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HPV infection leaves clear DNA methylation signature in HNSCCs. MDS plots showing sample clustering grouped by different variables: a HPV status, b organ site, c smoking status, d alcohol consumption. e Heatmap showing the 2410 <t>DMPs</t> associated with HPV status (FDR <0.05, Δβ >20%)
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HPV infection leaves clear DNA methylation signature in HNSCCs. MDS plots showing sample clustering grouped by different variables: a HPV status, b organ site, c smoking status, d alcohol consumption. e Heatmap showing the 2410 DMPs associated with HPV status (FDR <0.05, Δβ >20%)

Journal: Genome Medicine

Article Title: Unique DNA methylation signature in HPV-positive head and neck squamous cell carcinomas

doi: 10.1186/s13073-017-0419-z

Figure Lengend Snippet: HPV infection leaves clear DNA methylation signature in HNSCCs. MDS plots showing sample clustering grouped by different variables: a HPV status, b organ site, c smoking status, d alcohol consumption. e Heatmap showing the 2410 DMPs associated with HPV status (FDR <0.05, Δβ >20%)

Article Snippet: We compared the list of the 1266 genes for which we found HPV(+)-associated DMPs with other DNA methylation changes of HPV(+) HNSCC, obtained with different genome-wide platforms (Illumina Golden Gate or Illumina HumanMethylation27 bead-array, MCIp-Agilent 244 K).

Techniques: Infection, DNA Methylation Assay