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Expression of genes SOCS1, PTEN , and PIAS3 in PBMC between SLE patients and healthy controls. (A) SOCS1 mRNA expression between HC and SLE patients non-stimulated, (B) SOCS1 mRNA expression between HC and SLE patients after stimulation with PMA+IONO, (C) PTEN mRNA expression between HC and SLE patients non-stimulated, (D) PTEN mRNA expression between HC and SLE patients after stimulation with PMA+IONO, (E) PIAS3 mRNA expression between HC and SLE patients non-stimulated, (F) PIAS3 mRNA expression between HC and SLE patients after stimulation with PMA+IONO, (G) <t>IL21</t> mRNA expression between HC and SLE patients non-stimulated, (H) IL21 mRNA expression between HC and SLE patients after stimulation with PMA+IONO. Data are shown in median and IQR. p-value was obtained using Mann–Whitney’s U test. Fold change values (2 -ΔΔCT ) are relative to healthy controls in mRNA expression. GAPDH served as internal reference normalized for SOCS1 mRNA, PTEN mRNA, PIAS3 mRNA and IL21 mRNA.
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Expression of genes SOCS1, PTEN , and PIAS3 in PBMC between SLE patients and healthy controls. (A) SOCS1 mRNA expression between HC and SLE patients non-stimulated, (B) SOCS1 mRNA expression between HC and SLE patients after stimulation with PMA+IONO, (C) PTEN mRNA expression between HC and SLE patients non-stimulated, (D) PTEN mRNA expression between HC and SLE patients after stimulation with PMA+IONO, (E) PIAS3 mRNA expression between HC and SLE patients non-stimulated, (F) PIAS3 mRNA expression between HC and SLE patients after stimulation with PMA+IONO, (G) <t>IL21</t> mRNA expression between HC and SLE patients non-stimulated, (H) IL21 mRNA expression between HC and SLE patients after stimulation with PMA+IONO. Data are shown in median and IQR. p-value was obtained using Mann–Whitney’s U test. Fold change values (2 -ΔΔCT ) are relative to healthy controls in mRNA expression. GAPDH served as internal reference normalized for SOCS1 mRNA, PTEN mRNA, PIAS3 mRNA and IL21 mRNA.
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Expression of genes SOCS1, PTEN , and PIAS3 in PBMC between SLE patients and healthy controls. (A) SOCS1 mRNA expression between HC and SLE patients non-stimulated, (B) SOCS1 mRNA expression between HC and SLE patients after stimulation with PMA+IONO, (C) PTEN mRNA expression between HC and SLE patients non-stimulated, (D) PTEN mRNA expression between HC and SLE patients after stimulation with PMA+IONO, (E) PIAS3 mRNA expression between HC and SLE patients non-stimulated, (F) PIAS3 mRNA expression between HC and SLE patients after stimulation with PMA+IONO, (G) IL21 mRNA expression between HC and SLE patients non-stimulated, (H) IL21 mRNA expression between HC and SLE patients after stimulation with PMA+IONO. Data are shown in median and IQR. p-value was obtained using Mann–Whitney’s U test. Fold change values (2 -ΔΔCT ) are relative to healthy controls in mRNA expression. GAPDH served as internal reference normalized for SOCS1 mRNA, PTEN mRNA, PIAS3 mRNA and IL21 mRNA.

Journal: Frontiers in Immunology

Article Title: Aberrant STAT3 activation and overproduction of IL-21 in systemic lupus erythematosus: role of miR-155 and miR-21 in target genes SOCS1, PTEN and PIAS3

doi: 10.3389/fimmu.2026.1664409

Figure Lengend Snippet: Expression of genes SOCS1, PTEN , and PIAS3 in PBMC between SLE patients and healthy controls. (A) SOCS1 mRNA expression between HC and SLE patients non-stimulated, (B) SOCS1 mRNA expression between HC and SLE patients after stimulation with PMA+IONO, (C) PTEN mRNA expression between HC and SLE patients non-stimulated, (D) PTEN mRNA expression between HC and SLE patients after stimulation with PMA+IONO, (E) PIAS3 mRNA expression between HC and SLE patients non-stimulated, (F) PIAS3 mRNA expression between HC and SLE patients after stimulation with PMA+IONO, (G) IL21 mRNA expression between HC and SLE patients non-stimulated, (H) IL21 mRNA expression between HC and SLE patients after stimulation with PMA+IONO. Data are shown in median and IQR. p-value was obtained using Mann–Whitney’s U test. Fold change values (2 -ΔΔCT ) are relative to healthy controls in mRNA expression. GAPDH served as internal reference normalized for SOCS1 mRNA, PTEN mRNA, PIAS3 mRNA and IL21 mRNA.

