Journal: bioRxiv

Article Title: Mesohabenular glutamatergic regulation of the consequences of uncontrollable stress

doi: 10.64898/2026.07.21.739922

Figure Lengend Snippet: A . Experimental setup. B . Example GFP expression in LHb. Scale Bar is 500 µm. Colored lines represent localization of fiber optic. Numbers refer to mm from bregma. C . Quarter wheel turns satisfying criterion to terminate tailshock over ten blocks of ten trials. Significance is compared to first block of trials. D . Time with social and nonsocial stimuli in male mice across groups. E . Social scores across groups in male mice. F . Time spent freezing in male mice across groups. G . Latency to enter the light side of the light dark box in female mice. H . Time spent in light side of the light dark box in female mice. ES – escapable stress; GFP – green fluorescent protein inescapable stress control group; G – H VTA glutamate → LHb halorhodopsin; GG – H VTA glutamate-GABA → LHb halorhodopsin. p < 0.05, ** p < 0.01, ns not significant.

Article Snippet: Twenty-four hours after tailshock, IS or NS female mice were placed in the center of the dark compartment of the light/dark box (Stoelting).

Techniques: Expressing, Blocking Assay, Control

Journal: Alzheimer's & Dementia

Article Title: Amyloid exacerbates tau and alpha‐synuclein pathologies, behavioral impairments, and neuroinflammation in a mixed dementia model

doi: 10.1002/alz.71639

Figure Lengend Snippet: Co‐induced asyn and tau pathologies exacerbate amyloid‐associated hyperactivity and anxiety‐like behaviors. (A–C) Open‐field assay behaviors were measured in post‐plaque treated mice at baseline (6 months of age), 3 mpi (9 months of age), and 6 mpi (12 months of age). Metrics for (A) total distance traveled, (B) center:total distance traveled ratio, and (C) time spent rearing were automatically recorded during each test. Points show group means with error bars (± SEM). Statistics: two‐way ANOVA (factors: mouseline, treatment) with interaction and Fisher's least significant difference post hoc test for multiple comparisons (* p ≤ 0.05, ** p ≤ 0.01, **** p ≤ 0.0001). Asterisks denote significant relative EGFP at a given time point and are colored by group for overlapping data points. N = 8 to 17 mice/mouseline/treatment/time point, roughly equal male:female.

Article Snippet: Mice were placed in the center of an open‐field space (40 × 40 × 30 cm, W × L × H; Stoelting, Catalog No.: 62000) with opaque walls and allowed to freely explore for 15 min. To detect rearing behavior, infrared photobeam sensors external to the apparatus were elevated 3 cm (apparatus base to bottom of sensor).

Techniques:

Journal: Alzheimer's & Dementia

Article Title: Amyloid exacerbates tau and alpha‐synuclein pathologies, behavioral impairments, and neuroinflammation in a mixed dementia model

doi: 10.1002/alz.71639

Figure Lengend Snippet: Pre‐plaque alpha‐synuclein and tau pathologies potentiate emerging APP behavioral phenotypes. (A–C) Open‐field assay behaviors were measured in pre‐plaque treated mice at baseline (3 months of age), 3 mpi (6 months of age), and 6 mpi (9 months of age). Metrics for (A) total distance traveled, (B) center:total distance traveled ratio, and (C) time spent rearing were automatically recorded during each test. Points show group means with error bars (± SEM). Statistics: two‐way ANOVA (factors: mouseline, treatment) with interaction and Fisher's least significant difference post hoc test for multiple comparisons (* p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p ≤ 0.0001). Asterisks denote significant relative EGFP at a given time point and are colored by group for overlapping data points. N = 22 to 27 mice/mouseline/treatment/time point, roughly equal male:female.

Article Snippet: Mice were placed in the center of an open‐field space (40 × 40 × 30 cm, W × L × H; Stoelting, Catalog No.: 62000) with opaque walls and allowed to freely explore for 15 min. To detect rearing behavior, infrared photobeam sensors external to the apparatus were elevated 3 cm (apparatus base to bottom of sensor).

Techniques: