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dreadd agonist compound 21  (Tocris)
95
Tocris dreadd agonist compound 21
Effects of SST+ interneuron activation across different stages of spatial memory processing (A) Male and female SST-CRE mice ( n = 9 animals/group for encoding and consolidation; n = 14–15 animals/group for retrieval) are transduced to express Cre-dependent hM3Dq-mCitrine or EGFP (control) in DG. Beginning four weeks after viral transduction, SST+ interneurons were activated separately either during OLM encoding, consolidation, or retrieval, with two weeks of rest between OLM trials, which ended with a final trial in which vehicle is administered prior to encoding. (B) Timing of <t>compound</t> <t>21</t> (C21) administration relative to OLM encoding, consolidation, or retrieval. Mouse interaction with the moved vs. unmoved object is quantified to generate the OLM discrimination index (DI). (C–E) Discrimination index scores for encoding (C), consolidation (D), and retrieval (E) sessions in mice expressing EGFP or hM3Dq in SST+ interneurons. two-way ANOVA (Phase × AAV) revealed a significant main effect of AAV (F(1,58) = 7.40, p = 0.0086), indicating that the chemogenetic activation of SST+ interneurons influences DI performance independent of behavioral phase. Neither the main effect of Phase (F(2,58) = 1.69, p = 0.1936) nor the Phase × AAV interaction reached significance (F(2,58) = 2.41, p = 0.0985), though the interaction showed a trend. Closer inspection of the data showed the largest effects of SST+ interneuron activation on OLM encoding ( p = 0.0047, Tukey’s test) and retrieval ( p = 0.046, Tukey’s test), but had no effect on consolidation ( p = 0.8804). (F) Vehicle administration did not affect OLM encoding ( p = 0.755, n = 8–9 animals/group). For all panels, # p < 0.1, ∗ p < 0.05. Data are presented as mean ± SEM.
Dreadd Agonist Compound 21, supplied by Tocris, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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dreadd agonist compound 21 - by Bioz Stars, 2026-04
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compound 21  (Tocris)
95
Tocris compound 21
Effects of SST+ interneuron activation across different stages of spatial memory processing (A) Male and female SST-CRE mice ( n = 9 animals/group for encoding and consolidation; n = 14–15 animals/group for retrieval) are transduced to express Cre-dependent hM3Dq-mCitrine or EGFP (control) in DG. Beginning four weeks after viral transduction, SST+ interneurons were activated separately either during OLM encoding, consolidation, or retrieval, with two weeks of rest between OLM trials, which ended with a final trial in which vehicle is administered prior to encoding. (B) Timing of <t>compound</t> <t>21</t> (C21) administration relative to OLM encoding, consolidation, or retrieval. Mouse interaction with the moved vs. unmoved object is quantified to generate the OLM discrimination index (DI). (C–E) Discrimination index scores for encoding (C), consolidation (D), and retrieval (E) sessions in mice expressing EGFP or hM3Dq in SST+ interneurons. two-way ANOVA (Phase × AAV) revealed a significant main effect of AAV (F(1,58) = 7.40, p = 0.0086), indicating that the chemogenetic activation of SST+ interneurons influences DI performance independent of behavioral phase. Neither the main effect of Phase (F(2,58) = 1.69, p = 0.1936) nor the Phase × AAV interaction reached significance (F(2,58) = 2.41, p = 0.0985), though the interaction showed a trend. Closer inspection of the data showed the largest effects of SST+ interneuron activation on OLM encoding ( p = 0.0047, Tukey’s test) and retrieval ( p = 0.046, Tukey’s test), but had no effect on consolidation ( p = 0.8804). (F) Vehicle administration did not affect OLM encoding ( p = 0.755, n = 8–9 animals/group). For all panels, # p < 0.1, ∗ p < 0.05. Data are presented as mean ± SEM.
Compound 21, supplied by Tocris, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/compound 21/product/Tocris
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compound 21 - by Bioz Stars, 2026-04
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dreadd agonist compound 21  (Hello Bio Inc)
90
Hello Bio Inc dreadd agonist compound 21
Effects of SST+ interneuron activation across different stages of spatial memory processing (A) Male and female SST-CRE mice ( n = 9 animals/group for encoding and consolidation; n = 14–15 animals/group for retrieval) are transduced to express Cre-dependent hM3Dq-mCitrine or EGFP (control) in DG. Beginning four weeks after viral transduction, SST+ interneurons were activated separately either during OLM encoding, consolidation, or retrieval, with two weeks of rest between OLM trials, which ended with a final trial in which vehicle is administered prior to encoding. (B) Timing of <t>compound</t> <t>21</t> (C21) administration relative to OLM encoding, consolidation, or retrieval. Mouse interaction with the moved vs. unmoved object is quantified to generate the OLM discrimination index (DI). (C–E) Discrimination index scores for encoding (C), consolidation (D), and retrieval (E) sessions in mice expressing EGFP or hM3Dq in SST+ interneurons. two-way ANOVA (Phase × AAV) revealed a significant main effect of AAV (F(1,58) = 7.40, p = 0.0086), indicating that the chemogenetic activation of SST+ interneurons influences DI performance independent of behavioral phase. Neither the main effect of Phase (F(2,58) = 1.69, p = 0.1936) nor the Phase × AAV interaction reached significance (F(2,58) = 2.41, p = 0.0985), though the interaction showed a trend. Closer inspection of the data showed the largest effects of SST+ interneuron activation on OLM encoding ( p = 0.0047, Tukey’s test) and retrieval ( p = 0.046, Tukey’s test), but had no effect on consolidation ( p = 0.8804). (F) Vehicle administration did not affect OLM encoding ( p = 0.755, n = 8–9 animals/group). For all panels, # p < 0.1, ∗ p < 0.05. Data are presented as mean ± SEM.
