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Evaluation of titanium microscrews after implantation into rat tibia. Microscrews with 25 μm (yellow) (A) or 50 μm (green) (B) electrospun polycaprolactone–cholecalciferol coatings were implanted into rat tibia. Longitudinal (i) and transverse (ii) micro-computed tomography views, showing segmented peri-microscrew tissue around screws. 3D reconstruction of peri-microscrew tissue (iii) and corresponding tissue thickness map (iv) viewed from above. The color scale indicates local tissue thickness (mm). Osseointegration was evaluated within a cylindrical volume of interest of 1.6 mm in diameter and 1.8 mm in height.

Journal: In Vivo

Article Title: Refined Surgical Protocol for the Insertion of Bioactive-coated Titanium Microscrews in the Rat Tibia

doi: 10.21873/invivo.14181

Figure Lengend Snippet: Evaluation of titanium microscrews after implantation into rat tibia. Microscrews with 25 μm (yellow) (A) or 50 μm (green) (B) electrospun polycaprolactone–cholecalciferol coatings were implanted into rat tibia. Longitudinal (i) and transverse (ii) micro-computed tomography views, showing segmented peri-microscrew tissue around screws. 3D reconstruction of peri-microscrew tissue (iii) and corresponding tissue thickness map (iv) viewed from above. The color scale indicates local tissue thickness (mm). Osseointegration was evaluated within a cylindrical volume of interest of 1.6 mm in diameter and 1.8 mm in height.

Article Snippet: This study aimed to develop and validate a refined surgical protocol for inserting such polycaprolactone-cholecalciferol-coated titanium microscrews into the proximal tibia of Sprague-Dawley rats, ensuring primary stability and preserving the integrity of the nanofibrous coating.

Techniques: Micro-CT