Journal: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Article Title: Clinical Validation of a Novel Pressure Microcatheter‐Based Nonhyperemic Pressure Ratio ( SUPREME II Study )

doi: 10.1161/JAHA.125.041920

Figure Lengend Snippet: FFR indicates fractional flow reserve; PCI, percutaneous coronary intervention; PMC, piezoresistive pressure microcatheter; and PW, pressure wire.

Article Snippet: SUPREME II (Sensor‐Equipped Ultrathin Pressure Microcatheter Versus Pressure Wire for Physiological Measurements) was a prospective, observational, multicenter study that evaluated the efficacy of the cRR measured by the PMC (TruePhysio, Insight Lifetech, Shenzhen, China), compared with the FFR and RFR measured by the PW (PressureWire X, Abbott Vascular, St Paul, MN, USA) in diagnosing hemodynamically significant stenosis ( NCT05417763 ).

Techniques:

Journal: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Article Title: Clinical Validation of a Novel Pressure Microcatheter‐Based Nonhyperemic Pressure Ratio ( SUPREME II Study )

doi: 10.1161/JAHA.125.041920

Figure Lengend Snippet: Using FFR ≤0.80 as the reference gold standard, the ROC curves had AUC of 0.914 for cRR ( A ) and 0.888 for RFR ( C ), respectively. The optimal cutoff value to detect FFR ≤0.80 was 0.89 by cRR ( B ) and 0.91 by RFR ( D ), respectively. AUC indicates area under the curve; cRR, constant resistance ratio; FFR, fractional flow reserve; NHPR, nonhyperemic pressure ratio; PMC, piezoresistive pressure microcatheter; PW, pressure wire; RFR, resting full‐cycle ratio; ROC, receiver operating characteristic curve; Sens, sensitivity; and Spec, specificity.

Article Snippet: SUPREME II (Sensor‐Equipped Ultrathin Pressure Microcatheter Versus Pressure Wire for Physiological Measurements) was a prospective, observational, multicenter study that evaluated the efficacy of the cRR measured by the PMC (TruePhysio, Insight Lifetech, Shenzhen, China), compared with the FFR and RFR measured by the PW (PressureWire X, Abbott Vascular, St Paul, MN, USA) in diagnosing hemodynamically significant stenosis ( NCT05417763 ).

Techniques:

Journal: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Article Title: Clinical Validation of a Novel Pressure Microcatheter‐Based Nonhyperemic Pressure Ratio ( SUPREME II Study )

doi: 10.1161/JAHA.125.041920

Figure Lengend Snippet: AUC indicates area under the curve; cRR, constant resistance ratio; FFR, fractional flow reserve; PMC, piezoresistive pressure microcatheter; PW, pressure wire; and RFR, resting full‐cycle ratio.

Article Snippet: SUPREME II (Sensor‐Equipped Ultrathin Pressure Microcatheter Versus Pressure Wire for Physiological Measurements) was a prospective, observational, multicenter study that evaluated the efficacy of the cRR measured by the PMC (TruePhysio, Insight Lifetech, Shenzhen, China), compared with the FFR and RFR measured by the PW (PressureWire X, Abbott Vascular, St Paul, MN, USA) in diagnosing hemodynamically significant stenosis ( NCT05417763 ).

Techniques:

Journal: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Article Title: Clinical Validation of a Novel Pressure Microcatheter‐Based Nonhyperemic Pressure Ratio ( SUPREME II Study )

doi: 10.1161/JAHA.125.041920

Figure Lengend Snippet: A , The proportions of vasodilators‐free patients in cRR–FFR or RFR–FFR strategies. Sensitive analysis according to different definitions of FFR gray zone are summarized in Table . B , Diagnostic performance of cRR–FFR strategy compared with RFR–FFR strategy out of FFR gray zone. cRR indicates constant resistance ratio; DA, diagnostic accuracy; FFR, fractional flow reserve; NHPR, nonhyperemic pressure ratio; NPV, negative predictive value; PMC, piezoresistive pressure microcatheter; PPV, positive predictive value; PW, pressure wire; RFR, resting full‐cycle ratio; SEN, sensitivity; and SPE, specificity.

