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Image Search Results


AI-driven design of LNP–CRISPR platforms for immune cell engineering.

Journal: Materials Today Bio

Article Title: Delivering the future of immunotherapy: A state-of-the-art review of gene editing in immune cells with lipid nanoparticles

doi: 10.1016/j.mtbio.2026.103334

Figure Lengend Snippet: AI-driven design of LNP–CRISPR platforms for immune cell engineering.

Article Snippet: This transition is reflected in the momentum across the biotech landscape, where LNP-CRISPR platforms are advancing rapidly, from clinical-stage efforts by Intellia, Verve (acquired by Eli Lilly for $1.3B in June 2025) and CRISPR Therapeutics to preclinical innovation at companies like Beam, Prime Medicine, and ReCode.

Techniques: CRISPR

U2OS cells with inactivation of the WDR75 gene locus and ectopic expression of WDR75 p.T46I present with altered pre-rRNA processing. (A) Sanger sequences of gDNA at the site (guide sequence) of CRISPR/Cas9 modification of different U2OS clones ectopically expressing either WDR75 WT or WDR75 p.T46I. (B) Alignments of sequencing profiles from TOPO TA cloned RT-PCR products of U2OS cells modified by CRISPR/Cas9. U2OS cells were treated with CHX 100 µg/ml for 2 h before extracting the RNA. (C) Northern blot analysis of U2OS cells ectopically expressing a pWPI EV, WDR75 WT, or WDR75 p.T46I (M1). The WDR75 gene locus was inactivated (see A and B) in WT- and WDR75 p.T46I-expressing U2OS cells. Indicated radiolabeled probes were used to detect pre-rRNA precursors and mature rRNAs. Statistical analysis presented in C was performed using paired Student’s t test; *P < 0.05; **P < 0.01. Source data are available for this figure: .

Journal: Journal of Human Immunity

Article Title: Ribosomal RNA processing impairments in a B cell immunodeficient patient with WDR75 variants

doi: 10.70962/jhi.20250061

Figure Lengend Snippet: U2OS cells with inactivation of the WDR75 gene locus and ectopic expression of WDR75 p.T46I present with altered pre-rRNA processing. (A) Sanger sequences of gDNA at the site (guide sequence) of CRISPR/Cas9 modification of different U2OS clones ectopically expressing either WDR75 WT or WDR75 p.T46I. (B) Alignments of sequencing profiles from TOPO TA cloned RT-PCR products of U2OS cells modified by CRISPR/Cas9. U2OS cells were treated with CHX 100 µg/ml for 2 h before extracting the RNA. (C) Northern blot analysis of U2OS cells ectopically expressing a pWPI EV, WDR75 WT, or WDR75 p.T46I (M1). The WDR75 gene locus was inactivated (see A and B) in WT- and WDR75 p.T46I-expressing U2OS cells. Indicated radiolabeled probes were used to detect pre-rRNA precursors and mature rRNAs. Statistical analysis presented in C was performed using paired Student’s t test; *P < 0.05; **P < 0.01. Source data are available for this figure: .

Article Snippet: KO score for each sequence was evaluated using Inference of CRISPR Edits (RRID:SCR_024508) software (Performance Analysis, 2019. v3.0; Synthego).

Techniques: Expressing, Sequencing, CRISPR, Modification, Clone Assay, Reverse Transcription Polymerase Chain Reaction, Northern Blot