Dreadd Agonist Compound 21, supplied by Hello Bio Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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compounds 9–14, 16, 19–21, and gc-373  (Molecular Dynamics Inc)
90
Molecular Dynamics Inc compounds 9–14, 16, 19–21, and gc-373
Effects of SST+ interneuron activation across different stages of spatial memory processing (A) Male and female SST-CRE mice ( n = 9 animals/group for encoding and consolidation; n = 14–15 animals/group for retrieval) are transduced to express Cre-dependent hM3Dq-mCitrine or EGFP (control) in DG. Beginning four weeks after viral transduction, SST+ interneurons were activated separately either during OLM encoding, consolidation, or retrieval, with two weeks of rest between OLM trials, which ended with a final trial in which vehicle is administered prior to encoding. (B) Timing of <t>compound</t> <t>21</t> (C21) administration relative to OLM encoding, consolidation, or retrieval. Mouse interaction with the moved vs. unmoved object is quantified to generate the OLM discrimination index (DI). (C–E) Discrimination index scores for encoding (C), consolidation (D), and retrieval (E) sessions in mice expressing EGFP or hM3Dq in SST+ interneurons. two-way ANOVA (Phase × AAV) revealed a significant main effect of AAV (F(1,58) = 7.40, p = 0.0086), indicating that the chemogenetic activation of SST+ interneurons influences DI performance independent of behavioral phase. Neither the main effect of Phase (F(2,58) = 1.69, p = 0.1936) nor the Phase × AAV interaction reached significance (F(2,58) = 2.41, p = 0.0985), though the interaction showed a trend. Closer inspection of the data showed the largest effects of SST+ interneuron activation on OLM encoding ( p = 0.0047, Tukey’s test) and retrieval ( p = 0.046, Tukey’s test), but had no effect on consolidation ( p = 0.8804). (F) Vehicle administration did not affect OLM encoding ( p = 0.755, n = 8–9 animals/group). For all panels, # p < 0.1, ∗ p < 0.05. Data are presented as mean ± SEM.
Compounds 9–14, 16, 19–21, And Gc 373, supplied by Molecular Dynamics Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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compound 21 c21  (Hello Bio Inc)
90
Hello Bio Inc compound 21 c21
Effects of SST+ interneuron activation across different stages of spatial memory processing (A) Male and female SST-CRE mice ( n = 9 animals/group for encoding and consolidation; n = 14–15 animals/group for retrieval) are transduced to express Cre-dependent hM3Dq-mCitrine or EGFP (control) in DG. Beginning four weeks after viral transduction, SST+ interneurons were activated separately either during OLM encoding, consolidation, or retrieval, with two weeks of rest between OLM trials, which ended with a final trial in which vehicle is administered prior to encoding. (B) Timing of <t>compound</t> <t>21</t> (C21) administration relative to OLM encoding, consolidation, or retrieval. Mouse interaction with the moved vs. unmoved object is quantified to generate the OLM discrimination index (DI). (C–E) Discrimination index scores for encoding (C), consolidation (D), and retrieval (E) sessions in mice expressing EGFP or hM3Dq in SST+ interneurons. two-way ANOVA (Phase × AAV) revealed a significant main effect of AAV (F(1,58) = 7.40, p = 0.0086), indicating that the chemogenetic activation of SST+ interneurons influences DI performance independent of behavioral phase. Neither the main effect of Phase (F(2,58) = 1.69, p = 0.1936) nor the Phase × AAV interaction reached significance (F(2,58) = 2.41, p = 0.0985), though the interaction showed a trend. Closer inspection of the data showed the largest effects of SST+ interneuron activation on OLM encoding ( p = 0.0047, Tukey’s test) and retrieval ( p = 0.046, Tukey’s test), but had no effect on consolidation ( p = 0.8804). (F) Vehicle administration did not affect OLM encoding ( p = 0.755, n = 8–9 animals/group). For all panels, # p < 0.1, ∗ p < 0.05. Data are presented as mean ± SEM.
Compound 21 C21, supplied by Hello Bio Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Effects of SST+ interneuron activation across different stages of spatial memory processing (A) Male and female SST-CRE mice ( n = 9 animals/group for encoding and consolidation; n = 14–15 animals/group for retrieval) are transduced to express Cre-dependent hM3Dq-mCitrine or EGFP (control) in DG. Beginning four weeks after viral transduction, SST+ interneurons were activated separately either during OLM encoding, consolidation, or retrieval, with two weeks of rest between OLM trials, which ended with a final trial in which vehicle is administered prior to encoding. (B) Timing of compound 21 (C21) administration relative to OLM encoding, consolidation, or retrieval. Mouse interaction with the moved vs. unmoved object is quantified to generate the OLM discrimination index (DI). (C–E) Discrimination index scores for encoding (C), consolidation (D), and retrieval (E) sessions in mice expressing EGFP or hM3Dq in SST+ interneurons. two-way ANOVA (Phase × AAV) revealed a significant main effect of AAV (F(1,58) = 7.40, p = 0.0086), indicating that the chemogenetic activation of SST+ interneurons influences DI performance independent of behavioral phase. Neither the main effect of Phase (F(2,58) = 1.69, p = 0.1936) nor the Phase × AAV interaction reached significance (F(2,58) = 2.41, p = 0.0985), though the interaction showed a trend. Closer inspection of the data showed the largest effects of SST+ interneuron activation on OLM encoding ( p = 0.0047, Tukey’s test) and retrieval ( p = 0.046, Tukey’s test), but had no effect on consolidation ( p = 0.8804). (F) Vehicle administration did not affect OLM encoding ( p = 0.755, n = 8–9 animals/group). For all panels, # p < 0.1, ∗ p < 0.05. Data are presented as mean ± SEM.

Journal: iScience

Article Title: Dentate gyrus network regulation by somatostatin- and parvalbumin-expressing interneurons differentially impacts spatial memory processing

doi: 10.1016/j.isci.2026.115067

Figure Lengend Snippet: Effects of SST+ interneuron activation across different stages of spatial memory processing (A) Male and female SST-CRE mice ( n = 9 animals/group for encoding and consolidation; n = 14–15 animals/group for retrieval) are transduced to express Cre-dependent hM3Dq-mCitrine or EGFP (control) in DG. Beginning four weeks after viral transduction, SST+ interneurons were activated separately either during OLM encoding, consolidation, or retrieval, with two weeks of rest between OLM trials, which ended with a final trial in which vehicle is administered prior to encoding. (B) Timing of compound 21 (C21) administration relative to OLM encoding, consolidation, or retrieval. Mouse interaction with the moved vs. unmoved object is quantified to generate the OLM discrimination index (DI). (C–E) Discrimination index scores for encoding (C), consolidation (D), and retrieval (E) sessions in mice expressing EGFP or hM3Dq in SST+ interneurons. two-way ANOVA (Phase × AAV) revealed a significant main effect of AAV (F(1,58) = 7.40, p = 0.0086), indicating that the chemogenetic activation of SST+ interneurons influences DI performance independent of behavioral phase. Neither the main effect of Phase (F(2,58) = 1.69, p = 0.1936) nor the Phase × AAV interaction reached significance (F(2,58) = 2.41, p = 0.0985), though the interaction showed a trend. Closer inspection of the data showed the largest effects of SST+ interneuron activation on OLM encoding ( p = 0.0047, Tukey’s test) and retrieval ( p = 0.046, Tukey’s test), but had no effect on consolidation ( p = 0.8804). (F) Vehicle administration did not affect OLM encoding ( p = 0.755, n = 8–9 animals/group). For all panels, # p < 0.1, ∗ p < 0.05. Data are presented as mean ± SEM.

Article Snippet: DREADD agonist compound 21 , Tocris , 5548.

Techniques: Activation Assay, Control, Transduction, Expressing