Article Snippet: SUPREME II (Sensor‐Equipped Ultrathin Pressure Microcatheter Versus Pressure Wire for Physiological Measurements) was a prospective, observational, multicenter study that evaluated the efficacy of the cRR measured by the PMC (TruePhysio, Insight Lifetech, Shenzhen, China), compared with the FFR and RFR measured by the PW (PressureWire X, Abbott Vascular, St Paul, MN, USA) in diagnosing hemodynamically significant stenosis ( NCT05417763 ).

Techniques: Diagnostic Assay

Journal: BMC Medical Imaging

Article Title: Incremental prognostic value of pericoronary fat attenuation index in diabetic patients with non-obstructive coronary artery disease

doi: 10.1186/s12880-025-02146-6

Figure Lengend Snippet: Flowchart of study design. DM, diabetes mellitus; CCTA, coronary computed tomography angiography; CAD, coronary artery disease; CT-FFR, CCTA-derived fractional flow reserve; FAI, fat attenuation index; MACE, major adverse cardiovascular events

Article Snippet: CT-FFR analysis was performed using a machine learning-based CT-FFR software (version 3.5, Siemens Healthineers, Germany).

Techniques: Computed Tomography, Derivative Assay

Journal: BMC Medical Imaging

Article Title: Incremental prognostic value of pericoronary fat attenuation index in diabetic patients with non-obstructive coronary artery disease

doi: 10.1186/s12880-025-02146-6

Figure Lengend Snippet: Kaplan–Meier curves for cumulative MACE rates ( A , B , C ) and cumulative MACCE rates ( D , E , F ) for stratified groups based on HRP, CT-FFR, and pericoronary FAI. MACE, major adverse cardiovascular events; MACCE, major adverse cardiovascular and cerebrovascular events; HRP, high-risk plaque; CT-FFR, CCTA-derived fractional flow reserve; FAI, fat attenuation index; HU, Hounsfield units

Article Snippet: CT-FFR analysis was performed using a machine learning-based CT-FFR software (version 3.5, Siemens Healthineers, Germany).

Techniques: Derivative Assay

Journal: BMC Medical Imaging

Article Title: Incremental prognostic value of pericoronary fat attenuation index in diabetic patients with non-obstructive coronary artery disease

doi: 10.1186/s12880-025-02146-6

Figure Lengend Snippet: ROC curves of all models in predicting MACE ( A ) and MACCE ( B ). Model 1: HRP; Model 2: CT-FFR; Model 3: pericoronary FAI; Model 4: HRP + CT-FFR; Model 5: Model 4 + pericoronary FAI. ROC, receiver operating characteristic; MACE, major adverse cardiovascular events; MACCE, major adverse cardiovascular and cerebrovascular events; HRP, high-risk plaque; CT-FFR, CCTA-derived fractional flow reserve; FAI, fat attenuation index; AUC, area under the curve; CI, confidence interval

Article Snippet: CT-FFR analysis was performed using a machine learning-based CT-FFR software (version 3.5, Siemens Healthineers, Germany).

Techniques: Derivative Assay

Journal: BMC Medical Imaging

Article Title: Incremental prognostic value of pericoronary fat attenuation index in diabetic patients with non-obstructive coronary artery disease

doi: 10.1186/s12880-025-02146-6

Figure Lengend Snippet: A representative case of DM patients with non-obstructive CAD. CCTA showed CAD-RADS 2, with 25–49% stenosis in LAD as well as 1–24% stenosis in RCA, and there was a HRP characterized by low attenuation plaque and spotty calcification in LAD; CT-FFR was 0.88; pericoronary FAI was − 60.97 HU. This patient underwent acute non-ST-segment elevation myocardial infarction 40 months after CCTA. DM, diabetes mellitus; CAD, coronary artery disease; CCTA, coronary computed tomography angiography; CAD-RADS, Coronary Artery Disease-Reporting and Data System; LAD, left anterior descending; LCX, left circumflex; RCA, right coronary artery; HRP, high-risk plaque; CT-FFR, CCTA-derived fractional flow reserve; FAI, fat attenuation index; HU, Hounsfield units

Article Snippet: CT-FFR analysis was performed using a machine learning-based CT-FFR software (version 3.5, Siemens Healthineers, Germany).

Techniques: Computed Tomography, Derivative Assay