Journal:

Article Title: Lesion size-dependent synaptic and astrocytic responses in cortex contralateral to infarcts in middle aged rats

doi: 10.1002/syn.20777

Figure Lengend Snippet: Axodendritic synapses (white arrows) were identified in transmission electron micrographs (A, scale bar=500nm). Synapse number per neuron was negatively correlated with lesion size (B). A median split divided the lesion group into two subgroups. Representative Nissl stained coronal sections and lesion reconstructions are shown for the two lesion sizes (C). The open rectangle in the contralesional cortex of the photomicrographs indicates the layer V sample region for the synaptic and neuronal density estimates. Numbers are coordinates in mm relative to bregma. Scale bar = 1 mm. In C, lesion reconstructions from different animals are overlaid so that the darker color indicates greater overlap of lesion territory between brains. In the Schallert cylinder test (D), the Large Lesion group had significantly reduced use of the impaired limb compared to the Shams (*p<0.05).

Article Snippet: Four sets of four serially positioned digital electron micrographs per brain were obtained using a Philips EM 208 transmission electron microscope with an AMT advantage HR 1MB digital camera (14,000× image capture magnification; digitally viewed at a final magnification of 42,000×).

Techniques: Transmission Assay, Staining

Journal:

Article Title: Lesion size-dependent synaptic and astrocytic responses in cortex contralateral to infarcts in middle aged rats

doi: 10.1002/syn.20777

Figure Lengend Snippet: Astrocytic hypertrophy in the contralesional homotopic cortex. Astrocytic processes (asterisks) were identified in electron micrographs (A, scale bar=500nm). Increased astrocytic process volume per neuron was observed only in the Small Lesion group compared with Sham (B, *p<0.05, †p<0.01).

Article Snippet: Four sets of four serially positioned digital electron micrographs per brain were obtained using a Philips EM 208 transmission electron microscope with an AMT advantage HR 1MB digital camera (14,000× image capture magnification; digitally viewed at a final magnification of 42,000×).

Techniques: