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gene exp g6pc hs00609178 m1  (Thermo Fisher)
94
Thermo Fisher gene exp g6pc hs00609178 m1
A Insulin clearance diminishes over time in devices cultured in the insulin resistance (“IR”) medium formulation, compared to physiological media. Data are presented as the average of n = 8 devices per media condition across N = 3 experiments, with error bars representing standard deviation and statistical comparison via multiple Mann-Whitney tests with FDR correction. B Gluconeogenesis gene expression ( PCK1, <t>G6PC</t> ) is significantly increased in IR devices relative to physiological control devices, measured via RT-qPCR on Day 12 in culture from n = 4 devices across N = 2 experiments. Changes in genes associated with fatty acid transport and synthesis ( FASN and FABP1 ) are upregulated to a lesser degree. Error bars represent standard deviation from average values. For each gene, a Mann-Whitney test was used to compare between the two media conditions. C Glucose production is increased in IR devices, measured over 24 h from Day 13 to Day 14 of device culture. Data are presented as the average of n = 8 devices per media condition, with error bars representing standard deviation. A Mann-Whitney test was used to compare between the two media conditions. D Row-normalized heatmap of cytokines, chemokines, and growth factors assayed via Luminex from cell culture supernatant collected on Day 10 of device culture across N = 3 experiments. Each row represents one device; n = 25 and 27 total devices for the physiological and IR conditions, respectively. Analyte labels in black indicate significant differences between physiological and IR conditions (P-adj <0.05). E Partial least squares discriminant analysis (PLS-DA) model built from Luminex dataset separates physiological and IR samples ( n = 25 and 27 devices in total from N = 3 independent experiments, with each point representing the scores on latent variable 1 (LV1) and LV2 from one device. Ellipses show the 95% confidence interval for each condition, with the box plot quantifying the significance of separation between conditions on LV1 by Wilcoxon rank-sum test. The first and third quartiles correspond to the bounds of the box and the median is represented by a bolded line. Box plot whiskers extend 1.5 times the interquartile range. F Loadings on LV1 indicate features contributing to the model, with Gas6 associating with physiological conditions, and several chemokines and cytokines associated with the IR condition. For all plots, * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001.
Gene Exp G6pc Hs00609178 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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gene exp g6pc rn00689876 m1  (Thermo Fisher)
89
Thermo Fisher gene exp g6pc rn00689876 m1
A Insulin clearance diminishes over time in devices cultured in the insulin resistance (“IR”) medium formulation, compared to physiological media. Data are presented as the average of n = 8 devices per media condition across N = 3 experiments, with error bars representing standard deviation and statistical comparison via multiple Mann-Whitney tests with FDR correction. B Gluconeogenesis gene expression ( PCK1, <t>G6PC</t> ) is significantly increased in IR devices relative to physiological control devices, measured via RT-qPCR on Day 12 in culture from n = 4 devices across N = 2 experiments. Changes in genes associated with fatty acid transport and synthesis ( FASN and FABP1 ) are upregulated to a lesser degree. Error bars represent standard deviation from average values. For each gene, a Mann-Whitney test was used to compare between the two media conditions. C Glucose production is increased in IR devices, measured over 24 h from Day 13 to Day 14 of device culture. Data are presented as the average of n = 8 devices per media condition, with error bars representing standard deviation. A Mann-Whitney test was used to compare between the two media conditions. D Row-normalized heatmap of cytokines, chemokines, and growth factors assayed via Luminex from cell culture supernatant collected on Day 10 of device culture across N = 3 experiments. Each row represents one device; n = 25 and 27 total devices for the physiological and IR conditions, respectively. Analyte labels in black indicate significant differences between physiological and IR conditions (P-adj <0.05). E Partial least squares discriminant analysis (PLS-DA) model built from Luminex dataset separates physiological and IR samples ( n = 25 and 27 devices in total from N = 3 independent experiments, with each point representing the scores on latent variable 1 (LV1) and LV2 from one device. Ellipses show the 95% confidence interval for each condition, with the box plot quantifying the significance of separation between conditions on LV1 by Wilcoxon rank-sum test. The first and third quartiles correspond to the bounds of the box and the median is represented by a bolded line. Box plot whiskers extend 1.5 times the interquartile range. F Loadings on LV1 indicate features contributing to the model, with Gas6 associating with physiological conditions, and several chemokines and cytokines associated with the IR condition. For all plots, * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001.
