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Glp 1ra, supplied by Cerner Corporation, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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GLP‐1R is expressed within the human myenteric plexus across the upper and lower GI tract. Representative images demonstrating GLP‐1R immuno‐positive cells (green), which co‐localised with PGP9.5 (red) to show myenteric neurons expressing GLP‐1R (orange). Images were taken from the antrum (A), ileum (B), ascending (C), descending (D) and sigmoid colon (E). (F, G) Quantification of GLP‐1R co‐localisation within the myenteric plexus, across GI regions (F; ( F (4, 20) = 2.74, p = 0.0573), G; ( F (4, 20) = 2.71, p = 0.0596)). (H, I) Mander's coefficient was used to <t>quantify</t> <t>GLP‐1</t> receptor expression on neurons (M 1 ; ( F (4, 20) =16.69, p < 0.001), M 2 ; ( F (4, 20) = 15.85, p < 0.0001)). Scale bar = 50 μm, objective 40×. Dotted lines were used to show the myenteric plexus within the muscle layers determined by the morphology of the tissue, evident with DAPI staining. Images were taken from five different patients. Further statistical information is detailed in Table . * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
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GLP‐1R is expressed within the human myenteric plexus across the upper and lower GI tract. Representative images demonstrating GLP‐1R immuno‐positive cells (green), which co‐localised with PGP9.5 (red) to show myenteric neurons expressing GLP‐1R (orange). Images were taken from the antrum (A), ileum (B), ascending (C), descending (D) and sigmoid colon (E). (F, G) Quantification of GLP‐1R co‐localisation within the myenteric plexus, across GI regions (F; ( F (4, 20) = 2.74, p = 0.0573), G; ( F (4, 20) = 2.71, p = 0.0596)). (H, I) Mander's coefficient was used to <t>quantify</t> <t>GLP‐1</t> receptor expression on neurons (M 1 ; ( F (4, 20) =16.69, p < 0.001), M 2 ; ( F (4, 20) = 15.85, p < 0.0001)). Scale bar = 50 μm, objective 40×. Dotted lines were used to show the myenteric plexus within the muscle layers determined by the morphology of the tissue, evident with DAPI staining. Images were taken from five different patients. Further statistical information is detailed in Table . * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
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GLP‐1R is expressed within the human myenteric plexus across the upper and lower GI tract. Representative images demonstrating GLP‐1R immuno‐positive cells (green), which co‐localised with PGP9.5 (red) to show myenteric neurons expressing GLP‐1R (orange). Images were taken from the antrum (A), ileum (B), ascending (C), descending (D) and sigmoid colon (E). (F, G) Quantification of GLP‐1R co‐localisation within the myenteric plexus, across GI regions (F; ( F (4, 20) = 2.74, p = 0.0573), G; ( F (4, 20) = 2.71, p = 0.0596)). (H, I) Mander's coefficient was used to <t>quantify</t> <t>GLP‐1</t> receptor expression on neurons (M 1 ; ( F (4, 20) =16.69, p < 0.001), M 2 ; ( F (4, 20) = 15.85, p < 0.0001)). Scale bar = 50 μm, objective 40×. Dotted lines were used to show the myenteric plexus within the muscle layers determined by the morphology of the tissue, evident with DAPI staining. Images were taken from five different patients. Further statistical information is detailed in Table . * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
Glp, supplied by Drucker Diagnostics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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GLP‐1R is expressed within the human myenteric plexus across the upper and lower GI tract. Representative images demonstrating GLP‐1R immuno‐positive cells (green), which co‐localised with PGP9.5 (red) to show myenteric neurons expressing GLP‐1R (orange). Images were taken from the antrum (A), ileum (B), ascending (C), descending (D) and sigmoid colon (E). (F, G) Quantification of GLP‐1R co‐localisation within the myenteric plexus, across GI regions (F; ( F (4, 20) = 2.74, p = 0.0573), G; ( F (4, 20) = 2.71, p = 0.0596)). (H, I) Mander's coefficient was used to <t>quantify</t> <t>GLP‐1</t> receptor expression on neurons (M 1 ; ( F (4, 20) =16.69, p < 0.001), M 2 ; ( F (4, 20) = 15.85, p < 0.0001)). Scale bar = 50 μm, objective 40×. Dotted lines were used to show the myenteric plexus within the muscle layers determined by the morphology of the tissue, evident with DAPI staining. Images were taken from five different patients. Further statistical information is detailed in Table . * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
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GLP‐1R is expressed within the human myenteric plexus across the upper and lower GI tract. Representative images demonstrating GLP‐1R immuno‐positive cells (green), which co‐localised with PGP9.5 (red) to show myenteric neurons expressing GLP‐1R (orange). Images were taken from the antrum (A), ileum (B), ascending (C), descending (D) and sigmoid colon (E). (F, G) Quantification of GLP‐1R co‐localisation within the myenteric plexus, across GI regions (F; ( F (4, 20) = 2.74, p = 0.0573), G; ( F (4, 20) = 2.71, p = 0.0596)). (H, I) Mander's coefficient was used to <t>quantify</t> <t>GLP‐1</t> receptor expression on neurons (M 1 ; ( F (4, 20) =16.69, p < 0.001), M 2 ; ( F (4, 20) = 15.85, p < 0.0001)). Scale bar = 50 μm, objective 40×. Dotted lines were used to show the myenteric plexus within the muscle layers determined by the morphology of the tissue, evident with DAPI staining. Images were taken from five different patients. Further statistical information is detailed in Table . * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
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Image Search Results


