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Single-cell long-read sequencing (scLRS) enhances tumor cell resolution by integrating methods for detecting splicing alterations and genetic variants. Schematic representation of how scLRS can visualize and combine multiple information types within the same cells to improve tumor cell resolution. Created in BioRender. Byrne, A. (2026) https://BioRender.com/mrmobm6 .

Journal: Frontiers in Oncology

Article Title: Beyond counting: how single-cell long-read sequencing turns transcriptome complexity into precision targets

doi: 10.3389/fonc.2026.1800370

Figure Lengend Snippet: Single-cell long-read sequencing (scLRS) enhances tumor cell resolution by integrating methods for detecting splicing alterations and genetic variants. Schematic representation of how scLRS can visualize and combine multiple information types within the same cells to improve tumor cell resolution. Created in BioRender. Byrne, A. (2026) https://BioRender.com/mrmobm6 .

Article Snippet: Adopting third-generation long-read sequencing platforms, such as those developed by Pacific Biosciences (PacBio) and Oxford Nanopore Technologies (ONT), offers a solution to overcome this limitation and deepen our understanding of the transcriptome.

Techniques: Single Cell, Sequencing