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(A) sgControl PANC1, PANC1 HRI -/- #2, PANC1 PKR -/- #1, PANC1 PERKI -/- #1/2, and PANC1 <t>GCN2</t> -/- #1/2 cells were treated with cisplatin for 16 hours, then a western blot assay was performed using the indicated antibodies. (B) sgControl PANC1, and PANC1 HRI -/- #2 cells were treated with cisplatin for 6 hours, then a western blot assay was performed using the indicated antibodies. (C) FaDu and (D) HT29 cells were transfected with Control or HRI siRNAs. After 24 hours, the FaDu and HT29 cells were treated with cisplatin or PG3 for 16 hours. Western blot analysis was performed using the indicated antibodies. (E) FaDu and (F) HT29 cells were transfected with Control or PERK siRNAs. After 24 hours’ transfection, the FaDu and HT29 cells were treated with cisplatin and TG for 15 or 21 hours, respectively. Western blot analysis was performed using the indicated antibodies.
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(A) sgControl PANC1, PANC1 HRI -/- #2, PANC1 PKR -/- #1, PANC1 PERKI -/- #1/2, and PANC1 GCN2 -/- #1/2 cells were treated with cisplatin for 16 hours, then a western blot assay was performed using the indicated antibodies. (B) sgControl PANC1, and PANC1 HRI -/- #2 cells were treated with cisplatin for 6 hours, then a western blot assay was performed using the indicated antibodies. (C) FaDu and (D) HT29 cells were transfected with Control or HRI siRNAs. After 24 hours, the FaDu and HT29 cells were treated with cisplatin or PG3 for 16 hours. Western blot analysis was performed using the indicated antibodies. (E) FaDu and (F) HT29 cells were transfected with Control or PERK siRNAs. After 24 hours’ transfection, the FaDu and HT29 cells were treated with cisplatin and TG for 15 or 21 hours, respectively. Western blot analysis was performed using the indicated antibodies.

Journal: bioRxiv

Article Title: Integrated stress response activation in combination PG3 and cisplatin-treated TP53 -mutated head and neck squamous carcinoma cells induces potent apoptotic response

doi: 10.64898/2026.09.22.752907

Figure Lengend Snippet: (A) sgControl PANC1, PANC1 HRI -/- #2, PANC1 PKR -/- #1, PANC1 PERKI -/- #1/2, and PANC1 GCN2 -/- #1/2 cells were treated with cisplatin for 16 hours, then a western blot assay was performed using the indicated antibodies. (B) sgControl PANC1, and PANC1 HRI -/- #2 cells were treated with cisplatin for 6 hours, then a western blot assay was performed using the indicated antibodies. (C) FaDu and (D) HT29 cells were transfected with Control or HRI siRNAs. After 24 hours, the FaDu and HT29 cells were treated with cisplatin or PG3 for 16 hours. Western blot analysis was performed using the indicated antibodies. (E) FaDu and (F) HT29 cells were transfected with Control or PERK siRNAs. After 24 hours’ transfection, the FaDu and HT29 cells were treated with cisplatin and TG for 15 or 21 hours, respectively. Western blot analysis was performed using the indicated antibodies.

Article Snippet: The transfer plasmid used are as follows: lentiCas9-Blast (Addgene #52962), non-targeting control gRNA (Addgene #80263), HRI g2 (Addgene #77050), PKR g1 (Addgene #75637), PERK g1 (Addgene #77166), PERK g2 (Addgene #77168), GCN2 g1 (Addgene #75877), and GCN2 g2 (Addgene #75876).

Techniques: Western Blot, Transfection, Control, Analysis