Gene Exp G6pc Rn00689876 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 89/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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china af3419 g6pc rabbit  (Proteintech)
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Proteintech china af3419 g6pc rabbit
A Insulin clearance diminishes over time in devices cultured in the insulin resistance (“IR”) medium formulation, compared to physiological media. Data are presented as the average of n = 8 devices per media condition across N = 3 experiments, with error bars representing standard deviation and statistical comparison via multiple Mann-Whitney tests with FDR correction. B Gluconeogenesis gene expression ( PCK1, <t>G6PC</t> ) is significantly increased in IR devices relative to physiological control devices, measured via RT-qPCR on Day 12 in culture from n = 4 devices across N = 2 experiments. Changes in genes associated with fatty acid transport and synthesis ( FASN and FABP1 ) are upregulated to a lesser degree. Error bars represent standard deviation from average values. For each gene, a Mann-Whitney test was used to compare between the two media conditions. C Glucose production is increased in IR devices, measured over 24 h from Day 13 to Day 14 of device culture. Data are presented as the average of n = 8 devices per media condition, with error bars representing standard deviation. A Mann-Whitney test was used to compare between the two media conditions. D Row-normalized heatmap of cytokines, chemokines, and growth factors assayed via Luminex from cell culture supernatant collected on Day 10 of device culture across N = 3 experiments. Each row represents one device; n = 25 and 27 total devices for the physiological and IR conditions, respectively. Analyte labels in black indicate significant differences between physiological and IR conditions (P-adj <0.05). E Partial least squares discriminant analysis (PLS-DA) model built from Luminex dataset separates physiological and IR samples ( n = 25 and 27 devices in total from N = 3 independent experiments, with each point representing the scores on latent variable 1 (LV1) and LV2 from one device. Ellipses show the 95% confidence interval for each condition, with the box plot quantifying the significance of separation between conditions on LV1 by Wilcoxon rank-sum test. The first and third quartiles correspond to the bounds of the box and the median is represented by a bolded line. Box plot whiskers extend 1.5 times the interquartile range. F Loadings on LV1 indicate features contributing to the model, with Gas6 associating with physiological conditions, and several chemokines and cytokines associated with the IR condition. For all plots, * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001.
China Af3419 G6pc Rabbit, supplied by Proteintech, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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g6pase  (Proteintech)
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Proteintech g6pase
A Insulin clearance diminishes over time in devices cultured in the insulin resistance (“IR”) medium formulation, compared to physiological media. Data are presented as the average of n = 8 devices per media condition across N = 3 experiments, with error bars representing standard deviation and statistical comparison via multiple Mann-Whitney tests with FDR correction. B Gluconeogenesis gene expression ( PCK1, <t>G6PC</t> ) is significantly increased in IR devices relative to physiological control devices, measured via RT-qPCR on Day 12 in culture from n = 4 devices across N = 2 experiments. Changes in genes associated with fatty acid transport and synthesis ( FASN and FABP1 ) are upregulated to a lesser degree. Error bars represent standard deviation from average values. For each gene, a Mann-Whitney test was used to compare between the two media conditions. C Glucose production is increased in IR devices, measured over 24 h from Day 13 to Day 14 of device culture. Data are presented as the average of n = 8 devices per media condition, with error bars representing standard deviation. A Mann-Whitney test was used to compare between the two media conditions. D Row-normalized heatmap of cytokines, chemokines, and growth factors assayed via Luminex from cell culture supernatant collected on Day 10 of device culture across N = 3 experiments. Each row represents one device; n = 25 and 27 total devices for the physiological and IR conditions, respectively. Analyte labels in black indicate significant differences between physiological and IR conditions (P-adj <0.05). E Partial least squares discriminant analysis (PLS-DA) model built from Luminex dataset separates physiological and IR samples ( n = 25 and 27 devices in total from N = 3 independent experiments, with each point representing the scores on latent variable 1 (LV1) and LV2 from one device. Ellipses show the 95% confidence interval for each condition, with the box plot quantifying the significance of separation between conditions on LV1 by Wilcoxon rank-sum test. The first and third quartiles correspond to the bounds of the box and the median is represented by a bolded line. Box plot whiskers extend 1.5 times the interquartile range. F Loadings on LV1 indicate features contributing to the model, with Gas6 associating with physiological conditions, and several chemokines and cytokines associated with the IR condition. For all plots, * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001.
