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Inhibition of <t>CENPE</t> and MPS1 induces aneuploidy in DG75 cells. (A) DG75 cells treated with 50 nM <t>CENPE</t> <t>inhibitor</t> <t>(GSK923295),</t> followed by 2 μM MPS1 inhibitor (AZ3146) treatment showed increase in aneuploidy population after 72 h, in comparison to nontreated control. (B) Table shows number of counted cells, range of chromosomes and statistical analysis of the chromosome counts.
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Inhibition of <t>CENPE</t> and MPS1 induces aneuploidy in DG75 cells. (A) DG75 cells treated with 50 nM <t>CENPE</t> <t>inhibitor</t> <t>(GSK923295),</t> followed by 2 μM MPS1 inhibitor (AZ3146) treatment showed increase in aneuploidy population after 72 h, in comparison to nontreated control. (B) Table shows number of counted cells, range of chromosomes and statistical analysis of the chromosome counts.
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Inhibition of <t>CENPE</t> and MPS1 induces aneuploidy in DG75 cells. (A) DG75 cells treated with 50 nM <t>CENPE</t> <t>inhibitor</t> <t>(GSK923295),</t> followed by 2 μM MPS1 inhibitor (AZ3146) treatment showed increase in aneuploidy population after 72 h, in comparison to nontreated control. (B) Table shows number of counted cells, range of chromosomes and statistical analysis of the chromosome counts.
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Inhibition of <t>CENPE</t> and MPS1 induces aneuploidy in DG75 cells. (A) DG75 cells treated with 50 nM <t>CENPE</t> <t>inhibitor</t> <t>(GSK923295),</t> followed by 2 μM MPS1 inhibitor (AZ3146) treatment showed increase in aneuploidy population after 72 h, in comparison to nontreated control. (B) Table shows number of counted cells, range of chromosomes and statistical analysis of the chromosome counts.
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https://www.bioz.com/result/gsk923295/product/Selleck Chemicals
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Inhibition of CENPE and MPS1 induces aneuploidy in DG75 cells. (A) DG75 cells treated with 50 nM CENPE inhibitor (GSK923295), followed by 2 μM MPS1 inhibitor (AZ3146) treatment showed increase in aneuploidy population after 72 h, in comparison to nontreated control. (B) Table shows number of counted cells, range of chromosomes and statistical analysis of the chromosome counts.

Journal: Journal of Cellular and Molecular Medicine

Article Title: The Overexpression of Collagen Receptor DDR1 is Associated With Chromosome Instability and Aneuploidy in Diffuse Large B‐Cell Lymphoma

doi: 10.1111/jcmm.70318

Figure Lengend Snippet: Inhibition of CENPE and MPS1 induces aneuploidy in DG75 cells. (A) DG75 cells treated with 50 nM CENPE inhibitor (GSK923295), followed by 2 μM MPS1 inhibitor (AZ3146) treatment showed increase in aneuploidy population after 72 h, in comparison to nontreated control. (B) Table shows number of counted cells, range of chromosomes and statistical analysis of the chromosome counts.

Article Snippet: Cells were ‘serum starved’ for 2 h, followed by incubation with 50 nM CENPE inhibitor (GSK923295; Cayman Chemical, Michigan, USA) for 4 h and 2 μM MPS1 inhibitor (AZ3146; ApexBio, Boston, USA) for 2 h. After 72 h, metaphase spreads were prepared.

Techniques: Inhibition, Comparison, Control