented as mean ± SD; & p < 0.05, && p < 0.01, vs GAPDH band; # p < 0.05, ### p < 0.001, vs Ctrl group; * p < 0.05, ** p < 0.01, vs DMSO group. ns, not significant. Statistical test: Two-group comparisons used Student's t -test (E, G, J), multi-group comparisons used one-way ANOVA with Dunnett's test (F). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
K252a K 150, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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k252a k 150 - by Bioz Stars, 2026-03
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k252a  (Cayman Chemical)
90
Cayman Chemical k252a
Affinity studies between AS-II and its target p75NTR . (A, B) Coomassie Blue staining and MS-based DARTs sequencing were conducted to identify the target proteins of AS-II. (C) Molecular docking visualization of AS-II binding to p75NTR complex structure. (D) Molecular docking results for p75NTR (PDB: 5ZGG) with AS-II, NSC49652, and <t>K252a.</t> (E) Antiproteolytic effect of p75NTR protein in combination with AS-II (n = 4). (F) Effects of varying concentrations of AS-II on its binding and protease resistance to p75NTR (n = 4). (G) Thermal stability of p75NTR with or without AS-II (n = 4). (H) Binding affinities of AS-II and K252a (at concentrations from 1.5625-100 μM), PD90780 (at concentrations from 1.5625-200 μM) to p75NTR were determined using SPR assay. (I) Predicted binding sites of AS-II to p75NTR. (J) Effects of AS-II (100 μM) on the expression of GSK3β Tyr216 , β-catenin, and MBP in MO3.13 cells transfected with WT or mutant p75NTR (n = 4). Data are presented as mean ± SD; & p < 0.05, && p < 0.01, vs GAPDH band; # p < 0.05, ### p < 0.001, vs Ctrl group; * p < 0.05, ** p < 0.01, vs DMSO group. ns, not significant. Statistical test: Two-group comparisons used Student's t -test (E, G, J), multi-group comparisons used one-way ANOVA with Dunnett's test (F). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
K252a, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Affinity studies between AS-II and its target p75NTR . (A, B) Coomassie Blue staining and MS-based DARTs sequencing were conducted to identify the target proteins of AS-II. (C) Molecular docking visualization of AS-II binding to p75NTR complex structure. (D) Molecular docking results for p75NTR (PDB: 5ZGG) with AS-II, NSC49652, and K252a. (E) Antiproteolytic effect of p75NTR protein in combination with AS-II (n = 4). (F) Effects of varying concentrations of AS-II on its binding and protease resistance to p75NTR (n = 4). (G) Thermal stability of p75NTR with or without AS-II (n = 4). (H) Binding affinities of AS-II and K252a (at concentrations from 1.5625-100 μM), PD90780 (at concentrations from 1.5625-200 μM) to p75NTR were determined using SPR assay. (I) Predicted binding sites of AS-II to p75NTR. (J) Effects of AS-II (100 μM) on the expression of GSK3β Tyr216 , β-catenin, and MBP in MO3.13 cells transfected with WT or mutant p75NTR (n = 4). Data are presented as mean ± SD; & p < 0.05, && p < 0.01, vs GAPDH band; # p < 0.05, ### p < 0.001, vs Ctrl group; * p < 0.05, ** p < 0.01, vs DMSO group. ns, not significant. Statistical test: Two-group comparisons used Student's t -test (E, G, J), multi-group comparisons used one-way ANOVA with Dunnett's test (F). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)

Journal: Journal of Advanced Research

Article Title: Astragaloside II, a natural saponin, facilitates remyelination in demyelination neurological diseases via p75NTR receptor mediated β-catenin/Id2/MBP signaling axis in oligodendrocyte precursor cells

doi: 10.1016/j.jare.2025.04.028

Figure Lengend Snippet: Affinity studies between AS-II and its target p75NTR . (A, B) Coomassie Blue staining and MS-based DARTs sequencing were conducted to identify the target proteins of AS-II. (C) Molecular docking visualization of AS-II binding to p75NTR complex structure. (D) Molecular docking results for p75NTR (PDB: 5ZGG) with AS-II, NSC49652, and K252a. (E) Antiproteolytic effect of p75NTR protein in combination with AS-II (n = 4). (F) Effects of varying concentrations of AS-II on its binding and protease resistance to p75NTR (n = 4). (G) Thermal stability of p75NTR with or without AS-II (n = 4). (H) Binding affinities of AS-II and K252a (at concentrations from 1.5625-100 μM), PD90780 (at concentrations from 1.5625-200 μM) to p75NTR were determined using SPR assay. (I) Predicted binding sites of AS-II to p75NTR. (J) Effects of AS-II (100 μM) on the expression of GSK3β Tyr216 , β-catenin, and MBP in MO3.13 cells transfected with WT or mutant p75NTR (n = 4). Data are presented as mean ± SD; & p < 0.05, && p < 0.01, vs GAPDH band; # p < 0.05, ### p < 0.001, vs Ctrl group; * p < 0.05, ** p < 0.01, vs DMSO group. ns, not significant. Statistical test: Two-group comparisons used Student's t -test (E, G, J), multi-group comparisons used one-way ANOVA with Dunnett's test (F). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)

Article Snippet: 3,3′,5-Triiodo-L-thyronine (T3, Cat. No. HY-A0070), SKL2001 (Cat. No. HY-101085), PD90780 (Cat. No. HY-110166 ), and K252a (Cat. No. HY-N6732) were obtained from MedChemExpress (Monmouth Junction, NJ, USA).

Techniques: Staining, Sequencing, Binding Assay, SPR Assay, Expressing, Transfection, Mutagenesis