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Biodistribution of M2-EVs@DNase I in septic mice. (A) Representative in vivo fluorescence images of septic mice following intravenous injection of Cy5.5-labeled DNase I or M2-EVs@DNase I at 3, 6, 12, and 24 h. (B) Ex vivo fluorescence images of major organs at 24 h post-administration. (C) Quantitative results of fluorescence intensity in major organs. n = 3. Data are mean ± SD. * P < 0.05, ** P < 0.01.

Journal: International Journal of Pharmaceutics: X

Article Title: Engineered M2 macrophage-derived vesicles deliver DNase I for cfDNA clearance and multi-organ protection in sepsis

doi: 10.1016/j.ijpx.2026.100528

Figure Lengend Snippet: Biodistribution of M2-EVs@DNase I in septic mice. (A) Representative in vivo fluorescence images of septic mice following intravenous injection of Cy5.5-labeled DNase I or M2-EVs@DNase I at 3, 6, 12, and 24 h. (B) Ex vivo fluorescence images of major organs at 24 h post-administration. (C) Quantitative results of fluorescence intensity in major organs. n = 3. Data are mean ± SD. * P < 0.05, ** P < 0.01.

Article Snippet: Cyanine5.5 (Cy5.5) and DNase I were acquired from MedChemExpress (MCE, NJ, USA).

Techniques: In Vivo, Fluorescence, Injection, Labeling, Ex Vivo