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Multistage exposure to increasing doses of DTG+ABC + 3TC inhibits OL maturation. (a) Diagram of multistage treatment paradigm with DTG+ABC + 3TC during OPC proliferation and OL differentiation. (b) Representative images of differentiated OLs after multistage treatment with DTG+ABC + 3TC and immunostained for GalC (green), PLP (red), and DAPI (blue). Scale bar = 75 µm. Quantification of the number of GalC + (c) and PLP + (d) cells shows significantly fewer differentiated OLs after multistage exposure to DTG+ABC + 3TC without an effect on total number of DAPI + cells (e), n = 3/group. f) Representative immunoblots of MBP and PLP after multistage exposure to DTG+ABC + 3TC. Densitometry analyses show significantly less MBP (g) and PLP (h) expression, n = 3/group. One-way ANOVA with Dunnett post-hoc test to compare all treatment groups to DMSO. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.

Journal: ASN NEURO

Article Title: Exposure to Frontline Antiretroviral Dolutegravir Disrupts Oligodendrocyte Development Across Differentiation Stages

doi: 10.1080/17590914.2026.2647877

Figure Lengend Snippet: Multistage exposure to increasing doses of DTG+ABC + 3TC inhibits OL maturation. (a) Diagram of multistage treatment paradigm with DTG+ABC + 3TC during OPC proliferation and OL differentiation. (b) Representative images of differentiated OLs after multistage treatment with DTG+ABC + 3TC and immunostained for GalC (green), PLP (red), and DAPI (blue). Scale bar = 75 µm. Quantification of the number of GalC + (c) and PLP + (d) cells shows significantly fewer differentiated OLs after multistage exposure to DTG+ABC + 3TC without an effect on total number of DAPI + cells (e), n = 3/group. f) Representative immunoblots of MBP and PLP after multistage exposure to DTG+ABC + 3TC. Densitometry analyses show significantly less MBP (g) and PLP (h) expression, n = 3/group. One-way ANOVA with Dunnett post-hoc test to compare all treatment groups to DMSO. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.

Article Snippet: In this study, OPCs were treated with the antiretroviral drugs DTG (Toronto Research Chemicals, D528800 and MedChemExpress, HY-13238), ABC (MedChemExpress, HY-17423), 3TC (MedChemExpress, HY-B0250), or a combination of all 3 drugs (identified as cART).

Techniques: Western Blot, Expressing

DTG, but not ABC or 3TC, significantly impairs OL maturation after multistage exposure. (a) Representative images of differentiated OLs after multistage treatment with DTG, ABC, or 3TC and immunostained for GalC (green), PLP (red), and DAPI (blue). Scale bar = 75 µm. Quantification of the number of GalC + and PLP + cells shows significantly fewer differentiated OLs without a change in DAPI after multistage exposure to DTG (b-d) but not ABC (e-g) or 3TC (h-j), n = 3/group. One-way ANOVA with Dunnett post-hoc test to compare all treatment groups to DMSO. ** p < 0.01, **** p < 0.0001.

Journal: ASN NEURO

Article Title: Exposure to Frontline Antiretroviral Dolutegravir Disrupts Oligodendrocyte Development Across Differentiation Stages

doi: 10.1080/17590914.2026.2647877

Figure Lengend Snippet: DTG, but not ABC or 3TC, significantly impairs OL maturation after multistage exposure. (a) Representative images of differentiated OLs after multistage treatment with DTG, ABC, or 3TC and immunostained for GalC (green), PLP (red), and DAPI (blue). Scale bar = 75 µm. Quantification of the number of GalC + and PLP + cells shows significantly fewer differentiated OLs without a change in DAPI after multistage exposure to DTG (b-d) but not ABC (e-g) or 3TC (h-j), n = 3/group. One-way ANOVA with Dunnett post-hoc test to compare all treatment groups to DMSO. ** p < 0.01, **** p < 0.0001.

Article Snippet: In this study, OPCs were treated with the antiretroviral drugs DTG (Toronto Research Chemicals, D528800 and MedChemExpress, HY-13238), ABC (MedChemExpress, HY-17423), 3TC (MedChemExpress, HY-B0250), or a combination of all 3 drugs (identified as cART).

Techniques:

DTG, but not ABC or 3TC, significantly reduces myelin protein expression after multistage exposure. (a) Representative immunoblots of MBP and PLP after multistage exposure to DTG (800 nM, 8 µM, or 24 µM). Densitometry analyses show significantly less MBP after exposure to 800 nM, 8 µM, or 24 µM DTG (b) and PLP after exposure to 24 µM DTG (c), n = 3/group. (d) Representative immunoblots of MBP and PLP after multistage exposure to ABC (150 nM, 1.5 µM, or 4.5 µM). Densitometry analyses show no changes in MBP (e) or PLP (f) expression, n = 3/group. g) Representative immunoblots of MBP and PLP after multistage exposure to 3TC (600 nM, 6 µM, or 18 µM). Densitometry analyses show no changes in MBP (h) or PLP (i) expression, n = 3/group. One-way ANOVA with Dunnett post-hoc test to compare all treatment groups to DMSO. ** p < 0.01, **** p < 0.0001.

Journal: ASN NEURO

Article Title: Exposure to Frontline Antiretroviral Dolutegravir Disrupts Oligodendrocyte Development Across Differentiation Stages

doi: 10.1080/17590914.2026.2647877

Figure Lengend Snippet: DTG, but not ABC or 3TC, significantly reduces myelin protein expression after multistage exposure. (a) Representative immunoblots of MBP and PLP after multistage exposure to DTG (800 nM, 8 µM, or 24 µM). Densitometry analyses show significantly less MBP after exposure to 800 nM, 8 µM, or 24 µM DTG (b) and PLP after exposure to 24 µM DTG (c), n = 3/group. (d) Representative immunoblots of MBP and PLP after multistage exposure to ABC (150 nM, 1.5 µM, or 4.5 µM). Densitometry analyses show no changes in MBP (e) or PLP (f) expression, n = 3/group. g) Representative immunoblots of MBP and PLP after multistage exposure to 3TC (600 nM, 6 µM, or 18 µM). Densitometry analyses show no changes in MBP (h) or PLP (i) expression, n = 3/group. One-way ANOVA with Dunnett post-hoc test to compare all treatment groups to DMSO. ** p < 0.01, **** p < 0.0001.

Article Snippet: In this study, OPCs were treated with the antiretroviral drugs DTG (Toronto Research Chemicals, D528800 and MedChemExpress, HY-13238), ABC (MedChemExpress, HY-17423), 3TC (MedChemExpress, HY-B0250), or a combination of all 3 drugs (identified as cART).

Techniques: Expressing, Western Blot