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circ axl  (Proteostasis Therapeutics)
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Proteostasis Therapeutics circ axl
The primary roles of circRNAs. ( A ) circRNAs may function as sponges for miRNAs, as shown by <t>circ-AXL,</t> which has target sites for miR-328. ( B ) circRNAs may engage with certain mRNAs and modulate their stability and/or translation. An instance is the circ-Bptf interaction with p62 mRNA. ( C ) CircRNAs may be translated to yield tiny peptides, as shown by the translation of circCDYL2 into the Cdyl2-60aa peptide, which is around 7 kDa. ( D ) CircRNAs with motifs that can bind to RNA-binding proteins have the ability to function as decoys or sponges for these proteins, therefore regulating their activity. CircRNAs with patterns that promote the interaction between an enzyme and its substrate may function as scaffolds, facilitating the co-localization of the two entities and enhancing reaction kinetics. CircRNAs may engage with gene promoters, recruit TET1 demethylase, and induce substantial demethylation of CpG islands in the DNA. CircRNAs may bind to U1 snRNP and then interact with the RNA polymerase II transcription complex, hence increasing protein expression. snRNA refers to small nuclear RNA, whereas snRNP denotes small nuclear ribonucleoprotein.
Circ Axl, supplied by Proteostasis Therapeutics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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The primary roles of circRNAs. ( A ) circRNAs may function as sponges for miRNAs, as shown by circ-AXL, which has target sites for miR-328. ( B ) circRNAs may engage with certain mRNAs and modulate their stability and/or translation. An instance is the circ-Bptf interaction with p62 mRNA. ( C ) CircRNAs may be translated to yield tiny peptides, as shown by the translation of circCDYL2 into the Cdyl2-60aa peptide, which is around 7 kDa. ( D ) CircRNAs with motifs that can bind to RNA-binding proteins have the ability to function as decoys or sponges for these proteins, therefore regulating their activity. CircRNAs with patterns that promote the interaction between an enzyme and its substrate may function as scaffolds, facilitating the co-localization of the two entities and enhancing reaction kinetics. CircRNAs may engage with gene promoters, recruit TET1 demethylase, and induce substantial demethylation of CpG islands in the DNA. CircRNAs may bind to U1 snRNP and then interact with the RNA polymerase II transcription complex, hence increasing protein expression. snRNA refers to small nuclear RNA, whereas snRNP denotes small nuclear ribonucleoprotein.

Journal: Metabolism Open

Article Title: Non-coding RNAs in neurodegeneration: an axis-based, evidence-tiered mechanistic synthesis

doi: 10.1016/j.metop.2026.100458

Figure Lengend Snippet: The primary roles of circRNAs. ( A ) circRNAs may function as sponges for miRNAs, as shown by circ-AXL, which has target sites for miR-328. ( B ) circRNAs may engage with certain mRNAs and modulate their stability and/or translation. An instance is the circ-Bptf interaction with p62 mRNA. ( C ) CircRNAs may be translated to yield tiny peptides, as shown by the translation of circCDYL2 into the Cdyl2-60aa peptide, which is around 7 kDa. ( D ) CircRNAs with motifs that can bind to RNA-binding proteins have the ability to function as decoys or sponges for these proteins, therefore regulating their activity. CircRNAs with patterns that promote the interaction between an enzyme and its substrate may function as scaffolds, facilitating the co-localization of the two entities and enhancing reaction kinetics. CircRNAs may engage with gene promoters, recruit TET1 demethylase, and induce substantial demethylation of CpG islands in the DNA. CircRNAs may bind to U1 snRNP and then interact with the RNA polymerase II transcription complex, hence increasing protein expression. snRNA refers to small nuclear RNA, whereas snRNP denotes small nuclear ribonucleoprotein.

Article Snippet: Proteostasis/Protein aggregation , AD , circRNA , circ-AXL, circ-LPAR1 , Modulate inflammatory & amyloid pathways via miRNA axes , Mouse/Cell , Expression + perturbation , Tier 2 , Therapeutic target preclinical , [ , ] .

Techniques: RNA Binding Assay, Activity Assay, Expressing