Journal: Discover Oncology

Article Title: Integrated network toxicology and immune profiling identify ESR1 as a potential hub linking Benzo[a]pyrene exposure to gastric cancer risk

doi: 10.1007/s12672-026-04939-9

Figure Lengend Snippet: BaP-Target-GC Regulatory Network. Molecular interaction relationships mediated by core targets ESR1/INS/CDK2

Article Snippet: C Differences in immune cell abundance between ESR1 high/low expression groups Fig. 9 Subcellular Localization Patterns of ESR1 in Representative Cell Lines (Data from the Human Protein Atlas).

Techniques:

Journal: Discover Oncology

Article Title: Integrated network toxicology and immune profiling identify ESR1 as a potential hub linking Benzo[a]pyrene exposure to gastric cancer risk

doi: 10.1007/s12672-026-04939-9

Figure Lengend Snippet: PPI Network and Core Target Screening. A ESR1 hub network (Degree = 17) B Target centrality ranking (ESR1 ranked first)

Article Snippet: C Differences in immune cell abundance between ESR1 high/low expression groups Fig. 9 Subcellular Localization Patterns of ESR1 in Representative Cell Lines (Data from the Human Protein Atlas).

Techniques:

Journal: Discover Oncology

Article Title: Integrated network toxicology and immune profiling identify ESR1 as a potential hub linking Benzo[a]pyrene exposure to gastric cancer risk

doi: 10.1007/s12672-026-04939-9

Figure Lengend Snippet: ESR1 Expression Difference and Prognostic Value. A ESR1 expression level in STAD tissues was significantly lower than in normal tissues (Tumor group: 0.55 ± 0.45; Normal group: 0.69 ± 0.37; P = 4.3 e−3 ). B The high ESR1 expression group had significantly longer overall survival (HR = 0.81, 95% CI: 0.66–0.99, P = 0.036)

Article Snippet: C Differences in immune cell abundance between ESR1 high/low expression groups Fig. 9 Subcellular Localization Patterns of ESR1 in Representative Cell Lines (Data from the Human Protein Atlas).

Techniques: Expressing

Journal: Discover Oncology

Article Title: Integrated network toxicology and immune profiling identify ESR1 as a potential hub linking Benzo[a]pyrene exposure to gastric cancer risk

doi: 10.1007/s12672-026-04939-9

Figure Lengend Snippet: Correlation Between ESR1 Expression and Immune Infiltration. A , B Positively correlated immune cells: T cells, B cells, DC, Tem, Cytotoxic cells, TFH. C Differences in immune cell abundance between ESR1 high/low expression groups

Article Snippet: C Differences in immune cell abundance between ESR1 high/low expression groups Fig. 9 Subcellular Localization Patterns of ESR1 in Representative Cell Lines (Data from the Human Protein Atlas).

Techniques: Expressing

Journal: Discover Oncology

Article Title: Integrated network toxicology and immune profiling identify ESR1 as a potential hub linking Benzo[a]pyrene exposure to gastric cancer risk

doi: 10.1007/s12672-026-04939-9

Figure Lengend Snippet: Subcellular Localization Patterns of ESR1 in Representative Cell Lines (Data from the Human Protein Atlas). A MCF-7: Nucleoplasm and Vesicles (78.9 nTPM). B RT-4: Vesicles (3.1 nTPM). C U2OS: Vesicles (0.1 nTPM)

Article Snippet: C Differences in immune cell abundance between ESR1 high/low expression groups Fig. 9 Subcellular Localization Patterns of ESR1 in Representative Cell Lines (Data from the Human Protein Atlas).

Techniques:

Journal: Discover Oncology

Article Title: Integrated network toxicology and immune profiling identify ESR1 as a potential hub linking Benzo[a]pyrene exposure to gastric cancer risk

doi: 10.1007/s12672-026-04939-9

Figure Lengend Snippet: STAD Mutation Landscape Analysis. Top 15 mutated genes associated with ESR1 expression

Article Snippet: C Differences in immune cell abundance between ESR1 high/low expression groups Fig. 9 Subcellular Localization Patterns of ESR1 in Representative Cell Lines (Data from the Human Protein Atlas).

Techniques: Mutagenesis, Expressing

Journal: Discover Oncology

Article Title: Integrated network toxicology and immune profiling identify ESR1 as a potential hub linking Benzo[a]pyrene exposure to gastric cancer risk

doi: 10.1007/s12672-026-04939-9

Figure Lengend Snippet: Molecular Docking Validation of BaP and ESR1. A , B Binding mode diagram (Vina score=-11.2 kcal/mol, strong binding activity)

Article Snippet: C Differences in immune cell abundance between ESR1 high/low expression groups Fig. 9 Subcellular Localization Patterns of ESR1 in Representative Cell Lines (Data from the Human Protein Atlas).

Techniques: Biomarker Discovery, Binding Assay, Activity Assay