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Image Search Results
Journal: Journal of Functional Foods
Article Title: Coeloglossum viride var. bracteatum extract improves cognitive deficits by restoring BDNF, FGF2 levels and suppressing RIP1/RIP3/MLKL-mediated neuroinflammation in a 5xFAD mouse model of Alzheimer’s disease
doi: 10.1016/j.jff.2021.104612
Figure Lengend Snippet: Fig. 3. FGF2-Akt and RIP1/RIP3/MLKL signaling may be involved in CE-mediated improvement in 5xFAD mice. (A) Western blot results of FGF2, BDNF/TrkB signaling pathway and PI3K/Akt signaling pathway-related proteins in hippocampus and prefrontal cortex. Quantitative results of Western blot are shown in the right panel. (B) Protein levels of regulators associated with necroptosis signaling pathways such as TBK1, RIP1/3 and MLKL, as well as markers for neurons (MAP2), astrocytes (GFAP) and glial (IBA1) in hippocampal and prefrontal cortex samples from 5xFAD mice were detected by Western blot. Two-way ANOVA, post hoc Bonferroni’s multiple comparison tests were performed in this figure. *, p < 0.05; **, p < 0.01; ***, p < 0.001; n.s, not significant.
Article Snippet: Anti phospho-Akt (Ser473) (#4060S), Akt (Akt, #9272S), Bcl-2 (#3498S), phospho-TrkB (#4619 T),
Techniques: Western Blot, Protein-Protein interactions, Comparison