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u0126 etoh  (MedChemExpress)
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MedChemExpress u0126 etoh
Identification of the mechanism underlying IU1-mediated reprogramming of M2 macrophages (A and B) Verification of the efficiency of i.v. injection of clodronate liposome (Clo) in depleting TAMs of the blood (A) and the TME (B). (C and D) Statistics of tumor size monitored for 21 days in MC38 tumor-bearing mice after various indicated treatments. (E) Statistic of the percentage of CTLs in the TME after the indicated treatment. (F) Volcano plots of the differentially expressed genes between the PBS and the IU1 group. Red dots show significantly up-regulated genes in the IU1 group, and green dots show significantly down-regulated genes. (G) Heatmap illustrates the differentially expressed M1-and M2-related genes in TAMs in the IU1 group and the PBS group based on RNA sequencing results. (H) KEGG analysis identifies the 17 most enriched pathways based on the differentially expressed genes of the two groups. (I) Western blotting of p -JNK, p -ERK, p-p38, and GAPDH in IL-4/13-BMDM M2 cells treated with IU1 at the indicated time points. (J) RT-PCR to verify the typical M1/M2 polarization-related genes in M2 macrophages after treatment with IU1. (K) Flow cytometry analysis of CD206 expression on the IL-4/13-induced BMDM M2 cells from various indicated treatments. Treatments indicated: DMSO stimulation, IU1 (10 μM) stimulation, IU1 (10 μM) stimulation in the presence of inhibitors of p38 (SB203580, 10 μM), JNK (SP600125, 10 μM), Erk1/2 <t>(U0126-EtOH,</t> 10 μM). Statistical analysis was performed using one-way ANOVA with Tukey’s multiple comparison test. Data are presented as the mean ± SEM. ∗ p < 0.05, ∗∗ p < 0.01, and ∗∗∗ p < 0.001, and ns: not significant.
U0126 Etoh, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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absolute ethanol etoh  (Fisher Scientific)
86
Fisher Scientific absolute ethanol etoh
Identification of the mechanism underlying IU1-mediated reprogramming of M2 macrophages (A and B) Verification of the efficiency of i.v. injection of clodronate liposome (Clo) in depleting TAMs of the blood (A) and the TME (B). (C and D) Statistics of tumor size monitored for 21 days in MC38 tumor-bearing mice after various indicated treatments. (E) Statistic of the percentage of CTLs in the TME after the indicated treatment. (F) Volcano plots of the differentially expressed genes between the PBS and the IU1 group. Red dots show significantly up-regulated genes in the IU1 group, and green dots show significantly down-regulated genes. (G) Heatmap illustrates the differentially expressed M1-and M2-related genes in TAMs in the IU1 group and the PBS group based on RNA sequencing results. (H) KEGG analysis identifies the 17 most enriched pathways based on the differentially expressed genes of the two groups. (I) Western blotting of p -JNK, p -ERK, p-p38, and GAPDH in IL-4/13-BMDM M2 cells treated with IU1 at the indicated time points. (J) RT-PCR to verify the typical M1/M2 polarization-related genes in M2 macrophages after treatment with IU1. (K) Flow cytometry analysis of CD206 expression on the IL-4/13-induced BMDM M2 cells from various indicated treatments. Treatments indicated: DMSO stimulation, IU1 (10 μM) stimulation, IU1 (10 μM) stimulation in the presence of inhibitors of p38 (SB203580, 10 μM), JNK (SP600125, 10 μM), Erk1/2 <t>(U0126-EtOH,</t> 10 μM). Statistical analysis was performed using one-way ANOVA with Tukey’s multiple comparison test. Data are presented as the mean ± SEM. ∗ p < 0.05, ∗∗ p < 0.01, and ∗∗∗ p < 0.001, and ns: not significant.
