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Journal: Cancer discovery
Article Title: p38MAPK plays a crucial role in stromal mediated tumorigenesis
doi: 10.1158/2159-8290.CD-13-0743
Figure Lengend Snippet: (A) Western blot analysis demonstrating that SB203580 treatment inhibits p38MAPK activity. As expected, SB203580 treatment significantly impacts phosphorylation of p38MAPK’s direct downstream target, Hsp27. Total Hsp27 was used as loading control.
Article Snippet: Oral dosage of
Techniques: Western Blot, Activity Assay
Journal: Cancer discovery
Article Title: p38MAPK plays a crucial role in stromal mediated tumorigenesis
doi: 10.1158/2159-8290.CD-13-0743
Figure Lengend Snippet: (A) RNA-seq analysis was performed on young fibroblasts, senescent fibroblasts, and senescent fibroblasts treated with SB203580. RNA-seq results were analyzed to determine the number of factors upregulated in response to senescence (SASP factors) and the number of p38MAPK-dependent factors. These results were also analyzed for overlap with the expression profiles of breast cancer (BC)-associated stroma.
Article Snippet: Oral dosage of
Techniques: RNA Sequencing Assay, Expressing
Journal: Cancer discovery
Article Title: p38MAPK plays a crucial role in stromal mediated tumorigenesis
doi: 10.1158/2159-8290.CD-13-0743
Figure Lengend Snippet: (A) Western blot analysis demonstrating that SB203580 treatment inhibits p38MAPK activity. As expected, SB203580 treatment significantly impacts phosphorylation of p38MAPK’s direct downstream target, Hsp27. Total Hsp27 was used as loading control.
Article Snippet: We obtained a
Techniques: Western Blot, Activity Assay, Phospho-proteomics, Control
Journal: Cancer discovery
Article Title: p38MAPK plays a crucial role in stromal mediated tumorigenesis
doi: 10.1158/2159-8290.CD-13-0743
Figure Lengend Snippet: (A) RNA-seq analysis was performed on young fibroblasts, senescent fibroblasts, and senescent fibroblasts treated with SB203580. RNA-seq results were analyzed to determine the number of factors upregulated in response to senescence (SASP factors) and the number of p38MAPK-dependent factors. These results were also analyzed for overlap with the expression profiles of breast cancer (BC)-associated stroma.
Article Snippet: We obtained a
Techniques: RNA Sequencing, Expressing
Journal: Cancer discovery
Article Title: p38MAPK plays a crucial role in stromal mediated tumorigenesis
doi: 10.1158/2159-8290.CD-13-0743
Figure Lengend Snippet: (A) Western blot analysis demonstrating that SB203580 treatment inhibits p38MAPK activity. As expected, SB203580 treatment significantly impacts phosphorylation of p38MAPK’s direct downstream target, Hsp27. Total Hsp27 was used as loading control.
Article Snippet: Oral dosage of p38MAPK inhibitor The
Techniques: Western Blot, Activity Assay, Phospho-proteomics, Control
Journal: Cancer discovery
Article Title: p38MAPK plays a crucial role in stromal mediated tumorigenesis
doi: 10.1158/2159-8290.CD-13-0743
Figure Lengend Snippet: (A) RNA-seq analysis was performed on young fibroblasts, senescent fibroblasts, and senescent fibroblasts treated with SB203580. RNA-seq results were analyzed to determine the number of factors upregulated in response to senescence (SASP factors) and the number of p38MAPK-dependent factors. These results were also analyzed for overlap with the expression profiles of breast cancer (BC)-associated stroma.
Article Snippet: Oral dosage of p38MAPK inhibitor The
Techniques: RNA Sequencing, Expressing