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MMN ranks higher than working memory and ventricular volume in comparison of endophenotype ranking values (ERV SNP ) of schizophrenia candidate endophenotypes The graph shows a comparison of SNP-based endophenotype ranking values (ERV SNP ) of MMN compared to ERV SNP s of Rey Auditory Verbal Learning Task (RAVLT) immediate recall, RAVLT delayed recall, and brain lateral ventricular volume (LVV). The color scale indicates the ERV strength: a good endophenotype would sit in darker red or darker blue areas, indicating that it has a high degree of pleiotropy with the disease and is strongly heritable itself. ERV here has a maximum value of 0.447, given a SNP-based heritability ( h 2 SNP ) for schizophrenia of 0.2002 ( <xref ref-type=Pardiñas et al., 2018 ). The shaded confidence areas in gray indicate the SEs of the endophenotype heritability estimates ( h 2 SNP ) along the x axis and of the genetic overlap between the endophenotype and schizophrenia along the y axis. The ERV is a standardized genetic covariance and does not have units. " width="100%" height="100%">

Journal: Cell Reports

Article Title: Transcriptome-wide association study reveals two genes that influence mismatch negativity

doi: 10.1016/j.celrep.2021.108868

Figure Lengend Snippet: MMN ranks higher than working memory and ventricular volume in comparison of endophenotype ranking values (ERV SNP ) of schizophrenia candidate endophenotypes The graph shows a comparison of SNP-based endophenotype ranking values (ERV SNP ) of MMN compared to ERV SNP s of Rey Auditory Verbal Learning Task (RAVLT) immediate recall, RAVLT delayed recall, and brain lateral ventricular volume (LVV). The color scale indicates the ERV strength: a good endophenotype would sit in darker red or darker blue areas, indicating that it has a high degree of pleiotropy with the disease and is strongly heritable itself. ERV here has a maximum value of 0.447, given a SNP-based heritability ( h 2 SNP ) for schizophrenia of 0.2002 ( Pardiñas et al., 2018 ). The shaded confidence areas in gray indicate the SEs of the endophenotype heritability estimates ( h 2 SNP ) along the x axis and of the genetic overlap between the endophenotype and schizophrenia along the y axis. The ERV is a standardized genetic covariance and does not have units.

Article Snippet: Genome-wide Human SNP Array genotype data (Affymetrix 6.0) , European Bioinformatics Institute, Psychosis Endophenotypes International Consortium , https://www.ebi.ac.uk/ega/dacs/EGAC00001000205.

Techniques:

Journal: Cell Reports

Article Title: Transcriptome-wide association study reveals two genes that influence mismatch negativity

doi: 10.1016/j.celrep.2021.108868

Figure Lengend Snippet:

Article Snippet: Genome-wide Human SNP Array genotype data (Affymetrix 6.0) , European Bioinformatics Institute, Psychosis Endophenotypes International Consortium , https://www.ebi.ac.uk/ega/dacs/EGAC00001000205.

Techniques: Expressing, Genome Wide, Software, Generated