G6pase, supplied by Proteintech, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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glucose 6 phosphatase g6pc  (Proteintech)
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A Insulin clearance diminishes over time in devices cultured in the insulin resistance (“IR”) medium formulation, compared to physiological media. Data are presented as the average of n = 8 devices per media condition across N = 3 experiments, with error bars representing standard deviation and statistical comparison via multiple Mann-Whitney tests with FDR correction. B Gluconeogenesis gene expression ( PCK1, <t>G6PC</t> ) is significantly increased in IR devices relative to physiological control devices, measured via RT-qPCR on Day 12 in culture from n = 4 devices across N = 2 experiments. Changes in genes associated with fatty acid transport and synthesis ( FASN and FABP1 ) are upregulated to a lesser degree. Error bars represent standard deviation from average values. For each gene, a Mann-Whitney test was used to compare between the two media conditions. C Glucose production is increased in IR devices, measured over 24 h from Day 13 to Day 14 of device culture. Data are presented as the average of n = 8 devices per media condition, with error bars representing standard deviation. A Mann-Whitney test was used to compare between the two media conditions. D Row-normalized heatmap of cytokines, chemokines, and growth factors assayed via Luminex from cell culture supernatant collected on Day 10 of device culture across N = 3 experiments. Each row represents one device; n = 25 and 27 total devices for the physiological and IR conditions, respectively. Analyte labels in black indicate significant differences between physiological and IR conditions (P-adj <0.05). E Partial least squares discriminant analysis (PLS-DA) model built from Luminex dataset separates physiological and IR samples ( n = 25 and 27 devices in total from N = 3 independent experiments, with each point representing the scores on latent variable 1 (LV1) and LV2 from one device. Ellipses show the 95% confidence interval for each condition, with the box plot quantifying the significance of separation between conditions on LV1 by Wilcoxon rank-sum test. The first and third quartiles correspond to the bounds of the box and the median is represented by a bolded line. Box plot whiskers extend 1.5 times the interquartile range. F Loadings on LV1 indicate features contributing to the model, with Gas6 associating with physiological conditions, and several chemokines and cytokines associated with the IR condition. For all plots, * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001.
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g6pc monoclonal antibody  (Proteintech)
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A Insulin clearance diminishes over time in devices cultured in the insulin resistance (“IR”) medium formulation, compared to physiological media. Data are presented as the average of n = 8 devices per media condition across N = 3 experiments, with error bars representing standard deviation and statistical comparison via multiple Mann-Whitney tests with FDR correction. B Gluconeogenesis gene expression ( PCK1, <t>G6PC</t> ) is significantly increased in IR devices relative to physiological control devices, measured via RT-qPCR on Day 12 in culture from n = 4 devices across N = 2 experiments. Changes in genes associated with fatty acid transport and synthesis ( FASN and FABP1 ) are upregulated to a lesser degree. Error bars represent standard deviation from average values. For each gene, a Mann-Whitney test was used to compare between the two media conditions. C Glucose production is increased in IR devices, measured over 24 h from Day 13 to Day 14 of device culture. Data are presented as the average of n = 8 devices per media condition, with error bars representing standard deviation. A Mann-Whitney test was used to compare between the two media conditions. D Row-normalized heatmap of cytokines, chemokines, and growth factors assayed via Luminex from cell culture supernatant collected on Day 10 of device culture across N = 3 experiments. Each row represents one device; n = 25 and 27 total devices for the physiological and IR conditions, respectively. Analyte labels in black indicate significant differences between physiological and IR conditions (P-adj <0.05). E Partial least squares discriminant analysis (PLS-DA) model built from Luminex dataset separates physiological and IR samples ( n = 25 and 27 devices in total from N = 3 independent experiments, with each point representing the scores on latent variable 1 (LV1) and LV2 from one device. Ellipses show the 95% confidence interval for each condition, with the box plot quantifying the significance of separation between conditions on LV1 by Wilcoxon rank-sum test. The first and third quartiles correspond to the bounds of the box and the median is represented by a bolded line. Box plot whiskers extend 1.5 times the interquartile range. F Loadings on LV1 indicate features contributing to the model, with Gas6 associating with physiological conditions, and several chemokines and cytokines associated with the IR condition. For all plots, * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001.
