Journal: International Journal of Nanomedicine

Article Title: Lung-Targeted Itraconazole Delivery Using PVA-Based Nano-in-Microparticles for Improved Treatment of Pulmonary Aspergillosis

doi: 10.2147/IJN.S511099

Figure Lengend Snippet: Formulation of Itraconazole (ITZ) Nanoparticles-in-Microparticles (NIM)

Article Snippet: Itraconazole (ITZ) was purchased from SMS Pharmaceuticals Ltd. (India).

Techniques: Formulation, Nano-Suspension

Journal: Molecular Pharmaceutics

Article Title: Glassy Drug Microneedle Array Design: Drug Glass-Forming Ability and Stability

doi: 10.1021/acs.molpharmaceut.4c01067

Figure Lengend Snippet: Representative DSC thermograms of (A) itraconazole, (B) vismodegib, (C) betamethasone dipropionate, (D) zolmitriptan, (E) indomethacin, and (F) estradiol (E2) produced during analysis to determine drug glass-forming ability classification according to criteria reported by Baird et al. .

Article Snippet: Itraconazole (ITZ), zolmitriptan (ZMT), and 17-β-estradiol hemihydrate (E2) were purchased from Kemprotec (UK) Ltd.; indomethacin (IMN) was purchased from Sigma-Aldrich (Ireland) Ltd.; T-zero calorimetry pans were acquired from Waters TA Instruments Ireland (Dublin, Ireland); 1525L adhesive tape was obtained from 3 M, USA; master mold 7000-grade aluminum was provided by SMAE Engineering Workshop, Queen University Belfast (UK) to design a 14 × 14 microneedle array, 500 μm length/height, and 300 μm diameter base; SYLGARD 184 Silicone Elastomer Kit was purchased from Ellsworth Adhesives Limited (UK), and polydimethylsiloxane microneedle molds were manufactured according to the manufacturer’s instructions.

Techniques: Produced

Journal: Molecular Pharmaceutics

Article Title: Glassy Drug Microneedle Array Design: Drug Glass-Forming Ability and Stability

doi: 10.1021/acs.molpharmaceut.4c01067

Figure Lengend Snippet: (A) DSC thermogram with glass transition temperatures indicated. (B) PXRD diffractogram of the cooled-molten samples of itraconazole (ITZ), vismodegib (VDG), betamethasone dipropionate (BMD), indomethacin (IMN), zolmitriptan (ZMT), and estradiol (E2).

Article Snippet: Itraconazole (ITZ), zolmitriptan (ZMT), and 17-β-estradiol hemihydrate (E2) were purchased from Kemprotec (UK) Ltd.; indomethacin (IMN) was purchased from Sigma-Aldrich (Ireland) Ltd.; T-zero calorimetry pans were acquired from Waters TA Instruments Ireland (Dublin, Ireland); 1525L adhesive tape was obtained from 3 M, USA; master mold 7000-grade aluminum was provided by SMAE Engineering Workshop, Queen University Belfast (UK) to design a 14 × 14 microneedle array, 500 μm length/height, and 300 μm diameter base; SYLGARD 184 Silicone Elastomer Kit was purchased from Ellsworth Adhesives Limited (UK), and polydimethylsiloxane microneedle molds were manufactured according to the manufacturer’s instructions.

Techniques:

Journal: Molecular Pharmaceutics

Article Title: Glassy Drug Microneedle Array Design: Drug Glass-Forming Ability and Stability

doi: 10.1021/acs.molpharmaceut.4c01067

Figure Lengend Snippet: PXRD diffractogram of the cooled-molten samples at the time point crystallization was first observed when stored at 25 °C/60% RH; estradiol (E2) at month 1, indomethacin (IMN) and zolmitriptan (ZMT) at week 1. Itraconazole (ITZ), vismodegib (VDG), and betamethasone dipropionate (BMD) retained their glass stability month 3 under conditions of 25 °C/60% RH with no crystallization peak evident.

Article Snippet: Itraconazole (ITZ), zolmitriptan (ZMT), and 17-β-estradiol hemihydrate (E2) were purchased from Kemprotec (UK) Ltd.; indomethacin (IMN) was purchased from Sigma-Aldrich (Ireland) Ltd.; T-zero calorimetry pans were acquired from Waters TA Instruments Ireland (Dublin, Ireland); 1525L adhesive tape was obtained from 3 M, USA; master mold 7000-grade aluminum was provided by SMAE Engineering Workshop, Queen University Belfast (UK) to design a 14 × 14 microneedle array, 500 μm length/height, and 300 μm diameter base; SYLGARD 184 Silicone Elastomer Kit was purchased from Ellsworth Adhesives Limited (UK), and polydimethylsiloxane microneedle molds were manufactured according to the manufacturer’s instructions.

Techniques: Crystallization Assay

Journal: Molecular Pharmaceutics

Article Title: Glassy Drug Microneedle Array Design: Drug Glass-Forming Ability and Stability

doi: 10.1021/acs.molpharmaceut.4c01067

Figure Lengend Snippet: Drug Candidates Investigated Including Their GFA Class Determined Experimentally Using DSC Methodology, 20 Molecular Weight ( M w ), and polar Surface Area (PSA) Collected from PubChem, a the Stability of Drug Microneedles and Cooled-Molten Drug Samples under Respective Storage Conditions, Melting Point ( T m ), and Glass Transition ( T g ) Were Verified by DSC Analysis, and Amorphous Drug Hygroscopicity Determined Experimentally by DVS Analysis

Article Snippet: Itraconazole (ITZ), zolmitriptan (ZMT), and 17-β-estradiol hemihydrate (E2) were purchased from Kemprotec (UK) Ltd.; indomethacin (IMN) was purchased from Sigma-Aldrich (Ireland) Ltd.; T-zero calorimetry pans were acquired from Waters TA Instruments Ireland (Dublin, Ireland); 1525L adhesive tape was obtained from 3 M, USA; master mold 7000-grade aluminum was provided by SMAE Engineering Workshop, Queen University Belfast (UK) to design a 14 × 14 microneedle array, 500 μm length/height, and 300 μm diameter base; SYLGARD 184 Silicone Elastomer Kit was purchased from Ellsworth Adhesives Limited (UK), and polydimethylsiloxane microneedle molds were manufactured according to the manufacturer’s instructions.

Techniques: Molecular Weight, Crystallization Assay