Review





Similar Products

gene exp ikbkb rn00584379 m1  (Thermo Fisher)
94
Thermo Fisher gene exp ikbkb rn00584379 m1
Gene Exp Ikbkb Rn00584379 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ikbkb/Gene+Exp%2E+Ikbkb%2C+Rn00584379_m1/bio_rxiv__64898__2026__03__27__714441-89-9--1
Average 94 stars, based on 1 article reviews
gene exp ikbkb rn00584379 m1 - by Bioz Stars, 2026-10
94/100 stars
  Buy from Supplier
ikbkb  (Huabio Inc)
86
Huabio Inc ikbkb
Ikbkb, supplied by Huabio Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ikbkb/ikbkb/pmc13253440-81-0-7
Average 86 stars, based on 1 article reviews
ikbkb - by Bioz Stars, 2026-10
86/100 stars
  Buy from Supplier
nemo cdna  (OriGene)
94
OriGene nemo cdna
MZT2A promotes <t>NEMO</t> ubiquitination by inhibiting the deubiquitinating function of OTULIN. A , the level of NEMO ubiquitination in A549 cells overexpressing MZT2A or under hypoxia by Co-IP analysis; n = 3, ∗ p < 0.05 versus control. B , the interaction between MZT2A and OTULIN in A549 cells by Co-IP analysis. C , GST-pull-down result showed that MZT2A could directly interact with OTULIN. D , the protein levels of MZT2A and OTULIN in A549 cells transfected with MZT2A <t>cDNA,</t> OTULIN-specific siRNA, or both MZT2A cDNA and OTULIN-specific siRNA by Western blot analysis. n = 3, ∗ p < 0.05, ∗∗ p < 0.01 versus control. E , the level of NEMO ubiquitination by Co-IP analysis and the level of IKK phosphorylation by Western blot analysis in A549 cells transfected with MZT2A-specific siRNA, OTULIN-specific siRNA, or OTULIN-specific siRNA and MZT2A cDNA. cDNA, complementary DNA; Co-IP, coimmunoprecipitation; GST, glutathione- S -transferase; MZT2A, mitotic spindle–organizing protein 2A; NEMO, NF-κB essential modulator; OTULIN, OTU deubiquitinase with linear linkage specificity.
Nemo Cdna, supplied by OriGene, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ikbkb/IKK+gamma+(IKBKG)+(NM_003639)+Human+Tagged+ORF+Clone/pmc13049933-247-7-18
Average 94 stars, based on 1 article reviews
nemo cdna - by Bioz Stars, 2026-10
94/100 stars
  Buy from Supplier
gene exp ikbkb hs00233284 m1  (Thermo Fisher)
94
Thermo Fisher gene exp ikbkb hs00233284 m1
MZT2A promotes <t>NEMO</t> ubiquitination by inhibiting the deubiquitinating function of OTULIN. A , the level of NEMO ubiquitination in A549 cells overexpressing MZT2A or under hypoxia by Co-IP analysis; n = 3, ∗ p < 0.05 versus control. B , the interaction between MZT2A and OTULIN in A549 cells by Co-IP analysis. C , GST-pull-down result showed that MZT2A could directly interact with OTULIN. D , the protein levels of MZT2A and OTULIN in A549 cells transfected with MZT2A <t>cDNA,</t> OTULIN-specific siRNA, or both MZT2A cDNA and OTULIN-specific siRNA by Western blot analysis. n = 3, ∗ p < 0.05, ∗∗ p < 0.01 versus control. E , the level of NEMO ubiquitination by Co-IP analysis and the level of IKK phosphorylation by Western blot analysis in A549 cells transfected with MZT2A-specific siRNA, OTULIN-specific siRNA, or OTULIN-specific siRNA and MZT2A cDNA. cDNA, complementary DNA; Co-IP, coimmunoprecipitation; GST, glutathione- S -transferase; MZT2A, mitotic spindle–organizing protein 2A; NEMO, NF-κB essential modulator; OTULIN, OTU deubiquitinase with linear linkage specificity.
Gene Exp Ikbkb Hs00233284 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ikbkb/Gene+Exp%2E+IKBKB%2C+Hs00233284_m1/pm41898701-382-8--1
Average 94 stars, based on 1 article reviews
gene exp ikbkb hs00233284 m1 - by Bioz Stars, 2026-10
94/100 stars
  Buy from Supplier
gene exp ikbkb hs01559460 m1  (Thermo Fisher)
94
Thermo Fisher gene exp ikbkb hs01559460 m1
