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<t>ISCA2</t> was upregulated and significantly correlated with HNSC progression (A) Univariate Cox regression analysis of CRGs (B , C) Boxplot showing ISCA2 expression in TCGA-first (B) and TCGA-second (C) cohorts (D) Validation of ISCA2 expression by IHC in HNSC and normal tissues (E) Univariate Cox regression analysis of clinical features (F) Multivariate Cox regression analysis of risk factors consisting of ISCA2, gender, age pathologic stage, and alcohol history (G–I) Kaplan-Meier curve showing the association of ISCA2 expression with the 5-year OS (G) , PFI (H) , and DSS (I,J) Association of ISCA2 with the OS in all TCGA HNSC samples as verified GEPIA2 webserver. ****p-value < 0.0001.
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ISCA2 was upregulated and significantly correlated with HNSC progression (A) Univariate Cox regression analysis of CRGs (B , C) Boxplot showing ISCA2 expression in TCGA-first (B) and TCGA-second (C) cohorts (D) Validation of ISCA2 expression by IHC in HNSC and normal tissues (E) Univariate Cox regression analysis of clinical features (F) Multivariate Cox regression analysis of risk factors consisting of ISCA2, gender, age pathologic stage, and alcohol history (G–I) Kaplan-Meier curve showing the association of ISCA2 expression with the 5-year OS (G) , PFI (H) , and DSS (I,J) Association of ISCA2 with the OS in all TCGA HNSC samples as verified GEPIA2 webserver. ****p-value < 0.0001.

Journal: Frontiers in Genetics

Article Title: An original cuproptosis-related genes signature effectively influences the prognosis and immune status of head and neck squamous cell carcinoma

doi: 10.3389/fgene.2022.1084206

Figure Lengend Snippet: ISCA2 was upregulated and significantly correlated with HNSC progression (A) Univariate Cox regression analysis of CRGs (B , C) Boxplot showing ISCA2 expression in TCGA-first (B) and TCGA-second (C) cohorts (D) Validation of ISCA2 expression by IHC in HNSC and normal tissues (E) Univariate Cox regression analysis of clinical features (F) Multivariate Cox regression analysis of risk factors consisting of ISCA2, gender, age pathologic stage, and alcohol history (G–I) Kaplan-Meier curve showing the association of ISCA2 expression with the 5-year OS (G) , PFI (H) , and DSS (I,J) Association of ISCA2 with the OS in all TCGA HNSC samples as verified GEPIA2 webserver. ****p-value < 0.0001.

Article Snippet: The ISCA2 antibody used for immunohistochemistry was HPA030492 (Atlas antibodies, Bromma, Sweden).

Techniques: Expressing, Biomarker Discovery

Expression validation of genes in 12-CRGs signature using RNA-Seq data of LSCC and ANM tissues (A–F) Expression levels of NTHL1 (A) , DNA2 (B) , DLAT (C) , ISCA2 (D) , MTFR1L (E) and POLE (F) .

Journal: Frontiers in Genetics

Article Title: An original cuproptosis-related genes signature effectively influences the prognosis and immune status of head and neck squamous cell carcinoma

doi: 10.3389/fgene.2022.1084206

Figure Lengend Snippet: Expression validation of genes in 12-CRGs signature using RNA-Seq data of LSCC and ANM tissues (A–F) Expression levels of NTHL1 (A) , DNA2 (B) , DLAT (C) , ISCA2 (D) , MTFR1L (E) and POLE (F) .

Article Snippet: The ISCA2 antibody used for immunohistochemistry was HPA030492 (Atlas antibodies, Bromma, Sweden).

Techniques: Expressing, Biomarker Discovery, RNA Sequencing