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High MiR-34a breast cancer associate with lower gene sets variation analysis <t>(GSVA)</t> scores of the gene sets related to cell cycle or cell proliferation in whole METABRIC cohort and each subtype. Upper <t>row:</t> <t>E2F_Targets,</t> middle row: G2M_Checkpoint, lower row: Mitotic_Spindle Hallmark gene sets. GSVA, Gene Set Variant Analysis.
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High MiR-34a breast cancer associate with lower gene sets variation analysis (GSVA) scores of the gene sets related to cell cycle or cell proliferation in whole METABRIC cohort and each subtype. Upper row: E2F_Targets, middle row: G2M_Checkpoint, lower row: Mitotic_Spindle Hallmark gene sets. GSVA, Gene Set Variant Analysis.

Journal: International Journal of Molecular Sciences

Article Title: High Expression of miR-34a Associated with Less Aggressive Cancer Biology but Not with Survival in Breast Cancer

doi: 10.3390/ijms21093045

Figure Lengend Snippet: High MiR-34a breast cancer associate with lower gene sets variation analysis (GSVA) scores of the gene sets related to cell cycle or cell proliferation in whole METABRIC cohort and each subtype. Upper row: E2F_Targets, middle row: G2M_Checkpoint, lower row: Mitotic_Spindle Hallmark gene sets. GSVA, Gene Set Variant Analysis.

Article Snippet: GSVA scoring of Hallmark gene sets, such as E2F_TARGETS, G2M_CHECKPOINT, MITOTIC_SPINDLE, APOPTOSIS, and EPITHELIAL_MESENCHYMAL_ TRANSITION was utilized in this study ( , C, , and ) Broad Institute ( http://software.broadinstitute.org/gsea/index.jsp ) provides the publicly available software to perform Gene set enrichment analysis (GSEA).

Techniques: Variant Assay

High MiR-34a expression tumors enriched the p53 pathway and apoptosis gene sets. ( A ) Expression levels of miR-34a of p53 wildtype or mutant in the whole cohort and in each subtype in the METABRIC cohort. ( B ) Gene set enrichment analysis (GSEA) of p53 pathway gene sets by miR-34a expression in METABRIC and The Cancer Genome Atlas (TCGA) cohort. ( C ) The association between miR-34a expression and GSVA scoring of Apoptosis in METABRIC and TCGA cohort.

Journal: International Journal of Molecular Sciences

Article Title: High Expression of miR-34a Associated with Less Aggressive Cancer Biology but Not with Survival in Breast Cancer

doi: 10.3390/ijms21093045

Figure Lengend Snippet: High MiR-34a expression tumors enriched the p53 pathway and apoptosis gene sets. ( A ) Expression levels of miR-34a of p53 wildtype or mutant in the whole cohort and in each subtype in the METABRIC cohort. ( B ) Gene set enrichment analysis (GSEA) of p53 pathway gene sets by miR-34a expression in METABRIC and The Cancer Genome Atlas (TCGA) cohort. ( C ) The association between miR-34a expression and GSVA scoring of Apoptosis in METABRIC and TCGA cohort.

Article Snippet: GSVA scoring of Hallmark gene sets, such as E2F_TARGETS, G2M_CHECKPOINT, MITOTIC_SPINDLE, APOPTOSIS, and EPITHELIAL_MESENCHYMAL_ TRANSITION was utilized in this study ( , C, , and ) Broad Institute ( http://software.broadinstitute.org/gsea/index.jsp ) provides the publicly available software to perform Gene set enrichment analysis (GSEA).

Techniques: Expressing, Mutagenesis