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Shanghai Macklin Biochemical
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Astellas
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Nippon Kayaku
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Fisher Scientific
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Advanced Biomatrix Inc
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2026-07
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Sarstedt
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Servicebio Inc
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Macklin Inc
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Shanghai Macklin Biochemical
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2026-07
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Pfizer Inc
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Journal: International Journal of Nanomedicine
Article Title: Size-Dependent Layered Double Hydroxide Nanoparticles Promote Osteogenesis and Bone Regeneration via METTL3-Dependent N6-Methyladenosine Modification of Runx2 mRNA
doi: 10.2147/IJN.S611081
Figure Lengend Snippet: In vivo bone regeneration using a GelMA-LDH composite hydrogel. ( A ) FE-SEM images revealing the highly porous, interconnected microstructure of pure GelMA and GelMA-LDH hydrogels. ( B ) Representative 3D reconstructed micro-CT images of calvarial defects 12 weeks post-implantation in GelMA and GelMA-LDH groups. ( C and D ) Quantitative morphometric analysis of bone volume/tissue volume (BV/TV) and bone mineral density (BMD) from micro-CT data. ( E ) Histological evaluation by H&E and Masson’s Trichrome staining. ( F and G ) Immunofluorescence staining and quantitative analysis of RUNX2 and METTL3 in bone tissue sections from the defect areas. Data are presented as mean ± SD. ***p < 0.001, **p < 0.01.
Article Snippet:
Techniques: In Vivo, Micro-CT, Staining, Immunofluorescence