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VVD-065 exhibits strong antitumor effects in syngeneic settings. A and B, Antitumor efficacy of VVD-065 in the KLN-205 syngeneic orthotopic model. KLN-205 cells were injected into the tail vein <t>of</t> <t>DBA/2</t> animals and then dosed with vehicle or VVD-065 50 mg/kg once a day (QD). A, Representative hematoxylin and eosin images of lungs from non-tumor bearing animals, vehicle-treated animals, and VVD-065–treated animals. B, Kaplan–Meier survival analysis comparing VVD-065 with vehicle ( n = 30 animals/group). Statistical significance was calculated by the Gehan–Breslow–Wilcoxon test (****, P < 0.0001). C, Antitumor efficacy of VVD-065 in the KLN-205 syngeneic heterotopic model. Data are shown as mean ± SEM; n = 10 animals/group. Mice were dosed orally with VVD-065 at indicated doses. Statistical significance was calculated by two-way ANOVA (****, P ≤ 0.0001). OS, overall survival.
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VVD-065 exhibits strong antitumor effects in syngeneic settings. A and B, Antitumor efficacy of VVD-065 in the KLN-205 syngeneic orthotopic model. KLN-205 cells were injected into the tail vein <t>of</t> <t>DBA/2</t> animals and then dosed with vehicle or VVD-065 50 mg/kg once a day (QD). A, Representative hematoxylin and eosin images of lungs from non-tumor bearing animals, vehicle-treated animals, and VVD-065–treated animals. B, Kaplan–Meier survival analysis comparing VVD-065 with vehicle ( n = 30 animals/group). Statistical significance was calculated by the Gehan–Breslow–Wilcoxon test (****, P < 0.0001). C, Antitumor efficacy of VVD-065 in the KLN-205 syngeneic heterotopic model. Data are shown as mean ± SEM; n = 10 animals/group. Mice were dosed orally with VVD-065 at indicated doses. Statistical significance was calculated by two-way ANOVA (****, P ≤ 0.0001). OS, overall survival.
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VVD-065 exhibits strong antitumor effects in syngeneic settings. A and B, Antitumor efficacy of VVD-065 in the KLN-205 syngeneic orthotopic model. KLN-205 cells were injected into the tail vein <t>of</t> <t>DBA/2</t> animals and then dosed with vehicle or VVD-065 50 mg/kg once a day (QD). A, Representative hematoxylin and eosin images of lungs from non-tumor bearing animals, vehicle-treated animals, and VVD-065–treated animals. B, Kaplan–Meier survival analysis comparing VVD-065 with vehicle ( n = 30 animals/group). Statistical significance was calculated by the Gehan–Breslow–Wilcoxon test (****, P < 0.0001). C, Antitumor efficacy of VVD-065 in the KLN-205 syngeneic heterotopic model. Data are shown as mean ± SEM; n = 10 animals/group. Mice were dosed orally with VVD-065 at indicated doses. Statistical significance was calculated by two-way ANOVA (****, P ≤ 0.0001). OS, overall survival.
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VVD-065 exhibits strong antitumor effects in syngeneic settings. A and B, Antitumor efficacy of VVD-065 in the KLN-205 syngeneic orthotopic model. KLN-205 cells were injected into the tail vein <t>of</t> <t>DBA/2</t> animals and then dosed with vehicle or VVD-065 50 mg/kg once a day (QD). A, Representative hematoxylin and eosin images of lungs from non-tumor bearing animals, vehicle-treated animals, and VVD-065–treated animals. B, Kaplan–Meier survival analysis comparing VVD-065 with vehicle ( n = 30 animals/group). Statistical significance was calculated by the Gehan–Breslow–Wilcoxon test (****, P < 0.0001). C, Antitumor efficacy of VVD-065 in the KLN-205 syngeneic heterotopic model. Data are shown as mean ± SEM; n = 10 animals/group. Mice were dosed orally with VVD-065 at indicated doses. Statistical significance was calculated by two-way ANOVA (****, P ≤ 0.0001). OS, overall survival.
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VVD-065 exhibits strong antitumor effects in syngeneic settings. A and B, Antitumor efficacy of VVD-065 in the KLN-205 syngeneic orthotopic model. KLN-205 cells were injected into the tail vein <t>of</t> <t>DBA/2</t> animals and then dosed with vehicle or VVD-065 50 mg/kg once a day (QD). A, Representative hematoxylin and eosin images of lungs from non-tumor bearing animals, vehicle-treated animals, and VVD-065–treated animals. B, Kaplan–Meier survival analysis comparing VVD-065 with vehicle ( n = 30 animals/group). Statistical significance was calculated by the Gehan–Breslow–Wilcoxon test (****, P < 0.0001). C, Antitumor efficacy of VVD-065 in the KLN-205 syngeneic heterotopic model. Data are shown as mean ± SEM; n = 10 animals/group. Mice were dosed orally with VVD-065 at indicated doses. Statistical significance was calculated by two-way ANOVA (****, P ≤ 0.0001). OS, overall survival.
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VVD-065 exhibits strong antitumor effects in syngeneic settings. A and B, Antitumor efficacy of VVD-065 in the KLN-205 syngeneic orthotopic model. KLN-205 cells were injected into the tail vein of DBA/2 animals and then dosed with vehicle or VVD-065 50 mg/kg once a day (QD). A, Representative hematoxylin and eosin images of lungs from non-tumor bearing animals, vehicle-treated animals, and VVD-065–treated animals. B, Kaplan–Meier survival analysis comparing VVD-065 with vehicle ( n = 30 animals/group). Statistical significance was calculated by the Gehan–Breslow–Wilcoxon test (****, P < 0.0001). C, Antitumor efficacy of VVD-065 in the KLN-205 syngeneic heterotopic model. Data are shown as mean ± SEM; n = 10 animals/group. Mice were dosed orally with VVD-065 at indicated doses. Statistical significance was calculated by two-way ANOVA (****, P ≤ 0.0001). OS, overall survival.

Journal: Cancer Discovery

Article Title: A Covalent Allosteric Molecular Glue Suppresses NRF2-Dependent Cancer Growth

doi: 10.1158/2159-8290.CD-25-1187

Figure Lengend Snippet: VVD-065 exhibits strong antitumor effects in syngeneic settings. A and B, Antitumor efficacy of VVD-065 in the KLN-205 syngeneic orthotopic model. KLN-205 cells were injected into the tail vein of DBA/2 animals and then dosed with vehicle or VVD-065 50 mg/kg once a day (QD). A, Representative hematoxylin and eosin images of lungs from non-tumor bearing animals, vehicle-treated animals, and VVD-065–treated animals. B, Kaplan–Meier survival analysis comparing VVD-065 with vehicle ( n = 30 animals/group). Statistical significance was calculated by the Gehan–Breslow–Wilcoxon test (****, P < 0.0001). C, Antitumor efficacy of VVD-065 in the KLN-205 syngeneic heterotopic model. Data are shown as mean ± SEM; n = 10 animals/group. Mice were dosed orally with VVD-065 at indicated doses. Statistical significance was calculated by two-way ANOVA (****, P ≤ 0.0001). OS, overall survival.

Article Snippet: KLN-205 cells were harvested in the exponential growth phase and suspended in 100 μL PBS to deliver 0.5 × 10 6 cells via a tail vein injection in DBA/2 mice (The Jackson Laboratory).

Techniques: Injection