Journal: Physics in medicine and biology

Article Title: A multi-frequency sparse hemispherical ultrasound phased array for microbubble-mediated transcranial therapy and simultaneous cavitation mapping

doi: 10.1088/0031-9155/61/24/8476

Figure Lengend Snippet: (a) Lateral (top row) and axial (bottom row) images of microbubble clouds located near the array's geometric focus reconstructed at 306 kHz (0.53 MPa estimated in-situ pressure), 612 kHz (0.27 MPa estimated in-situ pressure), and 1.224 MHz (0.23 MPa estimated in-situ pressure), respectively, through an ex-vivo human skullcap using source-based aberration corrections. Please note that the scale bars used in each sub plot in figure 10(a) are different. (b) Frequency spectrum of the beamformed signal at the point of maximum intensity is given for each of the cases in (a). (c) Normalized maximum pixel projection images of the tube phantom obtained through an ex-vivo human skullcap. Images were captured at both the half-harmonic (612 kHz transmit frequency, 0.53 MPa estimated in-situ pressure) and the second-harmonic (306 kHz transmit frequency, 0.27 MPa estimated in-situ pressure), and were reconstructed with and without the use of source-based aberration corrections on receive. The cross-sectional images (bottom row) were generated by taking the maximum pixel projection over the range of [−1,1] mm in Y.

Article Snippet: The receiving capabilities of the array were investigated by imaging ultrasound-stimulated microbubbles (DefinityTM, Lantheus Medical Imaging, North Billerica, MA, USA) flowing through thin-walled tube phantoms (Cole-Parmer, Vernon Hills, IL, USA).

Techniques: In Situ, Ex Vivo, Generated

Journal: Physics in medicine and biology

Article Title: A multi-frequency sparse hemispherical ultrasound phased array for microbubble-mediated transcranial therapy and simultaneous cavitation mapping

doi: 10.1088/0031-9155/61/24/8476

Figure Lengend Snippet: (a). Contrast-enhanced T1-weighted MR image of the rat taken with contrast following FUS+microbubbles (MBs). (b). Corresponding passive acoustic maps from the burst 30 s into the sonication for sonications with MBs and BBB opening. The lateral plane of maximum intensity pixel projection is shown. (c) Frequency spectrum of the beamformed signal at the point of maximum intensity in (b) is given.

Article Snippet: The receiving capabilities of the array were investigated by imaging ultrasound-stimulated microbubbles (DefinityTM, Lantheus Medical Imaging, North Billerica, MA, USA) flowing through thin-walled tube phantoms (Cole-Parmer, Vernon Hills, IL, USA).

Techniques: Sonication

Journal: Physics in medicine and biology

Article Title: A multi-frequency sparse hemispherical ultrasound phased array for microbubble-mediated transcranial therapy and simultaneous cavitation mapping

doi: 10.1088/0031-9155/61/24/8476

Figure Lengend Snippet: (a) Lateral (top row) and axial (bottom row) images of microbubble clouds located near the array's geometric focus reconstructed at 306 kHz (0.53 MPa estimated in-situ pressure), 612 kHz (0.27 MPa estimated in-situ pressure), and 1.224 MHz (0.23 MPa estimated in-situ pressure), respectively, through an ex-vivo human skullcap using source-based aberration corrections. Please note that the scale bars used in each sub plot in figure 10(a) are different. (b) Frequency spectrum of the beamformed signal at the point of maximum intensity is given for each of the cases in (a). (c) Normalized maximum pixel projection images of the tube phantom obtained through an ex-vivo human skullcap. Images were captured at both the half-harmonic (612 kHz transmit frequency, 0.53 MPa estimated in-situ pressure) and the second-harmonic (306 kHz transmit frequency, 0.27 MPa estimated in-situ pressure), and were reconstructed with and without the use of source-based aberration corrections on receive. The cross-sectional images (bottom row) were generated by taking the maximum pixel projection over the range of [−1,1] mm in Y.

Article Snippet: C. Receiver Array Characterization: Passive Microbubble Imaging The receiving capabilities of the array were investigated by imaging ultrasound-stimulated microbubbles (Definity™, Lantheus Medical Imaging, North Billerica, MA, USA) flowing through thin-walled tube phantoms (Cole-Parmer, Vernon Hills, IL, USA).

Techniques: In Situ, Ex Vivo, Generated

Journal: Physics in medicine and biology

Article Title: A multi-frequency sparse hemispherical ultrasound phased array for microbubble-mediated transcranial therapy and simultaneous cavitation mapping

doi: 10.1088/0031-9155/61/24/8476

Figure Lengend Snippet: (a). Contrast-enhanced T1-weighted MR image of the rat taken with contrast following FUS+microbubbles (MBs). (b). Corresponding passive acoustic maps from the burst 30 s into the sonication for sonications with MBs and BBB opening. The lateral plane of maximum intensity pixel projection is shown. (c) Frequency spectrum of the beamformed signal at the point of maximum intensity in (b) is given.

Article Snippet: C. Receiver Array Characterization: Passive Microbubble Imaging The receiving capabilities of the array were investigated by imaging ultrasound-stimulated microbubbles (Definity™, Lantheus Medical Imaging, North Billerica, MA, USA) flowing through thin-walled tube phantoms (Cole-Parmer, Vernon Hills, IL, USA).

Techniques: Sonication