Absolute Ethanol Etoh, supplied by Fisher Scientific, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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absolute ethanol etoh - by Bioz Stars, 2026-07
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etoh molecules  (Personna Medical)
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Personna Medical etoh molecules
Identification of the mechanism underlying IU1-mediated reprogramming of M2 macrophages (A and B) Verification of the efficiency of i.v. injection of clodronate liposome (Clo) in depleting TAMs of the blood (A) and the TME (B). (C and D) Statistics of tumor size monitored for 21 days in MC38 tumor-bearing mice after various indicated treatments. (E) Statistic of the percentage of CTLs in the TME after the indicated treatment. (F) Volcano plots of the differentially expressed genes between the PBS and the IU1 group. Red dots show significantly up-regulated genes in the IU1 group, and green dots show significantly down-regulated genes. (G) Heatmap illustrates the differentially expressed M1-and M2-related genes in TAMs in the IU1 group and the PBS group based on RNA sequencing results. (H) KEGG analysis identifies the 17 most enriched pathways based on the differentially expressed genes of the two groups. (I) Western blotting of p -JNK, p -ERK, p-p38, and GAPDH in IL-4/13-BMDM M2 cells treated with IU1 at the indicated time points. (J) RT-PCR to verify the typical M1/M2 polarization-related genes in M2 macrophages after treatment with IU1. (K) Flow cytometry analysis of CD206 expression on the IL-4/13-induced BMDM M2 cells from various indicated treatments. Treatments indicated: DMSO stimulation, IU1 (10 μM) stimulation, IU1 (10 μM) stimulation in the presence of inhibitors of p38 (SB203580, 10 μM), JNK (SP600125, 10 μM), Erk1/2 <t>(U0126-EtOH,</t> 10 μM). Statistical analysis was performed using one-way ANOVA with Tukey’s multiple comparison test. Data are presented as the mean ± SEM. ∗ p < 0.05, ∗∗ p < 0.01, and ∗∗∗ p < 0.001, and ns: not significant.
Etoh Molecules, supplied by Personna Medical, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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etoh molecules - by Bioz Stars, 2026-07
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etoh  (Fisher Scientific)
86
Fisher Scientific etoh
Identification of the mechanism underlying IU1-mediated reprogramming of M2 macrophages (A and B) Verification of the efficiency of i.v. injection of clodronate liposome (Clo) in depleting TAMs of the blood (A) and the TME (B). (C and D) Statistics of tumor size monitored for 21 days in MC38 tumor-bearing mice after various indicated treatments. (E) Statistic of the percentage of CTLs in the TME after the indicated treatment. (F) Volcano plots of the differentially expressed genes between the PBS and the IU1 group. Red dots show significantly up-regulated genes in the IU1 group, and green dots show significantly down-regulated genes. (G) Heatmap illustrates the differentially expressed M1-and M2-related genes in TAMs in the IU1 group and the PBS group based on RNA sequencing results. (H) KEGG analysis identifies the 17 most enriched pathways based on the differentially expressed genes of the two groups. (I) Western blotting of p -JNK, p -ERK, p-p38, and GAPDH in IL-4/13-BMDM M2 cells treated with IU1 at the indicated time points. (J) RT-PCR to verify the typical M1/M2 polarization-related genes in M2 macrophages after treatment with IU1. (K) Flow cytometry analysis of CD206 expression on the IL-4/13-induced BMDM M2 cells from various indicated treatments. Treatments indicated: DMSO stimulation, IU1 (10 μM) stimulation, IU1 (10 μM) stimulation in the presence of inhibitors of p38 (SB203580, 10 μM), JNK (SP600125, 10 μM), Erk1/2 <t>(U0126-EtOH,</t> 10 μM). Statistical analysis was performed using one-way ANOVA with Tukey’s multiple comparison test. Data are presented as the mean ± SEM. ∗ p < 0.05, ∗∗ p < 0.01, and ∗∗∗ p < 0.001, and ns: not significant.
Etoh, supplied by Fisher Scientific, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/etoh/pm42322017-128-36-37?v=Fisher+Scientific
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etoh h2o uplc dad alltech alltima c  (Alltech Inc)
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Alltech Inc etoh h2o uplc dad alltech alltima c
Identification of the mechanism underlying IU1-mediated reprogramming of M2 macrophages (A and B) Verification of the efficiency of i.v. injection of clodronate liposome (Clo) in depleting TAMs of the blood (A) and the TME (B). (C and D) Statistics of tumor size monitored for 21 days in MC38 tumor-bearing mice after various indicated treatments. (E) Statistic of the percentage of CTLs in the TME after the indicated treatment. (F) Volcano plots of the differentially expressed genes between the PBS and the IU1 group. Red dots show significantly up-regulated genes in the IU1 group, and green dots show significantly down-regulated genes. (G) Heatmap illustrates the differentially expressed M1-and M2-related genes in TAMs in the IU1 group and the PBS group based on RNA sequencing results. (H) KEGG analysis identifies the 17 most enriched pathways based on the differentially expressed genes of the two groups. (I) Western blotting of p -JNK, p -ERK, p-p38, and GAPDH in IL-4/13-BMDM M2 cells treated with IU1 at the indicated time points. (J) RT-PCR to verify the typical M1/M2 polarization-related genes in M2 macrophages after treatment with IU1. (K) Flow cytometry analysis of CD206 expression on the IL-4/13-induced BMDM M2 cells from various indicated treatments. Treatments indicated: DMSO stimulation, IU1 (10 μM) stimulation, IU1 (10 μM) stimulation in the presence of inhibitors of p38 (SB203580, 10 μM), JNK (SP600125, 10 μM), Erk1/2 <t>(U0126-EtOH,</t> 10 μM). Statistical analysis was performed using one-way ANOVA with Tukey’s multiple comparison test. Data are presented as the mean ± SEM. ∗ p < 0.05, ∗∗ p < 0.01, and ∗∗∗ p < 0.001, and ns: not significant.
Etoh H2o Uplc Dad Alltech Alltima C, supplied by Alltech Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/etoh/pm42280193-359-209-211?v=Alltech+Inc
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etoh h2o uplc dad alltech alltima c - by Bioz Stars, 2026-07
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ethanol etoh  (Fisher Scientific)
86
Fisher Scientific ethanol etoh
Identification of the mechanism underlying IU1-mediated reprogramming of M2 macrophages (A and B) Verification of the efficiency of i.v. injection of clodronate liposome (Clo) in depleting TAMs of the blood (A) and the TME (B). (C and D) Statistics of tumor size monitored for 21 days in MC38 tumor-bearing mice after various indicated treatments. (E) Statistic of the percentage of CTLs in the TME after the indicated treatment. (F) Volcano plots of the differentially expressed genes between the PBS and the IU1 group. Red dots show significantly up-regulated genes in the IU1 group, and green dots show significantly down-regulated genes. (G) Heatmap illustrates the differentially expressed M1-and M2-related genes in TAMs in the IU1 group and the PBS group based on RNA sequencing results. (H) KEGG analysis identifies the 17 most enriched pathways based on the differentially expressed genes of the two groups. (I) Western blotting of p -JNK, p -ERK, p-p38, and GAPDH in IL-4/13-BMDM M2 cells treated with IU1 at the indicated time points. (J) RT-PCR to verify the typical M1/M2 polarization-related genes in M2 macrophages after treatment with IU1. (K) Flow cytometry analysis of CD206 expression on the IL-4/13-induced BMDM M2 cells from various indicated treatments. Treatments indicated: DMSO stimulation, IU1 (10 μM) stimulation, IU1 (10 μM) stimulation in the presence of inhibitors of p38 (SB203580, 10 μM), JNK (SP600125, 10 μM), Erk1/2 <t>(U0126-EtOH,</t> 10 μM). Statistical analysis was performed using one-way ANOVA with Tukey’s multiple comparison test. Data are presented as the mean ± SEM. ∗ p < 0.05, ∗∗ p < 0.01, and ∗∗∗ p < 0.001, and ns: not significant.
Ethanol Etoh, supplied by Fisher Scientific, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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anhydrous ethanol etoh  (Servicebio Inc)
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Servicebio Inc anhydrous ethanol etoh
Identification of the mechanism underlying IU1-mediated reprogramming of M2 macrophages (A and B) Verification of the efficiency of i.v. injection of clodronate liposome (Clo) in depleting TAMs of the blood (A) and the TME (B). (C and D) Statistics of tumor size monitored for 21 days in MC38 tumor-bearing mice after various indicated treatments. (E) Statistic of the percentage of CTLs in the TME after the indicated treatment. (F) Volcano plots of the differentially expressed genes between the PBS and the IU1 group. Red dots show significantly up-regulated genes in the IU1 group, and green dots show significantly down-regulated genes. (G) Heatmap illustrates the differentially expressed M1-and M2-related genes in TAMs in the IU1 group and the PBS group based on RNA sequencing results. (H) KEGG analysis identifies the 17 most enriched pathways based on the differentially expressed genes of the two groups. (I) Western blotting of p -JNK, p -ERK, p-p38, and GAPDH in IL-4/13-BMDM M2 cells treated with IU1 at the indicated time points. (J) RT-PCR to verify the typical M1/M2 polarization-related genes in M2 macrophages after treatment with IU1. (K) Flow cytometry analysis of CD206 expression on the IL-4/13-induced BMDM M2 cells from various indicated treatments. Treatments indicated: DMSO stimulation, IU1 (10 μM) stimulation, IU1 (10 μM) stimulation in the presence of inhibitors of p38 (SB203580, 10 μM), JNK (SP600125, 10 μM), Erk1/2 <t>(U0126-EtOH,</t> 10 μM). Statistical analysis was performed using one-way ANOVA with Tukey’s multiple comparison test. Data are presented as the mean ± SEM. ∗ p < 0.05, ∗∗ p < 0.01, and ∗∗∗ p < 0.001, and ns: not significant.
Anhydrous Ethanol Etoh, supplied by Servicebio Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ethanol anhydrous etoh  (Shanghai Macklin Biochemical)
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Shanghai Macklin Biochemical ethanol anhydrous etoh
Identification of the mechanism underlying IU1-mediated reprogramming of M2 macrophages (A and B) Verification of the efficiency of i.v. injection of clodronate liposome (Clo) in depleting TAMs of the blood (A) and the TME (B). (C and D) Statistics of tumor size monitored for 21 days in MC38 tumor-bearing mice after various indicated treatments. (E) Statistic of the percentage of CTLs in the TME after the indicated treatment. (F) Volcano plots of the differentially expressed genes between the PBS and the IU1 group. Red dots show significantly up-regulated genes in the IU1 group, and green dots show significantly down-regulated genes. (G) Heatmap illustrates the differentially expressed M1-and M2-related genes in TAMs in the IU1 group and the PBS group based on RNA sequencing results. (H) KEGG analysis identifies the 17 most enriched pathways based on the differentially expressed genes of the two groups. (I) Western blotting of p -JNK, p -ERK, p-p38, and GAPDH in IL-4/13-BMDM M2 cells treated with IU1 at the indicated time points. (J) RT-PCR to verify the typical M1/M2 polarization-related genes in M2 macrophages after treatment with IU1. (K) Flow cytometry analysis of CD206 expression on the IL-4/13-induced BMDM M2 cells from various indicated treatments. Treatments indicated: DMSO stimulation, IU1 (10 μM) stimulation, IU1 (10 μM) stimulation in the presence of inhibitors of p38 (SB203580, 10 μM), JNK (SP600125, 10 μM), Erk1/2 <t>(U0126-EtOH,</t> 10 μM). Statistical analysis was performed using one-way ANOVA with Tukey’s multiple comparison test. Data are presented as the mean ± SEM. ∗ p < 0.05, ∗∗ p < 0.01, and ∗∗∗ p < 0.001, and ns: not significant.
Ethanol Anhydrous Etoh, supplied by Shanghai Macklin Biochemical, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Identification of the mechanism underlying IU1-mediated reprogramming of M2 macrophages (A and B) Verification of the efficiency of i.v. injection of clodronate liposome (Clo) in depleting TAMs of the blood (A) and the TME (B). (C and D) Statistics of tumor size monitored for 21 days in MC38 tumor-bearing mice after various indicated treatments. (E) Statistic of the percentage of CTLs in the TME after the indicated treatment. (F) Volcano plots of the differentially expressed genes between the PBS and the IU1 group. Red dots show significantly up-regulated genes in the IU1 group, and green dots show significantly down-regulated genes. (G) Heatmap illustrates the differentially expressed M1-and M2-related genes in TAMs in the IU1 group and the PBS group based on RNA sequencing results. (H) KEGG analysis identifies the 17 most enriched pathways based on the differentially expressed genes of the two groups. (I) Western blotting of p -JNK, p -ERK, p-p38, and GAPDH in IL-4/13-BMDM M2 cells treated with IU1 at the indicated time points. (J) RT-PCR to verify the typical M1/M2 polarization-related genes in M2 macrophages after treatment with IU1. (K) Flow cytometry analysis of CD206 expression on the IL-4/13-induced BMDM M2 cells from various indicated treatments. Treatments indicated: DMSO stimulation, IU1 (10 μM) stimulation, IU1 (10 μM) stimulation in the presence of inhibitors of p38 (SB203580, 10 μM), JNK (SP600125, 10 μM), Erk1/2 (U0126-EtOH, 10 μM). Statistical analysis was performed using one-way ANOVA with Tukey’s multiple comparison test. Data are presented as the mean ± SEM. ∗ p < 0.05, ∗∗ p < 0.01, and ∗∗∗ p < 0.001, and ns: not significant.

Journal: iScience

Article Title: Targeting USP14 enhances immunotherapy response by reprogramming tumor-associated macrophages in colon cancer

doi: 10.1016/j.isci.2026.115362

Figure Lengend Snippet: Identification of the mechanism underlying IU1-mediated reprogramming of M2 macrophages (A and B) Verification of the efficiency of i.v. injection of clodronate liposome (Clo) in depleting TAMs of the blood (A) and the TME (B). (C and D) Statistics of tumor size monitored for 21 days in MC38 tumor-bearing mice after various indicated treatments. (E) Statistic of the percentage of CTLs in the TME after the indicated treatment. (F) Volcano plots of the differentially expressed genes between the PBS and the IU1 group. Red dots show significantly up-regulated genes in the IU1 group, and green dots show significantly down-regulated genes. (G) Heatmap illustrates the differentially expressed M1-and M2-related genes in TAMs in the IU1 group and the PBS group based on RNA sequencing results. (H) KEGG analysis identifies the 17 most enriched pathways based on the differentially expressed genes of the two groups. (I) Western blotting of p -JNK, p -ERK, p-p38, and GAPDH in IL-4/13-BMDM M2 cells treated with IU1 at the indicated time points. (J) RT-PCR to verify the typical M1/M2 polarization-related genes in M2 macrophages after treatment with IU1. (K) Flow cytometry analysis of CD206 expression on the IL-4/13-induced BMDM M2 cells from various indicated treatments. Treatments indicated: DMSO stimulation, IU1 (10 μM) stimulation, IU1 (10 μM) stimulation in the presence of inhibitors of p38 (SB203580, 10 μM), JNK (SP600125, 10 μM), Erk1/2 (U0126-EtOH, 10 μM). Statistical analysis was performed using one-way ANOVA with Tukey’s multiple comparison test. Data are presented as the mean ± SEM. ∗ p < 0.05, ∗∗ p < 0.01, and ∗∗∗ p < 0.001, and ns: not significant.

Article Snippet: U0126-EtOH , MedChemExpress , HY-12031.

Techniques: Injection, RNA Sequencing, Western Blot, Reverse Transcription Polymerase Chain Reaction, Flow Cytometry, Expressing, Comparison