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Previously described mechanisms of resistance to anti-HER2 therapies.
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Previously described mechanisms of resistance to anti-HER2 therapies.

Journal: Cancers

Article Title: Novel Therapies and Strategies to Overcome Resistance to Anti-HER2-Targeted Drugs

doi: 10.3390/cancers14184543

Figure Lengend Snippet: Previously described mechanisms of resistance to anti-HER2 therapies.

Article Snippet: Lapatinib (GW572016, Tyverb, GlaxoSmithKline), a dual HER1–HER2 reversible inhibitor, was the first TKI approved for metastatic HER2 BC and is still the only one recommended in combination with endocrine therapy (letrozole) and/or chemotherapy (capecitabine) for hormone receptor-positive (HR+)/HER2+ advanced or metastatic tumors [ ].

Techniques: Expressing, Protein-Protein interactions, Inhibition, Over Expression, Activation Assay, Binding Assay, Functional Assay, Amplification