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In vitro anti-RSV activity.

Journal: Viruses

Article Title: Interaction Between the Matrix Protein and the Polymerase Complex of Respiratory Syncytial Virus

doi: 10.3390/v16121881

Figure Lengend Snippet: In vitro anti-RSV activity.

Article Snippet: PC786 [ ], PC751 (compound 4a in [ ]), and AZ-27 [ ] compounds were synthesised by Sygnature Discovery Ltd. (Nottingham, UK; with final purities >98%).

Techniques: In Vitro, Activity Assay

Changes in viral load in vehicle, PC786- and PC751-treated ALI-cultured bronchial epithelium post RSV (0.002 MOI) apical inoculation. PC786 or PC751 was added to the apical surface, once daily from Day 0 (1 h after virus inoculation) to Day 6. The assay was conducted in triplicate, and the graph indicates geometric mean with 95% CI.

Journal: Viruses

Article Title: Interaction Between the Matrix Protein and the Polymerase Complex of Respiratory Syncytial Virus

doi: 10.3390/v16121881

Figure Lengend Snippet: Changes in viral load in vehicle, PC786- and PC751-treated ALI-cultured bronchial epithelium post RSV (0.002 MOI) apical inoculation. PC786 or PC751 was added to the apical surface, once daily from Day 0 (1 h after virus inoculation) to Day 6. The assay was conducted in triplicate, and the graph indicates geometric mean with 95% CI.

Article Snippet: PC786 [ ], PC751 (compound 4a in [ ]), and AZ-27 [ ] compounds were synthesised by Sygnature Discovery Ltd. (Nottingham, UK; with final purities >98%).

Techniques: Cell Culture, Virus

SNP genotype analysis of the L-gene of RSV A2 treated with PC786 ( A ), PC751 ( B ) or wild-type RSV A2 (passage 6), and also of the M-gene of RSV A2 treated with PC786 ( C ). The axes show the relative fluorescence of the probes specific to either the WT or mutant sequence of the L-gene or M-gene.

Journal: Viruses

Article Title: Interaction Between the Matrix Protein and the Polymerase Complex of Respiratory Syncytial Virus

doi: 10.3390/v16121881

Figure Lengend Snippet: SNP genotype analysis of the L-gene of RSV A2 treated with PC786 ( A ), PC751 ( B ) or wild-type RSV A2 (passage 6), and also of the M-gene of RSV A2 treated with PC786 ( C ). The axes show the relative fluorescence of the probes specific to either the WT or mutant sequence of the L-gene or M-gene.

Article Snippet: PC786 [ ], PC751 (compound 4a in [ ]), and AZ-27 [ ] compounds were synthesised by Sygnature Discovery Ltd. (Nottingham, UK; with final purities >98%).

Techniques: Fluorescence, Mutagenesis, Sequencing

PC786 treatment results in increased nuclear retention of GFP-M. Cells transfected to express GFP-Mwt were treated with 100 nM PC751 or PC786, DMSO (vehicle), or left untreated (NT) for 12 h before imaging live at 24 h post transfection. Fn/c for M protein was calculated using the formula Fn/c = (Fn − Fb)/(Fc − Fb), where Fn = nuclear fluorescence, Fc = cytoplasmic fluorescence, Fb = background autofluorescence. Unpaired Student’s t test was used to determine statistical differences indicated on the graphs. Statistical significance was set at p < 0.05. **— p < 0.001, ***— p < 0.0001, ****— p < 0.00001, ns—non significant.

Journal: Viruses

Article Title: Interaction Between the Matrix Protein and the Polymerase Complex of Respiratory Syncytial Virus

doi: 10.3390/v16121881

Figure Lengend Snippet: PC786 treatment results in increased nuclear retention of GFP-M. Cells transfected to express GFP-Mwt were treated with 100 nM PC751 or PC786, DMSO (vehicle), or left untreated (NT) for 12 h before imaging live at 24 h post transfection. Fn/c for M protein was calculated using the formula Fn/c = (Fn − Fb)/(Fc − Fb), where Fn = nuclear fluorescence, Fc = cytoplasmic fluorescence, Fb = background autofluorescence. Unpaired Student’s t test was used to determine statistical differences indicated on the graphs. Statistical significance was set at p < 0.05. **— p < 0.001, ***— p < 0.0001, ****— p < 0.00001, ns—non significant.

Article Snippet: PC786 [ ], PC751 (compound 4a in [ ]), and AZ-27 [ ] compounds were synthesised by Sygnature Discovery Ltd. (Nottingham, UK; with final purities >98%).

Techniques: Transfection, Imaging, Fluorescence