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Associations among hematological markers, serum metabolites, and signaling molecules across three chemotherapy cycles (Chemo-1 pre, Chemo-2 pre, Chemo-3 pre). A Correlation matrix showing the relationships between hematological markers and various metabolites. B Correlation matrix between hematological markers and signaling molecules. C Correlation matrix between metabolites and hematological markers Red indicates a positive association, while blue indicates a negative association. The intensity of the color reflects the strength of the association, with darker shades representing stronger correlations. The numbers within the ellipses represent the correlation coefficients. Abbreviations are as follows: <t>HE4</t> (cancer antigen 125), CA125 (cancer antigen 125), WBC (white blood cell), N (neutrophil), M (monocyte), L (lymphocyte), Hb (hemoglobin), and PLT (blood platelet). Statistical significance is indicated for relevant associations ( P <0.05)
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Associations among hematological markers, serum metabolites, and signaling molecules across three chemotherapy cycles (Chemo-1 pre, Chemo-2 pre, Chemo-3 pre). A Correlation matrix showing the relationships between hematological markers and various metabolites. B Correlation matrix between hematological markers and signaling molecules. C Correlation matrix between metabolites and hematological markers Red indicates a positive association, while blue indicates a negative association. The intensity of the color reflects the strength of the association, with darker shades representing stronger correlations. The numbers within the ellipses represent the correlation coefficients. Abbreviations are as follows: HE4 (cancer antigen 125), CA125 (cancer antigen 125), WBC (white blood cell), N (neutrophil), M (monocyte), L (lymphocyte), Hb (hemoglobin), and PLT (blood platelet). Statistical significance is indicated for relevant associations ( P <0.05)

Journal: Journal of Ovarian Research

Article Title: Two cycles of chemotherapy modulate itaconic acid levels via ATF3/TET2/NF-κB pathways in ovarian cancer among Han Chinese women

doi: 10.1186/s13048-026-02074-1

Figure Lengend Snippet: Associations among hematological markers, serum metabolites, and signaling molecules across three chemotherapy cycles (Chemo-1 pre, Chemo-2 pre, Chemo-3 pre). A Correlation matrix showing the relationships between hematological markers and various metabolites. B Correlation matrix between hematological markers and signaling molecules. C Correlation matrix between metabolites and hematological markers Red indicates a positive association, while blue indicates a negative association. The intensity of the color reflects the strength of the association, with darker shades representing stronger correlations. The numbers within the ellipses represent the correlation coefficients. Abbreviations are as follows: HE4 (cancer antigen 125), CA125 (cancer antigen 125), WBC (white blood cell), N (neutrophil), M (monocyte), L (lymphocyte), Hb (hemoglobin), and PLT (blood platelet). Statistical significance is indicated for relevant associations ( P <0.05)

Article Snippet: Quantitative measurement of HE4 was performed using automated chemiluminescent immunoassays (CLIA) on the ARCHITECT i2000SR platform (Abbott Diagnostics, Chicago, IL, USA) according to the manufacturer’s specifications [ ].

Techniques:

Scatter plots and linear correlation analyses between serum HE4 and serum metabolites (citric acid, itaconic acid, aconitic acid, fumaric acid, and malic acid) as well as ATF3 across pre-chemotherapy cycles (Chemo-1 pre, Chemo-2 pre, and Chemo-3 pre). Significant associations ( P <0.05) are indicated. The colors represent the different chemotherapy cycles: Chemo-1 pre (purple), Chemo-2 pre (teal), and Chemo-3 pre (yellow). Abbreviations: HE4, human epididymis protein 4; ATF3, activating transcription factor 3

Journal: Journal of Ovarian Research

Article Title: Two cycles of chemotherapy modulate itaconic acid levels via ATF3/TET2/NF-κB pathways in ovarian cancer among Han Chinese women

doi: 10.1186/s13048-026-02074-1

Figure Lengend Snippet: Scatter plots and linear correlation analyses between serum HE4 and serum metabolites (citric acid, itaconic acid, aconitic acid, fumaric acid, and malic acid) as well as ATF3 across pre-chemotherapy cycles (Chemo-1 pre, Chemo-2 pre, and Chemo-3 pre). Significant associations ( P <0.05) are indicated. The colors represent the different chemotherapy cycles: Chemo-1 pre (purple), Chemo-2 pre (teal), and Chemo-3 pre (yellow). Abbreviations: HE4, human epididymis protein 4; ATF3, activating transcription factor 3

Article Snippet: Quantitative measurement of HE4 was performed using automated chemiluminescent immunoassays (CLIA) on the ARCHITECT i2000SR platform (Abbott Diagnostics, Chicago, IL, USA) according to the manufacturer’s specifications [ ].

Techniques: