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Apolipoprotein E (APOE) and Galectin-3 (Gal-3) are elevated in aqueous humor (AH) of patients with glaucoma. ( A ) APOE levels were significantly elevated in the AH of glaucoma patients compared to controls (2.72 vs. 0.85 µg/ml, P < 0.0001). ( B ) Gal-3 levels were significantly elevated in the AH of glaucoma patients compared to controls (2.89 vs. 1.45 ng/ml, P < 0.001).

Journal: Scientific Reports

Article Title: The utility of aqueous and serum apolipoprotein E and galectin-3 as biomarkers of neuroinflammation in glaucoma

doi: 10.1038/s41598-026-45007-0

Figure Lengend Snippet: Apolipoprotein E (APOE) and Galectin-3 (Gal-3) are elevated in aqueous humor (AH) of patients with glaucoma. ( A ) APOE levels were significantly elevated in the AH of glaucoma patients compared to controls (2.72 vs. 0.85 µg/ml, P < 0.0001). ( B ) Gal-3 levels were significantly elevated in the AH of glaucoma patients compared to controls (2.89 vs. 1.45 ng/ml, P < 0.001).

Article Snippet: Fig. 1 Apolipoprotein E (APOE) and Galectin-3 (Gal-3) are elevated in aqueous humor (AH) of patients with glaucoma. ( A ) APOE levels were significantly elevated in the AH of glaucoma patients compared to controls (2.72 vs. 0.85 μg/ml, P < 0.0001). ( B ) Gal-3 levels were significantly elevated in the AH of glaucoma patients compared to controls (2.89 vs. 1.45 ng/ml, P < 0.001).

Techniques:

There is a moderate positive association between levels of aqueous humor (AH) Apolipoprotein E (APOE) and Galectin-3 (Gal-3) in ( A ) the overall glaucoma cohort ( R = 0.44, P < 0.0001) and ( B ) the subgroup of glaucoma patients with primary open angle glaucoma and normal tension glaucoma.

Journal: Scientific Reports

Article Title: The utility of aqueous and serum apolipoprotein E and galectin-3 as biomarkers of neuroinflammation in glaucoma

doi: 10.1038/s41598-026-45007-0

Figure Lengend Snippet: There is a moderate positive association between levels of aqueous humor (AH) Apolipoprotein E (APOE) and Galectin-3 (Gal-3) in ( A ) the overall glaucoma cohort ( R = 0.44, P < 0.0001) and ( B ) the subgroup of glaucoma patients with primary open angle glaucoma and normal tension glaucoma.

Article Snippet: Fig. 1 Apolipoprotein E (APOE) and Galectin-3 (Gal-3) are elevated in aqueous humor (AH) of patients with glaucoma. ( A ) APOE levels were significantly elevated in the AH of glaucoma patients compared to controls (2.72 vs. 0.85 μg/ml, P < 0.0001). ( B ) Gal-3 levels were significantly elevated in the AH of glaucoma patients compared to controls (2.89 vs. 1.45 ng/ml, P < 0.001).

Techniques:

Apolipoprotein E (APOE) but not Galectin-3 (Gal-3) is elevated in the serum of patients with glaucoma. ( A ) APOE levels were significantly elevated in the serum of glaucoma patients compared to controls (58.7 µg/ml vs. 30.2 µg/ml; P < 0.0001). ( B ) Gal-3 levels were similar between glaucoma patients and controls (25.5 vs. 25.7 ng/ml, P = 0.92).

Journal: Scientific Reports

Article Title: The utility of aqueous and serum apolipoprotein E and galectin-3 as biomarkers of neuroinflammation in glaucoma

doi: 10.1038/s41598-026-45007-0

Figure Lengend Snippet: Apolipoprotein E (APOE) but not Galectin-3 (Gal-3) is elevated in the serum of patients with glaucoma. ( A ) APOE levels were significantly elevated in the serum of glaucoma patients compared to controls (58.7 µg/ml vs. 30.2 µg/ml; P < 0.0001). ( B ) Gal-3 levels were similar between glaucoma patients and controls (25.5 vs. 25.7 ng/ml, P = 0.92).

Article Snippet: Fig. 1 Apolipoprotein E (APOE) and Galectin-3 (Gal-3) are elevated in aqueous humor (AH) of patients with glaucoma. ( A ) APOE levels were significantly elevated in the AH of glaucoma patients compared to controls (2.72 vs. 0.85 μg/ml, P < 0.0001). ( B ) Gal-3 levels were significantly elevated in the AH of glaucoma patients compared to controls (2.89 vs. 1.45 ng/ml, P < 0.001).

Techniques: