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Innovassynth Technologies India 5′‐ o ‐dmt‐3′‐ o ‐phosphoramidites of nucleosides
Modified <t>nucleosides</t> used to introduce 1,4‐disubstituted triazole cross‐links into G4 DNA. Top: commercially available 2′‐ O ‐propargylguanosine phosphoramidite ( Y ‐monomer); bottom: N 6 ‐modified adenosine H‐phosphonate containing azide ( Z ‐monomer). These modifications were incorporated during DNA synthesis and then cross‐linked post‐synthetically to form the thermodynamically trapped G4s shown. A G3A8 cross‐link in the 12‐mer telomeric sequence is proposed to reinforce the parallel G4 topology shown in (A) whereas a G5A8 cross‐link should form a G4 of antiparallel topology shown in (B).
5′‐ O ‐Dmt‐3′‐ O ‐Phosphoramidites Of Nucleosides, supplied by Innovassynth Technologies India, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Modified <t>nucleosides</t> used to introduce 1,4‐disubstituted triazole cross‐links into G4 DNA. Top: commercially available 2′‐ O ‐propargylguanosine phosphoramidite ( Y ‐monomer); bottom: N 6 ‐modified adenosine H‐phosphonate containing azide ( Z ‐monomer). These modifications were incorporated during DNA synthesis and then cross‐linked post‐synthetically to form the thermodynamically trapped G4s shown. A G3A8 cross‐link in the 12‐mer telomeric sequence is proposed to reinforce the parallel G4 topology shown in (A) whereas a G5A8 cross‐link should form a G4 of antiparallel topology shown in (B).
Dmt Nucleoside Succinyl Cpg, supplied by Glen Research, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Modified <t>nucleosides</t> used to introduce 1,4‐disubstituted triazole cross‐links into G4 DNA. Top: commercially available 2′‐ O ‐propargylguanosine phosphoramidite ( Y ‐monomer); bottom: N 6 ‐modified adenosine H‐phosphonate containing azide ( Z ‐monomer). These modifications were incorporated during DNA synthesis and then cross‐linked post‐synthetically to form the thermodynamically trapped G4s shown. A G3A8 cross‐link in the 12‐mer telomeric sequence is proposed to reinforce the parallel G4 topology shown in (A) whereas a G5A8 cross‐link should form a G4 of antiparallel topology shown in (B).
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phosphoramidites of 5′-o-dmt-nucleosides  (Glen Research)
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Modified <t>nucleosides</t> used to introduce 1,4‐disubstituted triazole cross‐links into G4 DNA. Top: commercially available 2′‐ O ‐propargylguanosine phosphoramidite ( Y ‐monomer); bottom: N 6 ‐modified adenosine H‐phosphonate containing azide ( Z ‐monomer). These modifications were incorporated during DNA synthesis and then cross‐linked post‐synthetically to form the thermodynamically trapped G4s shown. A G3A8 cross‐link in the 12‐mer telomeric sequence is proposed to reinforce the parallel G4 topology shown in (A) whereas a G5A8 cross‐link should form a G4 of antiparallel topology shown in (B).
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Modified <t>nucleosides</t> used to introduce 1,4‐disubstituted triazole cross‐links into G4 DNA. Top: commercially available 2′‐ O ‐propargylguanosine phosphoramidite ( Y ‐monomer); bottom: N 6 ‐modified adenosine H‐phosphonate containing azide ( Z ‐monomer). These modifications were incorporated during DNA synthesis and then cross‐linked post‐synthetically to form the thermodynamically trapped G4s shown. A G3A8 cross‐link in the 12‐mer telomeric sequence is proposed to reinforce the parallel G4 topology shown in (A) whereas a G5A8 cross‐link should form a G4 of antiparallel topology shown in (B).
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nucleoside 5´-dmt 3´-phosphoramidites  (Glen Research)
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Modified <t>nucleosides</t> used to introduce 1,4‐disubstituted triazole cross‐links into G4 DNA. Top: commercially available 2′‐ O ‐propargylguanosine phosphoramidite ( Y ‐monomer); bottom: N 6 ‐modified adenosine H‐phosphonate containing azide ( Z ‐monomer). These modifications were incorporated during DNA synthesis and then cross‐linked post‐synthetically to form the thermodynamically trapped G4s shown. A G3A8 cross‐link in the 12‐mer telomeric sequence is proposed to reinforce the parallel G4 topology shown in (A) whereas a G5A8 cross‐link should form a G4 of antiparallel topology shown in (B).
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nucleoside phosphoramidites dmt-o-ch2ch2-so2-ch2ch2-o-p(ocne)nipr2  (Glen Research)
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Modified <t>nucleosides</t> used to introduce 1,4‐disubstituted triazole cross‐links into G4 DNA. Top: commercially available 2′‐ O ‐propargylguanosine phosphoramidite ( Y ‐monomer); bottom: N 6 ‐modified adenosine H‐phosphonate containing azide ( Z ‐monomer). These modifications were incorporated during DNA synthesis and then cross‐linked post‐synthetically to form the thermodynamically trapped G4s shown. A G3A8 cross‐link in the 12‐mer telomeric sequence is proposed to reinforce the parallel G4 topology shown in (A) whereas a G5A8 cross‐link should form a G4 of antiparallel topology shown in (B).
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dmt-nucleoside  (ChemGenes corporation)
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Modified <t>nucleosides</t> used to introduce 1,4‐disubstituted triazole cross‐links into G4 DNA. Top: commercially available 2′‐ O ‐propargylguanosine phosphoramidite ( Y ‐monomer); bottom: N 6 ‐modified adenosine H‐phosphonate containing azide ( Z ‐monomer). These modifications were incorporated during DNA synthesis and then cross‐linked post‐synthetically to form the thermodynamically trapped G4s shown. A G3A8 cross‐link in the 12‐mer telomeric sequence is proposed to reinforce the parallel G4 topology shown in (A) whereas a G5A8 cross‐link should form a G4 of antiparallel topology shown in (B).
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https://www.bioz.com/product/dmt-nucleoside/dmt+nucleoside/pm19523922-35-13-24
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Modified nucleosides used to introduce 1,4‐disubstituted triazole cross‐links into G4 DNA. Top: commercially available 2′‐ O ‐propargylguanosine phosphoramidite ( Y ‐monomer); bottom: N 6 ‐modified adenosine H‐phosphonate containing azide ( Z ‐monomer). These modifications were incorporated during DNA synthesis and then cross‐linked post‐synthetically to form the thermodynamically trapped G4s shown. A G3A8 cross‐link in the 12‐mer telomeric sequence is proposed to reinforce the parallel G4 topology shown in (A) whereas a G5A8 cross‐link should form a G4 of antiparallel topology shown in (B).

Journal: Chemistry (Weinheim an Der Bergstrasse, Germany)

Article Title: Controlling Topology of a Telomeric G‐quadruplex DNA With a Chemical Cross‐link

doi: 10.1002/chem.202501467

Figure Lengend Snippet: Modified nucleosides used to introduce 1,4‐disubstituted triazole cross‐links into G4 DNA. Top: commercially available 2′‐ O ‐propargylguanosine phosphoramidite ( Y ‐monomer); bottom: N 6 ‐modified adenosine H‐phosphonate containing azide ( Z ‐monomer). These modifications were incorporated during DNA synthesis and then cross‐linked post‐synthetically to form the thermodynamically trapped G4s shown. A G3A8 cross‐link in the 12‐mer telomeric sequence is proposed to reinforce the parallel G4 topology shown in (A) whereas a G5A8 cross‐link should form a G4 of antiparallel topology shown in (B).

Article Snippet: Standard 5′‐ O ‐DMT‐3′‐ O ‐phosphoramidites of nucleosides were obtained from Innovassynth Technologies (I) Ltd (India) and the 2′‐ O ‐propargylguanosine phosphoramidite was obtained from Chemgenes Corporation (USA).

Techniques: Modification, Introduce, DNA Synthesis, Sequencing