Article Snippet: TaqMan probes (Applied Biosystems, Foster City, CA, USA) were used for qPCR: SOCS1 (Hs00705164_s1), PTEN (Hs0262621230_s1), PIAS3 (Hs00966035_m1) and IL21 (Hs00222327_m1), using the following incubation conditions: 50°C for 2 minutes, 95°C for 20 seconds and 40 cycles of 95°C for 1 second and 60°C for 20 seconds.

Techniques: Expressing

Protein expression of IL-21, p-STAT3, SOCS1, PTEN and PIAS3. (A) IL-21 expression in HC and SLE patients non-stimulated, (B) p-STAT3 expression in HC and SLE patients non-stimulated, (C) SOCS1 expression in HC and SLE patients non-stimulated, (D) PTEN expression in HC and SLE patients non-stimulated, (E) PIAS3 expression in HC and SLE patients non-stimulated, (F) IL-21 expression after stimulation with PMA+IONO in HC and SLE patients, (G) p-STAT3 expression after stimulation with PMA+IONO in HC and SLE patients, (H) SOCS1 expression after stimulation with PMA+IONO in HC and SLE patients, (I) PTEN expression after stimulation with PMA+IONO in HC and SLE patients, (J) PIAS3 expression after stimulation with PMA+IONO in HC and SLE patients. Data are shown in median and IQR. p-value was obtained through Mann-Whitney’s U test. β-actin served as an internal reference.

Journal: Frontiers in Immunology

Article Title: Aberrant STAT3 activation and overproduction of IL-21 in systemic lupus erythematosus: role of miR-155 and miR-21 in target genes SOCS1, PTEN and PIAS3

doi: 10.3389/fimmu.2026.1664409

Figure Lengend Snippet: Protein expression of IL-21, p-STAT3, SOCS1, PTEN and PIAS3. (A) IL-21 expression in HC and SLE patients non-stimulated, (B) p-STAT3 expression in HC and SLE patients non-stimulated, (C) SOCS1 expression in HC and SLE patients non-stimulated, (D) PTEN expression in HC and SLE patients non-stimulated, (E) PIAS3 expression in HC and SLE patients non-stimulated, (F) IL-21 expression after stimulation with PMA+IONO in HC and SLE patients, (G) p-STAT3 expression after stimulation with PMA+IONO in HC and SLE patients, (H) SOCS1 expression after stimulation with PMA+IONO in HC and SLE patients, (I) PTEN expression after stimulation with PMA+IONO in HC and SLE patients, (J) PIAS3 expression after stimulation with PMA+IONO in HC and SLE patients. Data are shown in median and IQR. p-value was obtained through Mann-Whitney’s U test. β-actin served as an internal reference.

Article Snippet: TaqMan probes (Applied Biosystems, Foster City, CA, USA) were used for qPCR: SOCS1 (Hs00705164_s1), PTEN (Hs0262621230_s1), PIAS3 (Hs00966035_m1) and IL21 (Hs00222327_m1), using the following incubation conditions: 50°C for 2 minutes, 95°C for 20 seconds and 40 cycles of 95°C for 1 second and 60°C for 20 seconds.

Techniques: Expressing

Cytokines IL-21 and IL-17A levels. (A) IL-21 plasma levels in HC and SLE patients, (B) comparison of IL-21 levels between disease activity groups according to Mex-SLEDAI, (C) IL-21 cytokine measurement in the cell culture supernatant of PMA+IONO-stimulated PBMC, (D) IL-17A levels measurement in the cell culture supernatant of PMA+IONO-stimulated PBMC. Data are shown in median and IQR. p-value was obtained through Mann-Whitney’s U test and Kruskal-Wallis with Dunn’s post-hoc , according to the case.