GLP‐1R is expressed within the human myenteric plexus across the upper and lower GI tract. Representative images demonstrating GLP‐1R immuno‐positive cells (green), which co‐localised with PGP9.5 (red) to show myenteric neurons expressing GLP‐1R (orange). Images were taken from the antrum (A), ileum (B), ascending (C), descending (D) and sigmoid colon (E). (F, G) Quantification of GLP‐1R co‐localisation within the myenteric plexus, across GI regions (F; ( F (4, 20) = 2.74, p = 0.0573), G; ( F (4, 20) = 2.71, p = 0.0596)). (H, I) Mander's coefficient was used to quantify GLP‐1 receptor expression on neurons (M 1 ; ( F (4, 20) =16.69, p < 0.001), M 2 ; ( F (4, 20) = 15.85, p < 0.0001)). Scale bar = 50 μm, objective 40×. Dotted lines were used to show the myenteric plexus within the muscle layers determined by the morphology of the tissue, evident with DAPI staining. Images were taken from five different patients. Further statistical information is detailed in Table . * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.

Journal: Journal of Neurochemistry

Article Title: Systematic Characterisation of GLP ‐ 1R in Human Enteric Nervous System: Implications for GLP ‐1 as a Key Regulator of Colonic Activity

doi: 10.1111/jnc.70461

Figure Lengend Snippet: GLP‐1R is expressed within the human myenteric plexus across the upper and lower GI tract. Representative images demonstrating GLP‐1R immuno‐positive cells (green), which co‐localised with PGP9.5 (red) to show myenteric neurons expressing GLP‐1R (orange). Images were taken from the antrum (A), ileum (B), ascending (C), descending (D) and sigmoid colon (E). (F, G) Quantification of GLP‐1R co‐localisation within the myenteric plexus, across GI regions (F; ( F (4, 20) = 2.74, p = 0.0573), G; ( F (4, 20) = 2.71, p = 0.0596)). (H, I) Mander's coefficient was used to quantify GLP‐1 receptor expression on neurons (M 1 ; ( F (4, 20) =16.69, p < 0.001), M 2 ; ( F (4, 20) = 15.85, p < 0.0001)). Scale bar = 50 μm, objective 40×. Dotted lines were used to show the myenteric plexus within the muscle layers determined by the morphology of the tissue, evident with DAPI staining. Images were taken from five different patients. Further statistical information is detailed in Table . * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.

Article Snippet: Peripherally produced GLP‐1, synthesised by L‐cells, exists in two forms: GLP‐1‐ 7‐37 and GLP‐1‐ 7‐36 and has an important role in local GI physiology (Drucker ; Holst et al. ).

Techniques: Expressing, Staining

GLP‐1R is expressed within the human myenteric plexus across the upper and lower GI tract. Representative images demonstrating GLP‐1R immuno‐positive cells (green), which co‐localised with PGP9.5 (red) to show myenteric neurons expressing GLP‐1R (orange). Images were taken from the antrum (A), ileum (B), ascending (C), descending (D) and sigmoid colon (E). (F, G) Quantification of GLP‐1R co‐localisation within the myenteric plexus, across GI regions (F; ( F (4, 20) = 2.74, p = 0.0573), G; ( F (4, 20) = 2.71, p = 0.0596)). (H, I) Mander's coefficient was used to quantify GLP‐1 receptor expression on neurons (M 1 ; ( F (4, 20) =16.69, p < 0.001), M 2 ; ( F (4, 20) = 15.85, p < 0.0001)). Scale bar = 50 μm, objective 40×. Dotted lines were used to show the myenteric plexus within the muscle layers determined by the morphology of the tissue, evident with DAPI staining. Images were taken from five different patients. Further statistical information is detailed in Table . * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.

Journal: Journal of Neurochemistry

Article Title: Systematic Characterisation of GLP ‐ 1R in Human Enteric Nervous System: Implications for GLP ‐1 as a Key Regulator of Colonic Activity

doi: 10.1111/jnc.70461

Figure Lengend Snippet: GLP‐1R is expressed within the human myenteric plexus across the upper and lower GI tract. Representative images demonstrating GLP‐1R immuno‐positive cells (green), which co‐localised with PGP9.5 (red) to show myenteric neurons expressing GLP‐1R (orange). Images were taken from the antrum (A), ileum (B), ascending (C), descending (D) and sigmoid colon (E). (F, G) Quantification of GLP‐1R co‐localisation within the myenteric plexus, across GI regions (F; ( F (4, 20) = 2.74, p = 0.0573), G; ( F (4, 20) = 2.71, p = 0.0596)). (H, I) Mander's coefficient was used to quantify GLP‐1 receptor expression on neurons (M 1 ; ( F (4, 20) =16.69, p < 0.001), M 2 ; ( F (4, 20) = 15.85, p < 0.0001)). Scale bar = 50 μm, objective 40×. Dotted lines were used to show the myenteric plexus within the muscle layers determined by the morphology of the tissue, evident with DAPI staining. Images were taken from five different patients. Further statistical information is detailed in Table . * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.

Article Snippet: Peripherally produced GLP‐1, synthesised by L‐cells, exists in two forms: GLP‐1‐ 7‐37 and GLP‐1‐ 7‐36 and has an important role in local GI physiology (Drucker ; Holst et al. ).

Techniques: Expressing, Staining