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a , b Follicular neoplasm mostly composed of clusters of follicular cells, medium-sized groups, with a microfollicular architecture (liquid-based cytology, Pap stain × 20 and × 40). c Positivity for HBME-1 in one of the clusters; d positivity for Galectin-3; e Positivity for <t>VE1-BRAF</t> ( a and b × 40)
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braf ve1  (Galectin Therapeutics)
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a , b Follicular neoplasm mostly composed of clusters of follicular cells, medium-sized groups, with a microfollicular architecture (liquid-based cytology, Pap stain × 20 and × 40). c Positivity for HBME-1 in one of the clusters; d positivity for Galectin-3; e Positivity for <t>VE1-BRAF</t> ( a and b × 40)
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ve1 braf  (Galectin Therapeutics)
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a , b Follicular neoplasm mostly composed of clusters of follicular cells, medium-sized groups, with a microfollicular architecture (liquid-based cytology, Pap stain × 20 and × 40). c Positivity for HBME-1 in one of the clusters; d positivity for Galectin-3; e Positivity <t>for</t> <t>VE1-BRAF</t> ( a and b × 40)
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braf p.v600e-directed antibody clone ve1  (Eurobio)
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a , b Follicular neoplasm mostly composed of clusters of follicular cells, medium-sized groups, with a microfollicular architecture (liquid-based cytology, Pap stain × 20 and × 40). c Positivity for HBME-1 in one of the clusters; d positivity for Galectin-3; e Positivity <t>for</t> <t>VE1-BRAF</t> ( a and b × 40)
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a , b Follicular neoplasm mostly composed of clusters of follicular cells, medium-sized groups, with a microfollicular architecture (liquid-based cytology, Pap stain × 20 and × 40). c Positivity for HBME-1 in one of the clusters; d positivity for Galectin-3; e Positivity <t>for</t> <t>VE1-BRAF</t> ( a and b × 40)
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a , b Follicular neoplasm mostly composed of clusters of follicular cells, medium-sized groups, with a microfollicular architecture (liquid-based cytology, Pap stain × 20 and × 40). c Positivity for HBME-1 in one of the clusters; d positivity for Galectin-3; e Positivity <t>for</t> <t>VE1-BRAF</t> ( a and b × 40)
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braf abcam clone ve1 reference ab228461 dilution 1 200  (Danaher Inc)
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a , b Follicular neoplasm mostly composed of clusters of follicular cells, medium-sized groups, with a microfollicular architecture (liquid-based cytology, Pap stain × 20 and × 40). c Positivity for HBME-1 in one of the clusters; d positivity for Galectin-3; e Positivity <t>for</t> <t>VE1-BRAF</t> ( a and b × 40)
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a , b Follicular neoplasm mostly composed of clusters of follicular cells, medium-sized groups, with a microfollicular architecture (liquid-based cytology, Pap stain × 20 and × 40). c Positivity for HBME-1 in one of the clusters; d positivity for Galectin-3; e Positivity for VE1-BRAF ( a and b × 40)

Journal: Virchows Archiv

Article Title: Histopathologic and ancillary findings of subcentimeter thyroid nodules diagnosed as follicular neoplasms: a retrospective institutional study

doi: 10.1007/s00428-025-04308-x

Figure Lengend Snippet: a , b Follicular neoplasm mostly composed of clusters of follicular cells, medium-sized groups, with a microfollicular architecture (liquid-based cytology, Pap stain × 20 and × 40). c Positivity for HBME-1 in one of the clusters; d positivity for Galectin-3; e Positivity for VE1-BRAF ( a and b × 40)

Article Snippet: ICC staining of slides was carried out with the avidin–biotin peroxidase complex using a selection of specific antibodies (in details HBME-1, Galectin-3, BRAF VE1).

Techniques: Papanicolaou Stain

a , b Follicular neoplasm mostly composed of clusters of follicular cells, medium-sized groups, with a microfollicular architecture (liquid-based cytology, Pap stain × 20 and × 40). c Positivity for HBME-1 in one of the clusters; d positivity for Galectin-3; e Positivity for VE1-BRAF ( a and b × 40)

Journal: Virchows Archiv

Article Title: Histopathologic and ancillary findings of subcentimeter thyroid nodules diagnosed as follicular neoplasms: a retrospective institutional study

doi: 10.1007/s00428-025-04308-x

Figure Lengend Snippet: a , b Follicular neoplasm mostly composed of clusters of follicular cells, medium-sized groups, with a microfollicular architecture (liquid-based cytology, Pap stain × 20 and × 40). c Positivity for HBME-1 in one of the clusters; d positivity for Galectin-3; e Positivity for VE1-BRAF ( a and b × 40)

Article Snippet: By comparison, the subset of cases within the AUS category showed 100% negativity for BRAF VE1, while five cases had weak positivity for HBME-1 and three cases weak positivity for Galectin-3.

Techniques: Papanicolaou Stain

a , b Follicular neoplasm mostly composed of clusters of follicular cells, medium-sized groups, with a microfollicular architecture (liquid-based cytology, Pap stain × 20 and × 40). c Positivity for HBME-1 in one of the clusters; d positivity for Galectin-3; e Positivity for VE1-BRAF ( a and b × 40)

Journal: Virchows Archiv

Article Title: Histopathologic and ancillary findings of subcentimeter thyroid nodules diagnosed as follicular neoplasms: a retrospective institutional study

doi: 10.1007/s00428-025-04308-x

Figure Lengend Snippet: a , b Follicular neoplasm mostly composed of clusters of follicular cells, medium-sized groups, with a microfollicular architecture (liquid-based cytology, Pap stain × 20 and × 40). c Positivity for HBME-1 in one of the clusters; d positivity for Galectin-3; e Positivity for VE1-BRAF ( a and b × 40)

Article Snippet: Among the histological malignant cases, only three (6.1%) cases had a moderate positivity for VE1-BRAF, with eight (16.3%) cases showing a concordant positive HMBE1 and Galectin-3 panel.

Techniques: Papanicolaou Stain