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NPL72038-01 and NPL62039-01 accumulated phosphorylated β-catenin; however, they did not significantly affect the β-catenin signaling pathway. (A) Effect of MG132, <t>GS143,</t> and two positive compounds on the levels of β-catenin and phosphorylated β-catenin in HeLa cells. The levels are quantitated and shown under the panel as % of DMSO control. Increased values (>115) are shown in red. (B) Wnt3a (100 ng/mL) increased the level of TCF transcription. (C) Effect of GS143 and two compounds on TCF transcription in HeLa cells. The data are presented as the average (n = 3) ± S.D. The statistical differences among the groups were evaluated using one-way ANOVA. ( p -value: ** < 0.01).
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gs143  (Tocris)
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NPL72038-01 and NPL62039-01 accumulated phosphorylated β-catenin; however, they did not significantly affect the β-catenin signaling pathway. (A) Effect of MG132, <t>GS143,</t> and two positive compounds on the levels of β-catenin and phosphorylated β-catenin in HeLa cells. The levels are quantitated and shown under the panel as % of DMSO control. Increased values (>115) are shown in red. (B) Wnt3a (100 ng/mL) increased the level of TCF transcription. (C) Effect of GS143 and two compounds on TCF transcription in HeLa cells. The data are presented as the average (n = 3) ± S.D. The statistical differences among the groups were evaluated using one-way ANOVA. ( p -value: ** < 0.01).
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NPL72038-01 and NPL62039-01 accumulated phosphorylated β-catenin; however, they did not significantly affect the β-catenin signaling pathway. (A) Effect of MG132, GS143, and two positive compounds on the levels of β-catenin and phosphorylated β-catenin in HeLa cells. The levels are quantitated and shown under the panel as % of DMSO control. Increased values (>115) are shown in red. (B) Wnt3a (100 ng/mL) increased the level of TCF transcription. (C) Effect of GS143 and two compounds on TCF transcription in HeLa cells. The data are presented as the average (n = 3) ± S.D. The statistical differences among the groups were evaluated using one-way ANOVA. ( p -value: ** < 0.01).

Journal: Oncology Research

Article Title: Isolation and characterization of β-transducin repeat-containing protein ligands screened using a high-throughput screening system

doi: 10.32604/or.2023.030240

Figure Lengend Snippet: NPL72038-01 and NPL62039-01 accumulated phosphorylated β-catenin; however, they did not significantly affect the β-catenin signaling pathway. (A) Effect of MG132, GS143, and two positive compounds on the levels of β-catenin and phosphorylated β-catenin in HeLa cells. The levels are quantitated and shown under the panel as % of DMSO control. Increased values (>115) are shown in red. (B) Wnt3a (100 ng/mL) increased the level of TCF transcription. (C) Effect of GS143 and two compounds on TCF transcription in HeLa cells. The data are presented as the average (n = 3) ± S.D. The statistical differences among the groups were evaluated using one-way ANOVA. ( p -value: ** < 0.01).

Article Snippet: After centrifugation (4°C, 9,100 × g , 10 min), and the lysate with mAG-β-TrCP1 protein was mixed with GS143 (Sigma Aldrich, USA) and other test compounds (RIKEN NPDepo chemical library).

Techniques:

NPD5943, NPL42040-01, and NPL 62020-01 show an inhibitory effect in the NF-κB signaling pathway in a dose-dependent manner. (A) Effect of MG132, GS143, and three compounds on TNF-α induced IκBα degradation in HeLa cells. The levels of IκBα and phosphorylated IκBα in HeLa cells after the treatment are shown. The levels are quantitated and shown under the panel as % of DMSO control. (B) Effect of three positive compounds on TNF α induced NF-κB activation of transcription in HeLa cells: Samples were examined in triplicate. The data are presented as the average ± S.D. The statistical differences among the groups were evaluated using one-way ANOVA ( p -value: **** < 0.0001, *** < 0.001, ** < 0.01, * < 0.05).

Journal: Oncology Research

Article Title: Isolation and characterization of β-transducin repeat-containing protein ligands screened using a high-throughput screening system

doi: 10.32604/or.2023.030240

Figure Lengend Snippet: NPD5943, NPL42040-01, and NPL 62020-01 show an inhibitory effect in the NF-κB signaling pathway in a dose-dependent manner. (A) Effect of MG132, GS143, and three compounds on TNF-α induced IκBα degradation in HeLa cells. The levels of IκBα and phosphorylated IκBα in HeLa cells after the treatment are shown. The levels are quantitated and shown under the panel as % of DMSO control. (B) Effect of three positive compounds on TNF α induced NF-κB activation of transcription in HeLa cells: Samples were examined in triplicate. The data are presented as the average ± S.D. The statistical differences among the groups were evaluated using one-way ANOVA ( p -value: **** < 0.0001, *** < 0.001, ** < 0.01, * < 0.05).

Article Snippet: After centrifugation (4°C, 9,100 × g , 10 min), and the lysate with mAG-β-TrCP1 protein was mixed with GS143 (Sigma Aldrich, USA) and other test compounds (RIKEN NPDepo chemical library).

Techniques: Activation Assay