Journal: Frontiers in Immunology

Article Title: Aberrant STAT3 activation and overproduction of IL-21 in systemic lupus erythematosus: role of miR-155 and miR-21 in target genes SOCS1, PTEN and PIAS3

doi: 10.3389/fimmu.2026.1664409

Figure Lengend Snippet: Cytokines IL-21 and IL-17A levels. (A) IL-21 plasma levels in HC and SLE patients, (B) comparison of IL-21 levels between disease activity groups according to Mex-SLEDAI, (C) IL-21 cytokine measurement in the cell culture supernatant of PMA+IONO-stimulated PBMC, (D) IL-17A levels measurement in the cell culture supernatant of PMA+IONO-stimulated PBMC. Data are shown in median and IQR. p-value was obtained through Mann-Whitney’s U test and Kruskal-Wallis with Dunn’s post-hoc , according to the case.

Article Snippet: TaqMan probes (Applied Biosystems, Foster City, CA, USA) were used for qPCR: SOCS1 (Hs00705164_s1), PTEN (Hs0262621230_s1), PIAS3 (Hs00966035_m1) and IL21 (Hs00222327_m1), using the following incubation conditions: 50°C for 2 minutes, 95°C for 20 seconds and 40 cycles of 95°C for 1 second and 60°C for 20 seconds.

Techniques: Clinical Proteomics, Comparison, Activity Assay, Cell Culture

Correlation among miR-155, miR-21, SOCS1 mRNA, PTEN mRNA, PIAS3 mRNA and IL21 mRNA in HC and SLE patients. (A) correlation between the miR-155, miR-21, SOCS1 mRNA, PTEN mRNA, PIAS3 mRNA and IL21 mRNA non-stimulated in HC, (B) correlation between the miR-155, miR-21, SOCS1 mRNA, PTEN mRNA, PIAS3 mRNA and IL21 mRNA after stimulation with PMA+IONO in HC, (C) correlation between the miR-155, miR-21, SOCS1 mRNA, PTEN mRNA, PIAS3 mRNA and IL21 mRNA non-stimulated in SLE patients, (D) correlation between the miR-155, miR-21, SOCS1 mRNA, PTEN mRNA, PIAS3 mRNA and IL21 mRNA after stimulation with PMA+IONO in SLE patients. p-value was obtained using Spearman’s correlation. *p ≤ 0.05, **p ≤ 0.001, ***p ≤ 0.0001.

Journal: Frontiers in Immunology

Article Title: Aberrant STAT3 activation and overproduction of IL-21 in systemic lupus erythematosus: role of miR-155 and miR-21 in target genes SOCS1, PTEN and PIAS3

doi: 10.3389/fimmu.2026.1664409

Figure Lengend Snippet: Correlation among miR-155, miR-21, SOCS1 mRNA, PTEN mRNA, PIAS3 mRNA and IL21 mRNA in HC and SLE patients. (A) correlation between the miR-155, miR-21, SOCS1 mRNA, PTEN mRNA, PIAS3 mRNA and IL21 mRNA non-stimulated in HC, (B) correlation between the miR-155, miR-21, SOCS1 mRNA, PTEN mRNA, PIAS3 mRNA and IL21 mRNA after stimulation with PMA+IONO in HC, (C) correlation between the miR-155, miR-21, SOCS1 mRNA, PTEN mRNA, PIAS3 mRNA and IL21 mRNA non-stimulated in SLE patients, (D) correlation between the miR-155, miR-21, SOCS1 mRNA, PTEN mRNA, PIAS3 mRNA and IL21 mRNA after stimulation with PMA+IONO in SLE patients. p-value was obtained using Spearman’s correlation. *p ≤ 0.05, **p ≤ 0.001, ***p ≤ 0.0001.

Article Snippet: TaqMan probes (Applied Biosystems, Foster City, CA, USA) were used for qPCR: SOCS1 (Hs00705164_s1), PTEN (Hs0262621230_s1), PIAS3 (Hs00966035_m1) and IL21 (Hs00222327_m1), using the following incubation conditions: 50°C for 2 minutes, 95°C for 20 seconds and 40 cycles of 95°C for 1 second and 60°C for 20 seconds.

Techniques: