Journal: Nature Communications

Article Title: Long-term brain pressure monitoring via a discrete microimplant; a first-in-human safety and initial efficacy trial in adults and children with hydrocephalus

doi: 10.1038/s41467-026-70864-8

Figure Lengend Snippet: A Immunohistochemistry of sheep brain tissue of the round shunt tubing adjacent to the sensor at 6 months post implantation (scale bar 2.5 mm) (6 sheep had histology performed). Green staining shows neurons stained with NeuN and indicates no widespread neuronal loss. Yellow shows quiescent microglia (IBA-1), indicating stabilisation of the tissue response at 6 months post-implantation. Pink shows astrocytes (GFAP) indicating minimal glial encapsulation. B Schematic showing the placement of the sensor directly within the parenchyma via a separate burr hole from the shunt. C Post-operative MRI image illustrating an approximate 22 mm artifact associated with the sensor. D Post-operative CT image showing the sensor adjacent to a shunt catheter within the cortex.

Article Snippet: Rabbit polyclonal, primary antibodies used were: glial fibrillary acidic protein (GFAP), 1:1000 (Dako, Z0334), ionized calcium-binding adapter protein (IBA-1), 1:500 (Wako 019-19741), and collagen IV (Col4A), 1:300 (Biorbyt 340147).

Techniques: Immunohistochemistry, Staining, Encapsulation