Journal: Drug Design, Development and Therapy

Article Title: A Health Technology Assessment Based on Chinese Guideline: Active Vitamin D and Its Analogs in the Treatment of Osteoporosis

doi: 10.2147/DDDT.S465960

Figure Lengend Snippet: Drugs Included in the Evaluation

Article Snippet: Eldecalcitol soft capsules belong to Chugai Group, which is in the 35th position of the world sales ranking in 2022 scored 0.4 points.

Techniques: Capsules, Injection

Journal: Drug Design, Development and Therapy

Article Title: A Health Technology Assessment Based on Chinese Guideline: Active Vitamin D and Its Analogs in the Treatment of Osteoporosis

doi: 10.2147/DDDT.S465960

Figure Lengend Snippet: Pharmaceutical Properties Score Results

Article Snippet: Eldecalcitol soft capsules belong to Chugai Group, which is in the 35th position of the world sales ranking in 2022 scored 0.4 points.

Techniques: Capsules, Injection, In Vivo

Journal: Drug Design, Development and Therapy

Article Title: A Health Technology Assessment Based on Chinese Guideline: Active Vitamin D and Its Analogs in the Treatment of Osteoporosis

doi: 10.2147/DDDT.S465960

Figure Lengend Snippet: Recommendations from National and International Guidelines/Consensus

Article Snippet: Eldecalcitol soft capsules belong to Chugai Group, which is in the 35th position of the world sales ranking in 2022 scored 0.4 points.

Techniques: Biomarker Discovery, Filtration, Analogues

Journal: Drug Design, Development and Therapy

Article Title: A Health Technology Assessment Based on Chinese Guideline: Active Vitamin D and Its Analogs in the Treatment of Osteoporosis

doi: 10.2147/DDDT.S465960

Figure Lengend Snippet: Efficacy Score Results

Article Snippet: Eldecalcitol soft capsules belong to Chugai Group, which is in the 35th position of the world sales ranking in 2022 scored 0.4 points.

Techniques: Capsules, Injection, Biomarker Discovery

Journal: Drug Design, Development and Therapy

Article Title: A Health Technology Assessment Based on Chinese Guideline: Active Vitamin D and Its Analogs in the Treatment of Osteoporosis

doi: 10.2147/DDDT.S465960

Figure Lengend Snippet: Safety Score Results

Article Snippet: Eldecalcitol soft capsules belong to Chugai Group, which is in the 35th position of the world sales ranking in 2022 scored 0.4 points.

Techniques: Capsules, Injection

Journal: Drug Design, Development and Therapy

Article Title: A Health Technology Assessment Based on Chinese Guideline: Active Vitamin D and Its Analogs in the Treatment of Osteoporosis

doi: 10.2147/DDDT.S465960

Figure Lengend Snippet: Basic Economy Information

Article Snippet: Eldecalcitol soft capsules belong to Chugai Group, which is in the 35th position of the world sales ranking in 2022 scored 0.4 points.

Techniques: Capsules, Injection

Journal: Drug Design, Development and Therapy

Article Title: A Health Technology Assessment Based on Chinese Guideline: Active Vitamin D and Its Analogs in the Treatment of Osteoporosis

doi: 10.2147/DDDT.S465960

Figure Lengend Snippet: Economy Score Results

Article Snippet: Eldecalcitol soft capsules belong to Chugai Group, which is in the 35th position of the world sales ranking in 2022 scored 0.4 points.

Techniques: Capsules, Injection

Journal: Drug Design, Development and Therapy

Article Title: A Health Technology Assessment Based on Chinese Guideline: Active Vitamin D and Its Analogs in the Treatment of Osteoporosis

doi: 10.2147/DDDT.S465960

Figure Lengend Snippet: Other Attribute Score Results

Article Snippet: Eldecalcitol soft capsules belong to Chugai Group, which is in the 35th position of the world sales ranking in 2022 scored 0.4 points.

Techniques: Capsules, Injection

Journal: Drug Design, Development and Therapy

Article Title: A Health Technology Assessment Based on Chinese Guideline: Active Vitamin D and Its Analogs in the Treatment of Osteoporosis

doi: 10.2147/DDDT.S465960

Figure Lengend Snippet: Final Total Score Results

Article Snippet: Eldecalcitol soft capsules belong to Chugai Group, which is in the 35th position of the world sales ranking in 2022 scored 0.4 points.

Techniques: Capsules, Injection

Journal: Bone Reports

Article Title: Effects of risedronate, alendronate, and minodronate alone or in combination with eldecalcitol on bone mineral density, quality, and strength in ovariectomized rats

doi: 10.1016/j.bonr.2021.101061

Figure Lengend Snippet: Effect of bisphosphonates, eldecalcitol, and their combinations on the L4 and femoral BMD determined by micro-CT. Lumber vertebral bones (L4) and left femurs were harvested from sham and OVX rats after 16 weeks. (A) Trabecular bone of L4, (B) cortical bone of L4, (C) femoral trabecular bone, and (D) femoral cortical bone. Data are presented as mean + SD. n = 9. ⁎⁎ p < 0.01 and ⁎⁎⁎ p < 0.001 compared with the sham group. b p < 0.01 and c p < 0.001 compared with the vehicle group. † p < 0.05 and †††† p < 0.0001 compared with RIS. ‡ p < 0.05, ‡‡ p < 0.01, and ‡‡‡‡ p < 0.0001 compared with ALN. # p < 0.05, ## p < 0.01, and #### p < 0.0001 compared with MIN. $ p < 0.05, $$ p < 0.01, $$$ p < 0.001, and $$$$ p < 0.0001 compared with ELD. Abbreviations: BMD, bone mineral density; ALN, alendronate; ELD, eldecalcitol; micro-CT, micro-computed tomography; MIN, minodronate; RIS, risedronate.

