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Open Field test in different experimental groups (control, sham, and α-syn) at one, two, and four months post-injection. Spontaneous global activity (a) , locomotion (b) , and mean velocity (c) were measured in an Open Field arena. Activity detection was fully automated using custom-designed software <t>Actitrack</t> (Panlab, Spain). Data are presented as mean ± SEM. * p < 0.05, ** p < 0.01 (one-way ANOVA with post hoc corrections; n = 12 in each experimental group). (d) Temporal analysis assessing the progression of global activity. Data are presented as mean ± SEM. ***(time) p < 0.001; # (α-syn vs. control) p < 0.05 (multivariate linear regression analysis)
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Open Field test in different experimental groups (control, sham, and α-syn) at one, two, and four months post-injection. Spontaneous global activity (a) , locomotion (b) , and mean velocity (c) were measured in an Open Field arena. Activity detection was fully automated using custom-designed software <t>Actitrack</t> (Panlab, Spain). Data are presented as mean ± SEM. * p < 0.05, ** p < 0.01 (one-way ANOVA with post hoc corrections; n = 12 in each experimental group). (d) Temporal analysis assessing the progression of global activity. Data are presented as mean ± SEM. ***(time) p < 0.001; # (α-syn vs. control) p < 0.05 (multivariate linear regression analysis)
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Open Field test in different experimental groups (control, sham, and α-syn) at one, two, and four months post-injection. Spontaneous global activity (a) , locomotion (b) , and mean velocity (c) were measured in an Open Field arena. Activity detection was fully automated using custom-designed software Actitrack (Panlab, Spain). Data are presented as mean ± SEM. * p < 0.05, ** p < 0.01 (one-way ANOVA with post hoc corrections; n = 12 in each experimental group). (d) Temporal analysis assessing the progression of global activity. Data are presented as mean ± SEM. ***(time) p < 0.001; # (α-syn vs. control) p < 0.05 (multivariate linear regression analysis)

Journal: Brain Structure & Function

Article Title: Temporal progression of pathological features in an α-synuclein overexpression model of Parkinson’s disease

doi: 10.1007/s00429-025-02959-9

Figure Lengend Snippet: Open Field test in different experimental groups (control, sham, and α-syn) at one, two, and four months post-injection. Spontaneous global activity (a) , locomotion (b) , and mean velocity (c) were measured in an Open Field arena. Activity detection was fully automated using custom-designed software Actitrack (Panlab, Spain). Data are presented as mean ± SEM. * p < 0.05, ** p < 0.01 (one-way ANOVA with post hoc corrections; n = 12 in each experimental group). (d) Temporal analysis assessing the progression of global activity. Data are presented as mean ± SEM. ***(time) p < 0.001; # (α-syn vs. control) p < 0.05 (multivariate linear regression analysis)

Article Snippet: The detection of global activity, locomotion and mean velocity was fully automated using the custom-designed software Actitrack (Panlab, Spain).

Techniques: Control, Injection, Activity Assay, Software