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A Insulin clearance diminishes over time in devices cultured in the insulin resistance (“IR”) medium formulation, compared to physiological media. Data are presented as the average of n = 8 devices per media condition across N = 3 experiments, with error bars representing standard deviation and statistical comparison via multiple Mann-Whitney tests with FDR correction. B Gluconeogenesis gene expression ( PCK1, G6PC ) is significantly increased in IR devices relative to physiological control devices, measured via RT-qPCR on Day 12 in culture from n = 4 devices across N = 2 experiments. Changes in genes associated with fatty acid transport and synthesis ( FASN and FABP1 ) are upregulated to a lesser degree. Error bars represent standard deviation from average values. For each gene, a Mann-Whitney test was used to compare between the two media conditions. C Glucose production is increased in IR devices, measured over 24 h from Day 13 to Day 14 of device culture. Data are presented as the average of n = 8 devices per media condition, with error bars representing standard deviation. A Mann-Whitney test was used to compare between the two media conditions. D Row-normalized heatmap of cytokines, chemokines, and growth factors assayed via Luminex from cell culture supernatant collected on Day 10 of device culture across N = 3 experiments. Each row represents one device; n = 25 and 27 total devices for the physiological and IR conditions, respectively. Analyte labels in black indicate significant differences between physiological and IR conditions (P-adj <0.05). E Partial least squares discriminant analysis (PLS-DA) model built from Luminex dataset separates physiological and IR samples ( n = 25 and 27 devices in total from N = 3 independent experiments, with each point representing the scores on latent variable 1 (LV1) and LV2 from one device. Ellipses show the 95% confidence interval for each condition, with the box plot quantifying the significance of separation between conditions on LV1 by Wilcoxon rank-sum test. The first and third quartiles correspond to the bounds of the box and the median is represented by a bolded line. Box plot whiskers extend 1.5 times the interquartile range. F Loadings on LV1 indicate features contributing to the model, with Gas6 associating with physiological conditions, and several chemokines and cytokines associated with the IR condition. For all plots, * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001.

Journal: Nature Communications

Article Title: A vascularized liver microphysiological system captures key features of hepatic insulin resistance and monocyte infiltration

doi: 10.1038/s41467-025-68031-6

Figure Lengend Snippet: A Insulin clearance diminishes over time in devices cultured in the insulin resistance (“IR”) medium formulation, compared to physiological media. Data are presented as the average of n = 8 devices per media condition across N = 3 experiments, with error bars representing standard deviation and statistical comparison via multiple Mann-Whitney tests with FDR correction. B Gluconeogenesis gene expression ( PCK1, G6PC ) is significantly increased in IR devices relative to physiological control devices, measured via RT-qPCR on Day 12 in culture from n = 4 devices across N = 2 experiments. Changes in genes associated with fatty acid transport and synthesis ( FASN and FABP1 ) are upregulated to a lesser degree. Error bars represent standard deviation from average values. For each gene, a Mann-Whitney test was used to compare between the two media conditions. C Glucose production is increased in IR devices, measured over 24 h from Day 13 to Day 14 of device culture. Data are presented as the average of n = 8 devices per media condition, with error bars representing standard deviation. A Mann-Whitney test was used to compare between the two media conditions. D Row-normalized heatmap of cytokines, chemokines, and growth factors assayed via Luminex from cell culture supernatant collected on Day 10 of device culture across N = 3 experiments. Each row represents one device; n = 25 and 27 total devices for the physiological and IR conditions, respectively. Analyte labels in black indicate significant differences between physiological and IR conditions (P-adj <0.05). E Partial least squares discriminant analysis (PLS-DA) model built from Luminex dataset separates physiological and IR samples ( n = 25 and 27 devices in total from N = 3 independent experiments, with each point representing the scores on latent variable 1 (LV1) and LV2 from one device. Ellipses show the 95% confidence interval for each condition, with the box plot quantifying the significance of separation between conditions on LV1 by Wilcoxon rank-sum test. The first and third quartiles correspond to the bounds of the box and the median is represented by a bolded line. Box plot whiskers extend 1.5 times the interquartile range. F Loadings on LV1 indicate features contributing to the model, with Gas6 associating with physiological conditions, and several chemokines and cytokines associated with the IR condition. For all plots, * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001.

Article Snippet: Next, qPCR was performed using TaqMan Fast Advanced Master Mix (Applied Biosystems, 4444557) with probes for PCK1 (Hs00159918_m1), G6PC (Hs00609178_m1), FASN (Hs01005622_m1), FABP1 (Hs00155026_m1), and endogenous control 18S (Hs03928990_g1).

Techniques: Cell Culture, Formulation, Standard Deviation, Comparison, MANN-WHITNEY, Gene Expression, Control, Quantitative RT-PCR, Luminex