Article Snippet: ALN, MIN, and ELD were purchased from Wako Pure Chemical Industries (Tokyo, Japan), Chengdu-D-Innovation pharmaceutical (Chengdu, China), and Chugai Pharmaceutical (eldecalcitol capsule, Tokyo, Japan), respectively.

Techniques: Micro-CT

Journal: Bone Reports

Article Title: Effects of risedronate, alendronate, and minodronate alone or in combination with eldecalcitol on bone mineral density, quality, and strength in ovariectomized rats

doi: 10.1016/j.bonr.2021.101061

Figure Lengend Snippet: Effect of bisphosphonates, eldecalcitol, and their combinations on the L4 bone strength in OVX rats. Lumber vertebral bones (L4) were harvested from sham and OVX rats after 16 weeks. (A) Maximum load and (B) stiffness. Data are presented as mean + SD. n = 9. ⁎ p < 0.05 compared with the sham group. a p < 0.05 and b p < 0.01 compared with the vehicle group. Abbreviations: ALN, alendronate; ELD, eldecalcitol; MIN, minodronate; OVX, ovariectomized; RIS, risedronate.

Article Snippet: ALN, MIN, and ELD were purchased from Wako Pure Chemical Industries (Tokyo, Japan), Chengdu-D-Innovation pharmaceutical (Chengdu, China), and Chugai Pharmaceutical (eldecalcitol capsule, Tokyo, Japan), respectively.

Techniques:

Journal: Bone Reports

Article Title: Effects of risedronate, alendronate, and minodronate alone or in combination with eldecalcitol on bone mineral density, quality, and strength in ovariectomized rats

doi: 10.1016/j.bonr.2021.101061

Figure Lengend Snippet: FTIR analysis and bone quality of L3 in OVX rats treated with bisphosphonates, eldecalcitol, or their combinations. Lumber vertebral bones were harvested from sham and OVX rats after 16 weeks. (A) FTIR images with areas of high absorbance for the PO 4 3− band shown as white (or red), and areas of low absorbance for the PO 4 3− band shown as dark blue. (B) Mineral-to-collagen matrix ratio of trabecular bone, (C) carbonate-to-phosphate ratio of trabecular bone, (D) mineral-to-collagen matrix ratio of cortical bone, and (E) carbonate-to-phosphate ratio of cortical bone. Data are presented as mean + SD. n = 3 (30 × 3 spectra). ⁎ p < 0.05 and ⁎⁎ p < 0.01 compared with the sham group. a p < 0.05, b p < 0.01, and c p < 0.001 compared with the vehicle group. † p < 0.05 and †† p < 0.01 compared with RIS. ‡‡‡‡ p < 0.0001 compared with ALN. ## p < 0.01 and ### p < 0.001 compared with MIN. $ p < 0.05 and $$$$ p < 0.0001 compared with ELD. § p < 0.05 and §§ p < 0.01 compared with RIS + ELD. ¶ p < 0.05 compared with ALN + ELD. Abbreviations: ALN, alendronate; ELD, eldecalcitol; FTIR, Fourier transform infrared; MIN, minodronate; OVX, ovariectomized; RIS, risedronate.

Article Snippet: ALN, MIN, and ELD were purchased from Wako Pure Chemical Industries (Tokyo, Japan), Chengdu-D-Innovation pharmaceutical (Chengdu, China), and Chugai Pharmaceutical (eldecalcitol capsule, Tokyo, Japan), respectively.

Techniques: Fourier Transform Infrared Spectroscopy

Journal: Bone Reports

Article Title: Effects of risedronate, alendronate, and minodronate alone or in combination with eldecalcitol on bone mineral density, quality, and strength in ovariectomized rats

doi: 10.1016/j.bonr.2021.101061

Figure Lengend Snippet: FTIR analysis and bone quality of the femurs in OVX rats treated with bisphosphonates, eldecalcitol, and their combinations. Right femoral bones were harvested from sham and OVX rats after 16 weeks. (A) FTIR images with areas of high absorbance for the PO 4 3− band shown as white (or red), and areas of low absorbance for the PO 4 3− band shown as dark blue. (B) Mineral-to-collagen matrix ratio of trabecular bone, (C) carbonate-to-phosphate ratio of trabecular bone, (D) mineral-to-collagen matrix ratio of cortical bone, and (E) carbonate-to-phosphate ratio of cortical bone. Data are presented as mean + SD. n = 3 (30 × 3 spectra). ⁎⁎ p < 0.001 compared with the sham group. a p < 0.05, b p < 0.01, and c p < 0.001 compared with the vehicle group. † p < 0.05 and †††† p < 0.0001 compared with RIS. ‡ p < 0.05, ‡‡ p < 0.01, and ‡‡‡ p < 0.001 compared with ALN. # p < 0.05 and ### p < 0.001 compared with MIN. $$ p < 0.01 and $$$ p < 0.001 compared with ELD. §§§§ p < 0.0001 compared with RIS + ELD. ¶¶¶¶ p < 0.0001 compared with ALN + ELD. Abbreviations: ALN, alendronate; ELD, eldecalcitol; FTIR, Fourier transform infrared; MIN, minodronate; OVX, ovariectomized; RIS, risedronate.

Article Snippet: ALN, MIN, and ELD were purchased from Wako Pure Chemical Industries (Tokyo, Japan), Chengdu-D-Innovation pharmaceutical (Chengdu, China), and Chugai Pharmaceutical (eldecalcitol capsule, Tokyo, Japan), respectively.

Techniques: Fourier Transform Infrared Spectroscopy