MZT2A promotes <t>NEMO</t> ubiquitination by inhibiting the deubiquitinating function of OTULIN. A , the level of NEMO ubiquitination in A549 cells overexpressing MZT2A or under hypoxia by Co-IP analysis; n = 3, ∗ p < 0.05 versus control. B , the interaction between MZT2A and OTULIN in A549 cells by Co-IP analysis. C , GST-pull-down result showed that MZT2A could directly interact with OTULIN. D , the protein levels of MZT2A and OTULIN in A549 cells transfected with MZT2A <t>cDNA,</t> OTULIN-specific siRNA, or both MZT2A cDNA and OTULIN-specific siRNA by Western blot analysis. n = 3, ∗ p < 0.05, ∗∗ p < 0.01 versus control. E , the level of NEMO ubiquitination by Co-IP analysis and the level of IKK phosphorylation by Western blot analysis in A549 cells transfected with MZT2A-specific siRNA, OTULIN-specific siRNA, or OTULIN-specific siRNA and MZT2A cDNA. cDNA, complementary DNA; Co-IP, coimmunoprecipitation; GST, glutathione- S -transferase; MZT2A, mitotic spindle–organizing protein 2A; NEMO, NF-κB essential modulator; OTULIN, OTU deubiquitinase with linear linkage specificity.
Gene Exp Ikbkb Hs01559460 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ikbkb/Gene+Exp%2E+IKBKB%2C+Hs01559460_m1/pm41895666-68-42-26
Average 94 stars, based on 1 article reviews
gene exp ikbkb hs01559460 m1 - by Bioz Stars, 2026-10
94/100 stars
  Buy from Supplier
ikbkb  (OriGene)
94
OriGene ikbkb
MZT2A promotes <t>NEMO</t> ubiquitination by inhibiting the deubiquitinating function of OTULIN. A , the level of NEMO ubiquitination in A549 cells overexpressing MZT2A or under hypoxia by Co-IP analysis; n = 3, ∗ p < 0.05 versus control. B , the interaction between MZT2A and OTULIN in A549 cells by Co-IP analysis. C , GST-pull-down result showed that MZT2A could directly interact with OTULIN. D , the protein levels of MZT2A and OTULIN in A549 cells transfected with MZT2A <t>cDNA,</t> OTULIN-specific siRNA, or both MZT2A cDNA and OTULIN-specific siRNA by Western blot analysis. n = 3, ∗ p < 0.05, ∗∗ p < 0.01 versus control. E , the level of NEMO ubiquitination by Co-IP analysis and the level of IKK phosphorylation by Western blot analysis in A549 cells transfected with MZT2A-specific siRNA, OTULIN-specific siRNA, or OTULIN-specific siRNA and MZT2A cDNA. cDNA, complementary DNA; Co-IP, coimmunoprecipitation; GST, glutathione- S -transferase; MZT2A, mitotic spindle–organizing protein 2A; NEMO, NF-κB essential modulator; OTULIN, OTU deubiquitinase with linear linkage specificity.
Ikbkb, supplied by OriGene, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ikbkb/IKK+beta+(IKBKB)+(NM_001556)+Human+Tagged+ORF+Clone/bio_rxiv__64898__2026__03__16__712123-181-26-27
Average 94 stars, based on 1 article reviews
ikbkb - by Bioz Stars, 2026-10
94/100 stars
  Buy from Supplier
ikkα  (Bioss)
92
Bioss ikkα
MZT2A promotes <t>NEMO</t> ubiquitination by inhibiting the deubiquitinating function of OTULIN. A , the level of NEMO ubiquitination in A549 cells overexpressing MZT2A or under hypoxia by Co-IP analysis; n = 3, ∗ p < 0.05 versus control. B , the interaction between MZT2A and OTULIN in A549 cells by Co-IP analysis. C , GST-pull-down result showed that MZT2A could directly interact with OTULIN. D , the protein levels of MZT2A and OTULIN in A549 cells transfected with MZT2A <t>cDNA,</t> OTULIN-specific siRNA, or both MZT2A cDNA and OTULIN-specific siRNA by Western blot analysis. n = 3, ∗ p < 0.05, ∗∗ p < 0.01 versus control. E , the level of NEMO ubiquitination by Co-IP analysis and the level of IKK phosphorylation by Western blot analysis in A549 cells transfected with MZT2A-specific siRNA, OTULIN-specific siRNA, or OTULIN-specific siRNA and MZT2A cDNA. cDNA, complementary DNA; Co-IP, coimmunoprecipitation; GST, glutathione- S -transferase; MZT2A, mitotic spindle–organizing protein 2A; NEMO, NF-κB essential modulator; OTULIN, OTU deubiquitinase with linear linkage specificity.
Ikkα, supplied by Bioss, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ikbkb/IKK+alpha+Polyclonal+Antibody/pm41803900-115-21-26
Average 92 stars, based on 1 article reviews
ikkα - by Bioz Stars, 2026-10
92/100 stars
  Buy from Supplier

Image Search Results


MZT2A promotes NEMO ubiquitination by inhibiting the deubiquitinating function of OTULIN. A , the level of NEMO ubiquitination in A549 cells overexpressing MZT2A or under hypoxia by Co-IP analysis; n = 3, ∗ p < 0.05 versus control. B , the interaction between MZT2A and OTULIN in A549 cells by Co-IP analysis. C , GST-pull-down result showed that MZT2A could directly interact with OTULIN. D , the protein levels of MZT2A and OTULIN in A549 cells transfected with MZT2A cDNA, OTULIN-specific siRNA, or both MZT2A cDNA and OTULIN-specific siRNA by Western blot analysis. n = 3, ∗ p < 0.05, ∗∗ p < 0.01 versus control. E , the level of NEMO ubiquitination by Co-IP analysis and the level of IKK phosphorylation by Western blot analysis in A549 cells transfected with MZT2A-specific siRNA, OTULIN-specific siRNA, or OTULIN-specific siRNA and MZT2A cDNA. cDNA, complementary DNA; Co-IP, coimmunoprecipitation; GST, glutathione- S -transferase; MZT2A, mitotic spindle–organizing protein 2A; NEMO, NF-κB essential modulator; OTULIN, OTU deubiquitinase with linear linkage specificity.

Journal: The Journal of Biological Chemistry

Article Title: Mitotic spindle–organizing protein 2A (MZT2A) promotes cisplatin resistance through NEMO ubiquitination and NF-κB activation in lung adenocarcinoma

doi: 10.1016/j.jbc.2026.111330

Figure Lengend Snippet: MZT2A promotes NEMO ubiquitination by inhibiting the deubiquitinating function of OTULIN. A , the level of NEMO ubiquitination in A549 cells overexpressing MZT2A or under hypoxia by Co-IP analysis; n = 3, ∗ p < 0.05 versus control. B , the interaction between MZT2A and OTULIN in A549 cells by Co-IP analysis. C , GST-pull-down result showed that MZT2A could directly interact with OTULIN. D , the protein levels of MZT2A and OTULIN in A549 cells transfected with MZT2A cDNA, OTULIN-specific siRNA, or both MZT2A cDNA and OTULIN-specific siRNA by Western blot analysis. n = 3, ∗ p < 0.05, ∗∗ p < 0.01 versus control. E , the level of NEMO ubiquitination by Co-IP analysis and the level of IKK phosphorylation by Western blot analysis in A549 cells transfected with MZT2A-specific siRNA, OTULIN-specific siRNA, or OTULIN-specific siRNA and MZT2A cDNA. cDNA, complementary DNA; Co-IP, coimmunoprecipitation; GST, glutathione- S -transferase; MZT2A, mitotic spindle–organizing protein 2A; NEMO, NF-κB essential modulator; OTULIN, OTU deubiquitinase with linear linkage specificity.

Article Snippet: Plasmids carrying the human MZT2A cDNA (#RC219963), NEMO cDNA (#RC201743), and their corresponding vector controls were obtained from OriGene.

Techniques: Ubiquitin Proteomics, Co-Immunoprecipitation Assay, Control, Transfection, Western Blot, Phospho-proteomics